Ruijin Hospital

This early-phase study tests a new treatment called RXIM002 for people with severe autoimmune diseases that have not responded to standard therapies. RXIM002 uses circular RNA to create CAR T-cells inside the body that target and destroy faulty B cells. The main goals are to chec…

This early-stage study tests a new drug called PDR-001 in 12 people with Parkinson's disease. The treatment is injected directly into a brain area to clear clumps of a protein called alpha-synuclein, which is thought to drive the disease. The goal is to see if it is safe and migh…

This study tests a new combination of drugs (sonrotoclax, azacitidine, and other targeted medicines) in 205 adults with newly diagnosed acute myeloid leukemia. The goal is to see if this mix can achieve complete remission and reduce cancer cells to undetectable levels. Participan…

This study tests a new treatment for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The approach combines cryoablation (freezing the tumor) with a drug called Apalulizumab that helps the immune system attack cancer cells. The goal is to se…

This early-phase study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy uses mRNA to produce a protein that helps the immune system attack harmful cells. The main goal is to check safety and toler…

This study tests whether combining two drugs (sintilimab and bevacizumab) after surgery can prevent liver cancer from coming back in patients whose tumor ruptured. About 35 adults with this rare, high-risk condition will receive the treatment. The goal is to see if this approach …

This study tests whether a new drug, firsekibart, works better than the current drug anakinra for people with Adult-Onset Still's disease (AOSD), a rare inflammatory condition. About 20 adults aged 18 to 75 with confirmed AOSD will receive either drug for 24 weeks. The main goal …

This study tests a new drug (HRS-4642) combined with standard chemotherapy and an immunotherapy for people with pancreatic cancer that can be surgically removed. The treatment is given before surgery to shrink the tumor and after surgery to prevent return. About 30 adults aged 18…

This study tests whether adding targeted drugs based on a patient's genetic profile to standard chemotherapy (Pola-RCHP) works better than standard chemo alone for people with untreated diffuse large B-cell lymphoma. About 152 adults aged 18-75 with intermediate-to-high risk dise…

This study tests whether a daily low dose of colchicine, a medicine usually used for gout, can help prevent the failure of bypass grafts in people who have had coronary artery bypass surgery (CABG). About 100 adults will take colchicine for one year after surgery and have CT scan…

This study tests a combination of two drugs (orelabrutinib and rituximab) in people with a slow-growing form of mantle cell lymphoma who have not had treatment before. Some participants may also receive a stem cell transplant using their own cells. The goal is to see how well the…

This study tests a combination of four drugs (cadonilimab, LM-302, S-1, and paclitaxel) in 40 people with a specific type of advanced stomach cancer that has spread to the lining of the abdomen. The goal is to see if this treatment can help patients live longer and shrink the can…

This study tests whether giving a special immune cell treatment (CD19 CAR-T) right after a stem cell transplant can help people with hard-to-treat B-cell lymphoma. The trial includes 16 adults whose lymphoma has come back or not responded to standard treatments. The main goal is …

This study is testing a new type of PET scan tracer (68Ga-FAPI) to see if it can better detect lung scarring and kidney problems in people with ANCA-associated vasculitis, a rare autoimmune disease. The tracer targets specific cells involved in tissue damage, allowing doctors to …

This study is developing an artificial intelligence (AI) system to help doctors identify abnormal areas in the throat and voice box during routine camera exams. Researchers will collect images from 500 patients and train the AI to recognize different parts of the throat and spot …

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD), a type of lung scarring. The goal is to measure how much drug gets into the blood and lungs, and to check for side effects over 7 days. No trea…