Ruijin Hospital

This study compares two treatment schedules for people with a common type of lymphoma (DLBCL) that is low-risk and hasn't spread. Participants will receive either 4 cycles of R-CHOP followed by 4 doses of rituximab, or 6 cycles of R-CHOP followed by 2 doses of rituximab. The goal…

This study tests a new drug called sonrotoclax combined with standard chemotherapy and other targeted medicines for adults who have just been diagnosed with acute myeloid leukemia (AML). About 205 participants will receive different combinations based on their genetic markers. Th…

This study tests whether adding an immunotherapy drug (PD-1 inhibitor) to a standard treatment plan (short-course radiation, chemotherapy, and a targeted therapy) can improve outcomes for people with locally advanced rectal cancer. About 104 adults with a specific type of rectal …

This study tests a new drug combination (HRS-4642 plus chemotherapy and an immunotherapy) in 30 people with pancreatic cancer that can be surgically removed. The goal is to see if the treatment shrinks tumors before surgery and prevents return after surgery. Participants will rec…

This early-phase study tests a new treatment called RXIM002 for people with severe autoimmune diseases that haven't responded to standard therapies. The treatment uses a special RNA molecule to create CAR T-cells inside the body that target and destroy faulty immune cells. The ma…

This study tests whether a chemotherapy combination using oxaliplatin plus S-1 works as well as docetaxel plus S-1 for people with stage III stomach cancer who have had surgery. About 387 adults will be randomly assigned to one of the two treatments. The goal is to see which comb…

This early-phase study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't responded to standard therapies. The treatment works by directing the body's immune cells to attack harmful immune cells. The main goal is to check safety and find t…

This study tests a new treatment for people with pancreatic cancer that has spread to the liver. The approach uses a multi-step process: first, a baking soda solution is infused into the liver to make the tumor environment less acidic, then chemotherapy and an immunotherapy drug …

This study tests a combination of four drugs (Pola-ZR-Glo) in 30 older adults (70+) with untreated large B-cell lymphoma who are too frail for standard chemo. The goal is to see if this gentler approach can control the cancer and improve quality of life. Researchers will track ho…

This study tests a combination of three drugs (orelabrutinib, selinexor, and either methotrexate or alternatives) for people with central nervous system lymphoma that has returned or not responded to prior therapy. The goal is to see if this mix can shrink tumors and delay progre…

This study is for people with a fast-growing type of blood cancer called mantle cell lymphoma that has not been treated yet. It tests a combination of three drugs (orelabrutinib, lisaftoclax, and rituximab) to see how well they shrink tumors and how safe they are. About 25 partic…

This study tests a new treatment for people with locally advanced pancreatic cancer that has stopped responding to standard chemotherapy. The approach combines cryoablation (freezing the tumor) with a drug called Apalulizumab that helps the immune system attack cancer cells. The …

This study tests whether adding targeted drugs based on a patient's genetic profile to standard chemotherapy (Pola-RCHP) works better than standard chemo alone for people with untreated diffuse large B-cell lymphoma. About 152 adults aged 18-75 with an IPI score of 2-5 will parti…

This study tests a combination of four drugs (cadonilimab, LM-302, S-1, and paclitaxel) in 40 people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the abdomen lining. The goal is to see if this treatment can improve survival and shrink…

This study compares two medications, firsekibart and anakinra, to see which works better and is safer for people with Adult-Onset Still's disease (AOSD), a rare inflammatory condition. About 20 adults aged 18 to 75 with confirmed AOSD will take one of the two drugs. The main goal…

This study tests a new treatment for people with locally advanced pancreatic cancer whose first chemotherapy (AG) stopped working. The treatment combines a procedure that uses electrical pulses to destroy tumor cells (IRE) with a drug that helps the immune system attack the cance…

This study is for people with early-stage nasal-type NK/T-cell lymphoma who have not had treatment before. It tests a personalized approach using a PD-1 antibody drug combined with radiation therapy. The goal is to control the disease while reducing side effects. About 47 partici…

This study is testing a freezing technique called cryoablation to treat small lung nodules that are early-stage lung cancer. It is for people who cannot have surgery due to age, health problems, or having multiple nodules. The goal is to see if this minimally invasive treatment c…

This study tests whether using PET scans and Epstein-Barr virus (EBV) DNA levels during treatment can help doctors choose the best therapy for people with a rare nasal lymphoma (NK/T-cell). About 89 adults with early-stage disease will receive treatment guided by these tests. The…

This study tests whether giving chemotherapy plus an immunotherapy drug before surgery can help people with locally advanced colon cancer. About 56 adults with a specific type of colon cancer will receive the treatment and then have standard surgery. The main goal is to see if th…

This study is for people newly diagnosed with a type of blood cancer called mantle cell lymphoma that is not considered high-risk. It tests a combination of two drugs (orelabrutinib and rituximab) and may include a stem cell transplant using the patient's own cells. The goal is t…

