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Double liver trouble: does having both hepatitis b and fatty liver speed up disease?

NCT ID NCT02863757

Knowledge-focused Sponsor: Humanity and Health Research Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study follows 1500 Chinese adults with chronic hepatitis B, nonalcoholic fatty liver disease, or both, to see how having both conditions changes the risk of serious liver problems like cirrhosis, liver failure, and liver cancer. Researchers will track who develops these complications and when. The goal is to understand whether the combination of the two liver diseases leads to faster or more severe disease progression than having either one alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study clarifies how having both hepatitis B and fatty liver disease affects liver health, it could guide better monitoring and treatment strategies for these patients.
What could go wrong
This is an observational study, not a treatment trial, so it will not test any new therapy. The results may show associations but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2016

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Hosptials and primary care clinics

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Liver biopsy proved CHB and/or NAFLD at baseline; * Chinese * Follow-up duration\>12 months Exclusion Criteria: * Other liver diseases; * Secondary causes of hepatic steatosis; * Alcohol abuse; * Liver cirrhosis, cirrhosis related complications or HCC at baseline; * Malignancy; * History of liver transplantation

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic hepatitis B Nonalcoholic fatty liver disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Humanity and Health GI and Liver Centre

    RECRUITING

    Hong Kong, Hong Kong, 00852, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.