CHRONIC HEPATITIS B

This large observational study aims to find the best treatment plans for chronic hepatitis B by tracking the health of 15,000 patients across China. Researchers will compare different antiviral medications to see which ones are most effective at lowering the risk of developing li…

This study is observing whether adding a specific gut bacteria (Bacteroides fragilis) and branched-chain amino acids to standard antiviral therapy helps people with chronic hepatitis B clear the virus. Researchers will compare the virus clearance rate in 40 patients receiving thi…

This study is testing a new oral drug called Neracorvir (GST-HG141) for people with chronic hepatitis B who are still showing signs of the virus despite taking standard antiviral pills. Over 500 participants will be randomly assigned to receive either the new drug or a placebo, i…

This study is testing how a new drug called Imdusiran works in the liver of people with chronic hepatitis B. Ten participants will receive four injections over several months while continuing their regular antiviral pills. Researchers will perform liver biopsies to measure how mu…

This study is testing a new combination of two drugs (an immune therapy and interferon) to help people with chronic hepatitis B achieve a 'functional cure.' The goal is for patients to stop all hepatitis B medications and maintain control of the virus long-term. Researchers are e…

This study aims to test the safety and effectiveness of a medication called tenofovir alafenamide (TAF) for children and teenagers with chronic hepatitis B. It will enroll 150 participants to compare the drug against a placebo for 24 weeks, followed by longer-term monitoring. The…

This study is testing whether a new injectable drug called HRS-5635, given alone or with other medications, can help control chronic hepatitis B. It will involve 369 adults who already have the virus under control with standard pills. Researchers will check if the new treatment c…

This 5-year study is testing if a common diabetes medication, dapagliflozin, can prevent serious liver complications like cancer and liver failure in people who have both chronic hepatitis B and diabetes. About 412 participants will be randomly assigned to take either the real dr…

This study is testing whether a combination of two injectable drugs can help control chronic Hepatitis B infection. It will involve about 50 adults with a mild or inactive form of the disease. Participants will receive monthly and weekly injections over six months, with the goal …

This study is testing an experimental injection called AHB-137 in people who already take standard pills for chronic hepatitis B. The goal is to see if the new treatment can further reduce the amount of virus in the blood and strengthen the body's immune response against it. Abou…

This study is testing whether azvudine tablets can provide long-term control of chronic hepatitis B. It will involve 120 participants who have not had prior antiviral treatment. Researchers will monitor virus levels, liver function, and immune response over 12 months to see if th…

This study is testing a new combination of drugs to try and achieve a 'functional cure' for chronic Hepatitis B, meaning the virus is undetectable and controlled by the immune system without ongoing medication. It will involve 120 adults with Hepatitis B who are already on standa…

This early-stage study is checking if a vaccine normally used to prevent hepatitis B is safe for people who already have a long-term infection. Researchers will give two vaccine shots to 10 adults whose infection is currently controlled with medication. The main goal is to see wh…

This is an early safety study for a new injection called SA1211. It aims to see if the shot is safe, how the body processes it, and if it shows any early signs of helping people with chronic hepatitis B. The study will involve 80 people, including healthy volunteers and those wit…

This large, real-world study aims to find out which antiviral treatments work best for adults with chronic hepatitis B over the long term. Researchers will follow 33,000 patients for up to 5 years to see which drug regimens are most effective at preventing liver cancer and helpin…

This early-stage trial is testing a new drug called Tune-401 in adults with chronic hepatitis B. The main goal is to check if the drug is safe and how the body processes it. Researchers will also measure how it affects the hepatitis B virus in participants who are already taking …

This study is testing whether a special type of MRI scan, called magnetic resonance elastography (MRE), can accurately measure liver scarring (fibrosis) in people with chronic Hepatitis B. The goal is to find a better, non-invasive way to monitor the disease over time, potentiall…

This study is testing a drug called TAF in pregnant women who have hepatitis B. The main goal is to see if taking TAF during pregnancy can safely prevent the mother from passing the hepatitis B virus to her baby. Researchers will also measure how much of the drug gets into the mo…