Rutgers, The State University Of New Jersey

This study tests whether adding the drug tislelizumab after standard local treatments (like radiation) can help control advanced liver cancer that cannot be removed by surgery. The goal is to prevent the cancer from growing or spreading. About 35 adults with liver cancer will tak…

This 12-month study tests whether a nurse-led smartphone app can help people with type 2 diabetes who use insulin and are on Medicaid better manage their blood sugar. Participants will use the app to track glucose, get education, and receive phone support from nurses. The goal is…

This study is for people with a type of bile duct cancer that cannot be removed by surgery and has not spread. Participants will receive chemotherapy first, and if the cancer stays stable or shrinks for at least 6 months, they may get a liver transplant. The goal is to see if thi…

This study is testing a smartphone app designed to help women in Nepal manage gestational diabetes during pregnancy. The app provides culturally tailored support for self-care, such as tracking blood sugar and lifestyle habits. Researchers will compare outcomes like blood sugar l…

This study tests two counseling approaches—Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement—to help people on methadone treatment reduce tobacco smoking and other drug use. Researchers will enroll 420 adults who are on methadone and smoke cigarettes. The go…

This study tests a combination of chemotherapy drugs (sFOLFOXIRI) in 38 people with advanced stomach, esophagus, or gastroesophageal junction cancer that cannot be removed by surgery. The goal is to see if this treatment can shrink tumors and help people live longer. Participants…

This study tests whether adding statins can prevent heart problems caused by HER2-targeted therapy in people with early-stage breast cancer. About 60 women will take statins alongside their cancer treatment to see if it reduces treatment delays or early stops. The goal is to keep…

This study looks at whether adjusting chemotherapy doses based on a patient's DPYD gene test can lower the risk of severe side effects. About 100 adults with certain cancers (like colorectal or breast) will get either a standard or a gene-guided lower dose. The goal is to see if …

This study is testing whether tirzepatide, a drug used for weight loss, can help people with early-stage hormone-positive breast cancer lose at least 5% of their body weight during their regular cancer treatment. About 40 participants will take the drug and be monitored for safet…

This study compares once-daily long-acting insulin to the standard regimen of long-acting plus meal-time insulin in pregnant women with diabetes. The goal is to see if the simpler one-shot approach controls blood sugar just as well and doesn't increase baby complications. About 1…

This study is for people with advanced lung or head & neck cancers. It tests a new way of giving chemotherapy and immunotherapy (pembrolizumab) by alternating cycles. The goal is to see if this schedule helps patients complete more treatment cycles and improves cancer control. Ab…

This study tests a new combination of chemotherapy drugs (TAS-102, oxaliplatin, irinotecan) plus bevacizumab for people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this approach can control the disease and slow its gro…

This study tests whether giving a higher-than-standard dose of buprenorphine (32 mg instead of 12 mg) is safe and helps more people with opioid addiction start comprehensive treatment within 7 days. About 140 adults with moderate to severe opioid use disorder who test positive fo…

This study tests a new way to personalize treatment for people with HER2-positive early-stage breast cancer. A special test (HARPS) analyzes the tumor to see if it will respond to certain drugs. Based on the results, patients receive a tailored treatment plan before surgery. The …

This study tests whether giving infants their own preserved stool after antibiotic treatment can quickly restore healthy gut bacteria. Researchers will collect a stool sample before antibiotics, then mix it into milk or formula and feed it back to the baby. The goal is to see if …

This study tests a two-drug treatment (gemcitabine and Jelmyto) for a type of high-risk urinary tract cancer. The goal is to destroy the tumor while keeping the kidney intact, avoiding the standard surgery that removes the kidney. About 28 adults with non-invasive, high-grade can…

This study looks at whether different types of exercise can improve brain health and reduce the risk of Alzheimer's disease in older African Americans. Researchers will compare a cardio-dance fitness program to a strength, flexibility, and balance program over six months. Partici…

