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Triple-Drug attack before surgery shows promise for tough stomach cancers

NCT ID NCT04208347

First seen Jan 28, 2026 · Last updated May 01, 2026 · Updated 17 times

Summary

This study tests whether adding two newer drugs (apatinib and camrelizumab) to standard chemotherapy before and after surgery can improve outcomes for people with advanced stomach or gastroesophageal junction cancer. About 580 adults with previously untreated, locally advanced disease will be randomly assigned to receive either chemotherapy plus apatinib or all three drugs. The main goals are to see if the cancer disappears completely after treatment and to measure how long patients live without the cancer returning.

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Contacts and locations

Locations

  • Affiliated Hospital of Hebei University

    Baoding, China

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, China

  • Cancer Hospital Chinese Academy of Medical Sciences

    Beijing, China

  • Cancer Hospital of the University of Chinese Academy of Sciences

    Hangzhou, China

  • Changhai Hospital

    Shanghai, China

  • First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, China

  • Hainan Cancer Hospital

    Haikou, China

  • Hefei Cancer Hospital, Chinese Academy of Sciences

    Hefei, China

  • Henan Provincial Cancer Hospital

    Zhengzhou, China

  • Heping Hospital Affiliated to Changzhi Medical College

    Changzhi, China

  • Jilin Guowen Hospital

    Siping, China

  • Lanzhou University Second Hospital

    Lanzhou, China

  • Liaoning Cancer Hospita & Institute

    Shenyang, China

  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, China

  • Shanxi Provincial Cancer Hospital

    Taiyuan, China

  • Sichuan Cancer Hospital & Institute

    Chengdu, China

  • Sichuan Provincial People's Hospital

    Chengdu, China

  • Tangdu Hospital

    Xi'an, China

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, China

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, China

  • The Second Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, China

  • Xiangya Hospital Central South University

    Changsha, China

  • Yantai Yuhuangding Hospital

    Yantai, China

Conditions

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