Ruijin Hospital

This early-stage study tests a personalized mRNA vaccine (XP-006) for people with B-cell non-Hodgkin's lymphoma that has come back or not responded to standard treatments. The vaccine is custom-made to train the immune system to attack each patient's unique tumor. The main goal i…

This study tests a new drug called zanubrutinib combined with chemotherapy for people newly diagnosed with central nervous system lymphoma. About 19 participants will receive the treatment, and those who respond well will continue zanubrutinib for 2 years to keep the disease unde…

This study tests whether a new drug called golidocitinib, when combined with standard chemotherapy (GemOx), can shrink tumors in people whose peripheral T-cell lymphoma has returned or stopped responding to treatment. About 31 adults will receive the combination and be monitored …

This study compares a new 1-week radiation schedule (ultra-hypofractionated) to the standard 3-week schedule for treating lymph nodes after breast cancer surgery. It aims to see if the shorter treatment is just as effective at preventing cancer from coming back. About 1,950 adult…

This study is testing a new vaccine called KSD-101 for people with blood cancers linked to the Epstein-Barr virus (EBV). The vaccine is designed to train the body's immune system to attack cancer cells. The goal is to see if it can shrink tumors or keep the cancer from coming bac…

This study tests whether adding the experimental drug BEBT-908 to standard chemotherapy can eliminate leftover cancer cells in adults with a specific, high-risk form of acute lymphoblastic leukemia (ALL). Participants must be in remission but still have tiny amounts of disease de…

This study tests a personalized treatment for people with a rare and aggressive blood cancer called peripheral T-cell lymphoma (PTCL) that did not respond to initial chemotherapy. Doctors will use genetic testing of the tumor to select a combination of drugs, including an experim…

This early-phase study will test a new drug, cizutamig, in 10 adults with systemic sclerosis, a condition that causes skin hardening and organ damage. The main goal is to check if the drug is safe and tolerable, while also looking at how the body processes it and whether it shows…

This study tests a new combination of drugs for people aged 65 and older with a fast-growing type of lymphoma called double/triple-hit diffuse large B-cell lymphoma. Participants will receive six cycles of the CL-Pola-R-CHP regimen, which adds two newer drugs to a standard chemot…

This early-phase study tests a new cell therapy called GI001 in 9 adults with B-cell Non-Hodgkin Lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to target and kill cancer cells. The main goals are to check safety …

This study tests whether combining two powerful treatments—glofitamab and CAR-T cell therapy—can help people with a high-risk form of large B-cell lymphoma that has come back or not responded to prior treatment. About 24 participants will receive the combination and be monitored …

This early-stage study tests a combination of three drugs (sonrotoclax, zanubrutinib, and obinutuzumab) as a first treatment for people newly diagnosed with an aggressive form of mantle cell lymphoma. About 28 adults with high-risk features will receive the therapy to see how wel…

This study tests a new drug called QL1706 combined with chemotherapy for people with a type of esophageal cancer that is hard to remove completely with surgery. The goal is to shrink the tumor before surgery and then continue treatment afterward to improve long-term outcomes. Abo…

This study tests two drug combinations for people with stomach cancer that has spread to the lining of the abdomen (peritoneal metastasis). The experimental drug SHR-1701 is added to chemotherapy to see if it helps patients live longer and possibly become eligible for surgery. Ab…

This early-stage study tests a new drug, GB261, in 10 adults with systemic sclerosis, a condition that causes skin and organ hardening. The main goal is to check safety and how the body handles the drug. Researchers will also look for early signs that the drug might help control …

This study looks at a new way to give radiation to children with brain tumors that need whole-brain and whole-spine treatment. The technique, called vertebral body-sparing proton therapy, aims to protect the front of the spine bones to preserve bone marrow and growth. Researchers…

This study tests an experimental pill, gimacabtinib, in 15 adults with severe graft-versus-host disease (GVHD) after a stem cell transplant. Participants must have already tried and failed or not tolerated a standard second-line treatment. The goal is to see if the drug can contr…