This study is testing a mobile health app designed to help Hispanic adults protect their skin from the sun and check for skin cancer. Researchers will enroll 114 Hispanic adults who are at risk for skin cancer but do not currently practice good sun protection. Half will get the a…

This study tests whether sulfasalazine, a drug used for arthritis, can prevent preterm birth in women who have had one before. About 50 pregnant women will take the drug or be in a control group, and researchers will measure a stress hormone called CRH. The goal is to see if the …

This study tests whether melatonin, a natural sleep hormone, can prevent kidney injury caused by the antibiotic vancomycin. Researchers will give melatonin to 300 hospitalized adults aged 18-75 who are starting vancomycin therapy. The goal is to see if melatonin reduces the risk …

This study compares two methods for controlling pain after outpatient orthopedic surgeries like ACL repair or rotator cuff surgery: a continuous pain pump versus a single nerve block given before surgery. About 80 adults will be randomly assigned to one of the two groups. The goa…

This study tests a smarter way to give radiation to people with lung cancer. Normally, the radiation plan is made before treatment starts, but tumors can shrink during treatment, which may expose healthy tissue to unnecessary radiation. In this study, the radiation plan is update…

This study tests whether a fast-paced form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help adults in a substance use treatment program. About 168 participants will either receive M-PE or their usual trauma care. Researchers will track changes in PTSD symptoms, …

This study looks at whether giving a numbing injection to the throat during vocal cord surgery can help reduce pain, coughing, and improve voice recovery afterward. About 28 adults with benign vocal cord lesions will be randomly assigned to receive either the numbing medicine or …

This study tests whether a gel called RADA16 can improve recovery for children aged 3 to 17 after tonsil removal. About 134 children will either get the gel or standard care. Researchers will track pain and bleeding for 30 days after surgery.

This study tests a special gel (RADA-16) applied during tonsil removal to see if it reduces bleeding and pain after surgery. About 134 adults having their tonsils out will either get the gel or standard care. Participants will track their symptoms through online surveys every oth…

This study looks at whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can help older African Americans sleep better. About 20 people aged 60 and older with long-term sleep problems will take part. They will attend 8 weekly sleep coaching sess…

This study looks at whether Latin dancing can improve sleep quality in Hispanic cancer survivors. About 40 adults who have finished their main cancer treatment will either take dance classes or continue their usual routine. The goal is to see if dancing is a fun and helpful way t…

This study looks at whether a special numbing injection, called the Twin Block, can reduce jaw muscle pain after wisdom tooth removal. About 48 healthy adults who have pain the day after surgery will receive either the injection or a placebo. The goal is to see if this simple, sa…

This study is for adults with cancer that has spread to bones or other areas, causing pain. Researchers want to see if giving a higher dose of radiation (40-50 Gy over 10 sessions) can provide more complete pain relief within a month and make that relief last longer. About 124 pe…

This study tests whether a new wound dressing called Pelashield PainGuard helps people heal better after surgery for hidradenitis suppurativa (HS) compared to the current standard dressing, Restrata. Pelashield contains silver to fight bacteria and lidocaine to reduce pain. Ten a…

This study tests whether using a virtual reality headset can help young adults aged 18-25 with ADHD concentrate better while studying or doing homework. Some participants will use the VR headset alone, while others will also receive real-time feedback on their focus levels. The g…

This study looks at whether a special therapy method can stop problem behaviors like aggression or self-injury from returning in children after they've been successfully treated. The researchers will work with 30 children aged 3 to 17 who have frequent problem behaviors. They wil…

This study tests whether a special numbing injection called a Temporo-masseteric Nerve Block can reduce pain after wisdom tooth removal. About 20 adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels and any p…

This study is developing a smartphone app that uses mindfulness techniques to help cancer survivors quit smoking. About 50 adults who have been diagnosed with cancer and smoke at least one cigarette a day will test the app. Researchers will measure how easy the app is to use and …