This study is testing a new, less invasive way to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve). About 180 participants will receive either the new VitaFlow valve system or a standard device. The goal is to see if the new system reduces…

This study is testing a less invasive treatment for a serious tear in the main artery near the heart, specifically for people who are too high-risk for open-heart surgery. About 149 participants will receive a stent placed through a blood vessel to repair the tear. Researchers wi…

This study compares different lengths of maribavir treatment for CMV infection that doesn't respond to standard therapy in adults who had a stem cell transplant. About 218 participants will receive maribavir for either a shorter or longer period to see which better prevents the i…

This study tests whether taking a daily low dose of colchicine (a drug usually used for gout) for one year after coronary artery bypass grafting (CABG) can reduce the chance of the new blood vessels (grafts) failing. About 100 adults who recently had bypass surgery will take colc…

This study tests a personalized treatment approach for people with untreated marginal zone lymphoma, a slow-growing blood cancer. About 145 participants will receive targeted therapy based on their individual risk score. The goal is to see if this tailored treatment can keep the …

This early-stage study tests a new treatment called PDR-001 for people with Parkinson's disease. The treatment is a peptide delivered directly into the brain to clear a harmful protein called alpha-synuclein, which is linked to Parkinson's. The main goal is to check safety in 12 …

This study tests whether a combination of two drugs (sintilimab and bevacizumab biosimilar) can help prevent liver cancer from coming back after surgery in people whose tumor had ruptured. About 35 adults with this high-risk condition will receive the treatment. The goal is to se…

This study tests whether giving a special immune cell treatment (CD19 CAR-T) right after a stem cell transplant can help people with a hard-to-treat type of lymphoma. It includes 16 adults whose lymphoma has come back or not responded to standard treatments. The main goal is to s…

This study tests whether a donor stem cell transplant after chemotherapy can prevent leukemia from coming back in people with a high-risk type of acute myeloid leukemia. About 90 newly diagnosed adults will receive one round of chemo, then two more rounds, followed by a transplan…

This study tests a combination of drugs (LM-302, S-1, and intraperitoneal paclitaxel) with or without another drug (cadonilimab) in people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the lining of the abdomen. The goal is to see if t…

This study tests two drug combinations given before surgery for people with a specific type of advanced stomach or gastroesophageal junction cancer that has a protein called claudin 18.2. About 88 participants will receive either tislelizumab plus LM-302 and S-1, or tislelizumab …

This early-phase study tests a personalized mRNA vaccine (XP-004) combined with a PD-1 inhibitor in 20 patients who had pancreatic cancer surgery but cannot tolerate chemotherapy. The vaccine is designed to train the immune system to recognize and attack the patient's specific tu…

This study is testing whether a special PET/MR scan can better identify risky plaque buildup in the carotid arteries (the main arteries in the neck) that could lead to a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with an MRI to meas…

This study explores whether a new type of PET scan tracer can help doctors see lung and kidney problems in people with ANCA-associated vasculitis, a rare autoimmune disease. The tracer targets specific cells linked to tissue scarring. Researchers will scan 30 adults to see if thi…

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to measure how the drug moves through the body and check for side effects, not to treat the disease. Participants receive one of th…

This study is training an artificial intelligence system to recognize different parts of the throat and detect abnormal growths (lesions) from standard scope images. Researchers will collect 500 sets of images from patients undergoing a nasopharyngolaryngoscopy. The goal is to se…

This study looks at whether analyzing how people with dystonia walk before deep brain stimulation (DBS) surgery can predict how well the surgery will work. About 50 adults scheduled for DBS will wear small movement sensors while walking. Researchers will then compare walking patt…

This study follows 640 people—including those with Parkinsonism, a sleep disorder called REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers use brain scans, blood tests, and movement assessments to see how the diseases progress and to improve diagnosis. …

This study looks at whether measuring blood flow in the gut can help predict feeding intolerance in critically ill patients. Researchers will monitor 500 adults in the ICU who need tube feeding for at least 7 days. The goal is to build a model that uses blood flow data to identif…

This study looks at whether a deep inspiration breath-hold (DIBH) technique during radiation therapy for breast cancer patients keeps the radiation dose on target and protects nearby organs. About 25 women who had breast surgery and need chest radiation will participate. Research…

This study will test if an artificial intelligence (AI) system can safely guide a robot to find lung nodules during a bronchoscopy. Twenty adults with lung nodules will be enrolled. The goal is to see how often the AI can work on its own without a doctor stepping in, and to check…

This study is following 600 people with Parkinson's disease and 100 with multiple system atrophy over time. Researchers are collecting medical history, biological samples, brain scans, and regular check-ups every six months. The goal is to find early signs of disease, improve dia…