This study tests a combination of three drugs (tazemetostat, linperlisib, and golidocitinib) in people with a type of blood cancer called peripheral T-cell lymphoma that has come back or not responded to treatment. The goal is to see if the combination can shrink tumors and contr…

This study tests a new treatment for people with a fast-growing type of lymphoma called double-expressor DLBCL. It compares a standard chemo-immunotherapy regimen (CR-CHOP) to a newer combination (C Pola R-CHP+X) chosen based on each patient's genetic profile. The goal is to see …

This study looks at whether giving a short course of hydrocortisone (a steroid) after removing an adrenal gland can help slow kidney function decline in people with primary aldosteronism (a hormone problem causing high blood pressure) who also have chronic kidney disease. About 9…

This study tests a new drug called cadonilimab given together with standard radiation therapy for people with advanced cervical cancer who cannot receive chemotherapy due to age or health problems. The goal is to see if this combination can make the cancer disappear completely. A…

This study tests whether an AI-driven treatment plan works better than standard therapy for people with untreated large B-cell lymphoma. About 178 participants will be grouped by risk using AI, then receive either a personalized combination of drugs or the usual treatment. The go…

This study tests a new drug called IBI363 combined with chemotherapy for people with advanced pancreatic cancer that has worsened after initial treatment. About 48 participants will receive the combination until their disease progresses or side effects become too severe. The goal…

This early-phase study tests a new drug, cizutamig, in 15 adults with moderate to severe ulcerative colitis who have not responded to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will monitor side effects throughout the study.

This study tests whether using bedside ultrasound to guide suctioning of the throat area can make the procedure safer and more effective for patients on breathing machines. About 321 ICU patients expected to need a breathing tube for at least 72 hours will take part. The goal is …

This study compares two types of radiation therapy—proton and photon—given after breast cancer surgery. The goal is to see which one causes fewer side effects to the heart, lungs, skin, and other organs. About 750 women will be followed for at least a year to track complications …

This study tests a special PET scan that looks for a protein called Claudin18.2 on pancreatic and stomach cancer cells. The goal is to see if this scan can accurately find the protein, helping doctors choose the right targeted treatment for each patient. About 64 adults with thes…

This study tests two special formulas (amino acid and extensively hydrolyzed) in 360 infants aged 0-6 months with suspected cow's milk protein allergy. The goal is to see which formula better relieves symptoms like diarrhea, vomiting, and skin issues during a 2-week diet trial. R…

This study tests whether spinal cord stimulation can help people with Parkinson's disease who experience sudden drops in blood pressure when standing up. The trial will compare two types of stimulation—one implanted and one non-invasive—in 40 adults aged 40-80. The goal is to fin…

This study looks at whether a partially broken-down whey protein formula can help infants with mild allergy symptoms like skin rashes or tummy troubles. About 160 babies aged 3-5 months will be randomly assigned to get either the special formula or a standard cow's milk formula. …

This study tests whether a new antiviral pill, onradivir, can help teenagers aged 12 to 17 recover faster from the flu. About 150 teens with uncomplicated influenza A will take either the medicine or a placebo once daily for five days. Researchers will track how quickly symptoms …

This study looks at how well proton radiation targets breast cancer after surgery. Researchers will use PET/CT scans to measure beam accuracy and see if errors lead to side effects like lung inflammation or rib fractures. About 30 women will join to help improve future treatment …

This study will collect blood and sputum samples from 411 adults with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers will analyze the samples to find biological markers that can predict how well patients respond to ventilation and their cha…

This study will collect medical information from 1,000 people newly diagnosed with lymphoma. Researchers will track how long patients live without the disease getting worse and overall survival. The goal is to learn which treatments work best in real-world settings.

This study aims to create a computer program that can predict delirium in ICU patients by analyzing their facial expressions and other biological features. Delirium is a sudden confusion that often goes undiagnosed. The researchers will enroll about 795 adults in the ICU and use …

This study looks at whether a new ultrasound-based risk score can better predict pressure injuries (bedsores) in critically ill patients in the ICU. In the first phase, researchers will check how accurate the score is. In the second phase, some patients will get special care base…