This study tests a smartphone-based sleep program (Sleepio) for teens ages 14-18 who have insomnia and were recently hospitalized for suicidal thoughts or behavior. The goal is to see if improving sleep can lower suicide risk. Participants will either receive the sleep program pl…

This study tests whether a mindfulness program delivered through a mobile app can help reduce anxiety in older adults (60+) with serious illnesses like cancer or heart disease, and their caregivers. About 162 participants will use the app at home. The goal is to find a simple, ac…

This study is testing whether an AI-powered conversational agent can deliver a proven therapy (Dialectical Behavior Therapy) to help older adults with HIV manage suicidal thoughts and emotions. About 50 people aged 50 and older who are at risk for suicide will try the program. Th…

This study looks at whether eating peanuts every day can improve bone health, metabolic health, and weight loss in overweight adults aged 50-75. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free snack for 24 weeks while following a weight los…

This study aims to find out how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even if they don't have cancer. Participants fill out online surveys and mail in a saliva sample. As a thank-you, you may get free information about your genetic ance…

This study looks at how breathing in ozone, a common air pollutant, affects immune cells in the lungs. Healthy adults will breathe filtered air or low-level ozone and then cough up a sputum sample for analysis. The goal is to understand the body's early response to ozone, not to …

This study looks at whether a decision coach can help people aged 50-77 who smoke or used to smoke make better choices about lung cancer screening. About 594 participants will either get coaching or usual care. The goal is to see if coaching leads to better shared decisions, more…

This study looks at how tiny particles called extracellular vesicles (EVs) affect blood vessel function in people with type 2 diabetes. Researchers want to understand if exercise can change how these particles influence blood flow and metabolism. The study involves 60 adults aged…

This study aims to find genetic factors linked to pulmonary hypertension (high blood pressure in the lungs). Researchers will collect health surveys and saliva samples from 10,000 US adults aged 18 and older, both with and without the condition. Participation is online and takes …

This study collects blood and tumor samples from 1,100 people with rare or hard-to-treat cancers to look for genetic changes. The goal is to understand which gene mutations are most common and which ones might be targeted by existing drugs. This research does not provide a direct…

This study looks at whether teaching Black women about chemicals in hair products can help them make safer choices. About 120 adults who attend clean beauty events in Newark, NJ will fill out surveys before, right after, and three months later. The goal is to see if education lea…

This study looks at how hormone receptor-positive, HER2-negative breast cancer cells get their energy. Researchers will give 16 participants a special glucose (sugar) infusion before surgery, then analyze tumor and healthy tissue samples. The goal is to map the cancer's metabolic…

This study looks at how the decisions we make affect what we remember. Researchers will record brain activity from 50 epilepsy patients as they perform tasks involving choices and memory. The goal is to understand the brain processes that link decision-making and memory, which co…

This study looks at how attention and specific thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to those without. Participants will complete computer gambling tasks during brain scans and eye-tracki…

This study aims to find the best spot in the brain to stimulate with magnetic pulses (TMS) to increase reward-related brain activity in smokers. Researchers will test different targeting methods in 36 nicotine-dependent adults across three sessions. The goal is to see which targe…

This study explores whether playing a web-based game called the Breakfast Game can improve multitasking and other thinking skills in healthy adults aged 60-75. Participants will attend one educational session and 10 one-hour game sessions over a month, with follow-up tests after …

This study explores how different wording in code status questions influences the choices patients make and how doctors view those decisions. About 118 adults over 65 who can read and speak English will answer surveys through an online portal. The goal is to improve communication…

This study is testing a new training program called EMIT that helps autistic children learn to copy actions, sounds, and movements. The program is designed for children aged 5 and under with autism. Researchers want to see if EMIT can improve imitation skills, which are important…

This study tests a step-by-step manual for assessing and treating challenging behaviors like aggression and self-injury in children aged 3 to 17. Researchers will compare behavior rates during therapy and follow-up to see if the manual helps reduce these behaviors. The goal is to…

