New hope for hepatitis b patients with normal ALT: TMF trial launches

NCT ID NCT05797714

First seen Nov 17, 2025 · Last updated May 07, 2026 · Updated 20 times

Summary

This study tests a drug called TMF (Amibufenamide) in 200 adults with chronic hepatitis B who have normal ALT levels. The goal is to see if TMF can lower the amount of hepatitis B virus in the blood and possibly clear a key marker of infection (HBsAg). Participants are randomly assigned to receive TMF or no treatment, and results are checked after 48 weeks.

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Contacts and locations

Locations

  • Beijing You'An Hospital, Capital Medical University

    Beijing, China

  • Fuyang Second People's Hospital

    Fuyang, China

  • Jiangsu Province Hospital

    Nanjin, China

  • LiShui People's Hospital of Zhejiang Province

    Lishui, China

  • People's Hospital of Dongyang City

    Dongyang, China

  • Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

    Shanghai, China

  • Shanghai East Hospital

    Shanghai, China

  • The Fifth People's Hospital of Suzhou

    Suzhou, China

  • The Fifth People's Hospital of Wuxi

    Wuxi, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, China

  • The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang Province

    Hangzhou, China

  • The Second Xiangya Hospital, Central South University

    Changsha, Hunan, China

Conditions

Explore the condition pages connected to this study.