New hope for hepatitis b patients with normal ALT: TMF trial underway
NCT ID NCT05797714
First seen Nov 17, 2025 · Last updated May 24, 2026 · Updated 23 times
Summary
This study tests a drug called TMF (amibufenamide) in 200 adults with chronic hepatitis B who have normal liver enzyme (ALT) levels. The goal is to see if TMF can lower the amount of hepatitis B virus in the blood to undetectable levels after 48 weeks. Participants are randomly assigned to receive TMF or no treatment, and researchers will also check for loss of hepatitis B surface antigen, which indicates better disease control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beijing You'An Hospital, Capital Medical University
Beijing, China
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Fuyang Second People's Hospital
Fuyang, China
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Jiangsu Province Hospital
Nanjin, China
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LiShui People's Hospital of Zhejiang Province
Lishui, China
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People's Hospital of Dongyang City
Dongyang, China
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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai, China
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Shanghai East Hospital
Shanghai, China
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The Fifth People's Hospital of Suzhou
Suzhou, China
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The Fifth People's Hospital of Wuxi
Wuxi, China
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The First Affiliated Hospital of Nanchang University
Nanchang, China
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The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang Province
Hangzhou, China
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The Second Xiangya Hospital, Central South University
Changsha, Hunan, China
Conditions
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