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Heart bypass graft drug combo trial pulled before it began

NCT ID NCT06730945

Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study planned to test whether taking two blood vessel-relaxing drugs (isosorbide mononitrate and amlodipine) for 24 weeks after coronary bypass surgery could prevent failure of the radial artery graft. The trial was withdrawn before enrolling any participants, so no data were collected. The intended participants were adults who had just received a radial artery graft during bypass surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
isosorbide mononitrate and amlodipine
What this could lead to
If it had worked, this could point toward a simple oral treatment to keep radial artery grafts open longer after bypass surgery.
What could go wrong
The trial was withdrawn before any participants enrolled, so no results are available. Even if conducted, the treatment might not reduce graft failure and could cause low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Expected to start

Jun 2025

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age≥18 years old， * Any sex， * Signed informed consent， * Within 3 days after primary isolated CABG using RA graft Exclusion Criteria: 1. Allergy to isosorbide mononitrate or amlodipine. 2. Hypotension (systolic BP \<90 mmHg or diastolic BP \<60 mmHg) 3. Acute myocardial infarction or cardiogenic shock 4. Contraindications for CCTA examination (eg., iodine allergy)

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery bypass graft surgery (CABG) Graft failure Radial artery grafts

Contacts and locations

Locations

  • Ruijin Hospital Shanghai Jiao Tong University School of Medicine

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.