This study tests whether a non-invasive brain stimulation technique called TMS can change how the brain processes rewards during decision-making. Researchers will measure brain waves in 28 healthy adults while they perform tasks. The goal is to better understand the brain's rewar…

This pilot study aims to understand how a temporo-masseteric nerve block (TMNB) injection affects bite force and jaw muscle activity. Twenty healthy adults aged 18-64 will receive the injection on one side of the jaw. Researchers will measure bite force distribution and muscle el…

This study looks at two rare genetic conditions caused by a missing or extra piece of chromosome 3. Researchers want to learn about the medical and behavioral challenges people with these syndromes face. About 800 participants, including affected individuals and their healthy sib…

This study is creating and testing a 12-week educational program to help Black young adults (ages 18-35) who have experienced trauma and may use substances. The program aims to improve their understanding of mental health, reduce stigma, and encourage seeking help. Researchers wi…

This study tests a culturally adapted coaching program to help Hispanic smokers and former smokers decide whether to get screened for lung cancer. About 91 participants will work with bilingual patient navigators to learn about screening options. The goal is to see if this approa…

This study looks at whether a chatbot can help Black cancer survivors learn about and request genetic testing for hereditary cancer risk. About 428 participants will be randomly assigned to either use the chatbot or receive standard care. The goal is to see which approach leads t…

This study trains high school students to become health advocates and encourage their adult family members to get screened for cancer. Researchers will see if this youth-led approach increases screening rates among adults who are overdue. About 84 teens and their adult relatives …

This study looks at children aged 3 to 17 who have frequent problem behaviors like aggression or self-injury. Researchers want to understand why these behaviors sometimes get worse at the start of a new therapy, a pattern called an extinction burst. By observing 40 children, they…

This study aims to understand how genes influence kidney disease risk. Anyone 18 or older living in the US can join, even if they don't have kidney disease. Participants fill out online health surveys and provide a saliva sample by mail. In return, they may receive free informati…

This study collects stories from doctors, nurses, and social workers who have worked in newborn intensive care units (NICUs) to understand how treatment decisions were made over time. Researchers will interview 15 people and use the recordings to write a book about the history of…

This study tests whether a computer model can predict which reading therapy works best for people who developed dyslexia after a stroke. Twelve participants will receive two different types of intensive reading therapy, and researchers will compare the results to the model's pred…

This study looks at whether charcoal-filtered cigarettes change how people smoke and their exposure to harmful chemicals. About 252 adult smokers who smoke at least 5 cigarettes daily will be randomly assigned to use either charcoal-filtered or regular cigarettes for 4 weeks. Res…

This study looks at why premature babies have sudden drops in oxygen levels. Researchers will monitor lung function continuously in 35 preterm infants to identify different causes, such as pauses in breathing or loss of lung air. The goal is to better understand these episodes so…

This study tests a digital tool called mySmartSkin to help melanoma survivors do better skin self-exams. About 385 people who had melanoma will use the app and report how thoroughly they check their skin. The goal is to see if the app helps catch new or returning melanomas earlie…

This study looks at how pancreatic cancer cells get and use nutrients to survive. Researchers will give a special sugar (U-13C-glucose) to 16 adults during surgery to trace the cancer's energy use in the lab. The goal is to find weaknesses that could lead to new treatments. Parti…

This study looks at how body composition (like weight and muscle) affects the way immunoglobulin G (IgG) is processed in people with CIDP, a nerve disorder. Researchers will give IgG through a vein or under the skin and measure drug levels and half-life. The goal is to improve do…

This study tests whether a non-invasive brain stimulation technique called TMS can change brain activity related to spatial navigation. About 60 healthy adults will play virtual maze games while their brain waves are recorded. The goal is to see if TMS can boost or reduce a speci…

This study is testing a training program called DECIDE for healthcare providers who care for pregnant and new mothers with mental health conditions. The training teaches providers how to communicate better and make shared decisions with their patients. Researchers will ask 35 pro…