Ruijin Hospital

This study looks at whether sirolimus, a drug that calms the immune system, can help people with Adult-Onset Still's disease that hasn't improved with standard treatments. Three adults with this rare inflammatory condition will take sirolimus pills for 12 weeks while doctors moni…

This study tests whether adding two drugs (camrelizumab and apatinib) to standard chemotherapy before surgery can help shrink tumors in people with advanced stomach or gastroesophageal junction cancer. About 80 participants will receive the treatment before their planned surgery.…

This study aimed to see if taking two blood-pressure medicines (isosorbide mononitrate and amlodipine) for 24 weeks after heart bypass surgery could prevent the radial artery graft from failing. It planned to enroll adults who had just received a radial artery graft during bypass…

This study tests a one-week course of radiation for breast cancer patients who need treatment to the chest or breast and nearby lymph nodes. The goal is to see if this shorter approach is safe and effective at controlling the disease. About 197 participants will be followed for a…

This early-phase trial tests the safety and effectiveness of a new drug called CS01 in up to 10 people with advanced solid tumors that have not responded to standard treatments. The study has two parts: first finding a safe dose, then checking if the drug can shrink tumors. It is…

This study tests a drug called TMF (amibufenamide) in 200 adults with chronic hepatitis B who have normal liver enzyme (ALT) levels. The goal is to see if TMF can lower the amount of hepatitis B virus in the blood to undetectable levels after 48 weeks. Participants are randomly a…

This study compares three oral medications (nicorandil, diltiazem, and isosorbide mononitrate) to prevent spasms in radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had this surgery will take one of the drugs for 24 weeks, with follow-up …

This study looks at how well a treatment called CNCT-19 works for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). Researchers will review medical records from 275 patients in China to see how many achieve remission and how long it lasts. The g…

This study tests whether adding the immunotherapy drug camrelizumab to standard chemotherapy and apatinib can improve outcomes for people with stomach or gastroesophageal junction cancer. About 580 adults with locally advanced but removable tumors will receive the treatment befor…

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into more serious brain diseases like Parkinson's. About 142 adults with iRBD will receive either idebenone or a placebo for up to 5 years. Researchers will track how m…

This study tests whether a blood test that measures CMV-specific immunity can help doctors decide how long to use the antiviral drug letermovir after a stem cell transplant. The goal is to prevent late-onset CMV infection, a common complication. The trial involves 250 adults rece…

This study looks at a new method called UFR to find significant blockages in heart arteries. It involves 112 adults with suspected heart disease. The goal is to see if UFR works as well as the current standard test (FFR) to guide treatment decisions.

This study tests if a natural oil (palmitoleic acid) applied to the skin can prevent pressure injuries (bedsores) in 60 hospital patients at high risk. Researchers will use special scanners to detect early signs of skin damage before it becomes visible. The goal is to see if the …

This study tests a new type of brain stimulation for people with depression that hasn't improved with standard treatments. Ten adults will receive both active and sham (fake) stimulation in random order to see if the real treatment reduces symptoms. The goal is to find a safe and…

This study tests a non-invasive brain stimulation technique called tTIS to see if it can improve movement problems in people with early to mid-stage Parkinson's disease. Researchers will compare two different brain targets (STN and GPi) in the same person to find which works bett…

This study tests a new, non-invasive brain stimulation method called Temporal Interference Stimulation (TIS) in 40 people with early-stage Alzheimer's. Participants will receive either real TIS or a sham (fake) treatment for 2 weeks. Researchers will check thinking skills and saf…

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) aimed at the right amygdala to quickly reduce depression symptoms. Fifty adults with major depressive disorder will receive either real or sham stimulation over…

This study looks back at medical records of 102 adults with B-cell acute lymphoblastic leukemia who received the drug inotuzumab ozogamicin. The goal is to see how well the drug worked and how safe it was in different patient groups. No new treatments are given; researchers simpl…

This study involves 792 people who need heart valve surgery and also have blocked coronary arteries. Researchers are comparing two ways to decide which blockages to treat during surgery: standard angiography (X-ray dye pictures) versus a newer computer analysis called Quantitativ…

This study creates a new tool called the SAH Index to fairly compare how well different hospitals perform gastric cancer surgery. Researchers analyzed medical records from 780 patients who had surgery in 2019, considering factors like age, tumor type, and genetic markers. The goa…

This study looks at 120 adults with severe breathing failure (ARDS) who are on a ventilator. Researchers use a non-invasive imaging tool called electrical impedance tomography (EIT) to watch how air and blood flow move through the lungs over time. The goal is to see if different …

This study aims to create a new way to diagnose interstitial lung disease (ILD) in people with dermatomyositis, a rare muscle condition. Researchers will use special PET/CT scans and machine learning to find patterns that predict ILD. The study involves 200 adults and compares th…

This study looks at whether a special imaging technique called Electrical Impedance Tomography (EIT) can help doctors know if high-flow oxygen therapy will stop working within 48 hours. About 90 adults with acute breathing problems will be monitored. The goal is to find a better …

This study looks at a gene called TRIM25 in blood cells from 65 hospitalized adults with and without sepsis. By comparing gene activity and inflammatory markers, researchers hope to find new ways to diagnose and treat sepsis. Participants give blood samples, and no experimental t…