Roswell Park Cancer Institute

This study is testing whether adding an oral antiviral drug called lamivudine to the standard first-line treatment (chemotherapy plus immunotherapy) can help control extensive stage small cell lung cancer for a longer period. The goal is to see if lamivudine can reduce the cancer…

This study is testing whether adding a new immune-stimulating drug (CDX-1140) to two existing cancer drugs works better for women whose ovarian cancer has returned. About 80 participants will receive either the standard two-drug combination or the new three-drug combination, give…

This study is testing if adding propranolol, a common blood pressure and anxiety medication, makes standard chemotherapy and immunotherapy more effective for people with advanced cancer where the esophagus meets the stomach. The idea is that stress hormones might weaken the immun…

This early-stage trial is testing the safety and best dose of a new cell therapy called CD83 CAR T for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatments. Doctors will collect a patient's own immune cells, genetically modify them to ta…

This study is testing a new support program called MedSupport, designed to help parents and caregivers give their children with acute lymphoblastic leukemia (ALL) the correct doses of oral chemotherapy at home. Researchers want to see if this program helps families overcome commo…

This study is testing whether adding a new drug called pegcetacoplan to a standard chemotherapy regimen (mFOLFIRINOX) is safe and effective for people with metastatic pancreatic cancer. Pegcetacoplan aims to help the immune system fight the cancer and may also reduce the risk of …

This study is testing whether a gentle vibration therapy can help blood cancer patients who are undergoing transplants or cellular therapies. The therapy involves standing on a vibrating board for 10 minutes daily, which researchers hope will strengthen bones and potentially boos…

This study is testing a specific combination of four chemotherapy drugs given to patients before surgery for a type of pancreatic cancer that is difficult to remove. The goal is to see if shrinking the tumor first makes surgery more successful and lowers the chance of the cancer …

This study is testing a program called CareMeds that teaches parenting skills to help children with leukemia take their oral chemotherapy at home. It involves 100 parents of children aged 3-9 who are being treated for acute lymphoblastic leukemia (ALL). The goal is to see if this…

This study is testing a two-part treatment for breast cancer that has spread to the brain. Patients receive a personalized vaccine made from their own immune cells, combined with an immunotherapy drug called pembrolizumab. The goal is to see if this combination can shrink brain t…

This large, late-stage trial is testing whether immediately using aggressive treatments like radiation to destroy all visible cancer spread sites helps people live longer than waiting six months. It's for adults with lung, prostate, or colorectal cancer that has spread to 10 or f…

This study is testing whether adding a new drug called GT103 to an existing immunotherapy (pembrolizumab) can better control advanced lung cancer that has a specific genetic change (STK11 mutation). The trial is for patients whose cancer has continued to grow despite prior treatm…

This study is testing whether a patient navigation program can help reduce disparities in breast cancer care. The program helps newly diagnosed women understand their treatment options, connect with support services, and overcome barriers to getting care. Researchers want to see …

This study is testing whether adding propranolol, a common blood pressure medication, to standard chemoradiation treatment helps people with esophageal adenocarcinoma. Researchers want to see if this combination is safe and more effective at controlling the cancer. The trial will…

This study is testing a new, minimally invasive way to deliver chemotherapy directly to the lungs. It aims to kill any tiny, leftover cancer cells after surgery in patients whose sarcoma or colorectal cancer has spread to the lungs. The goal is to prevent the cancer from coming b…

This study is testing whether adding an experimental cancer vaccine to standard chemotherapy works better than chemotherapy alone for advanced neuroendocrine tumors that have spread and are growing. The vaccine aims to train the immune system to attack cancer cells. Researchers w…

This study is testing whether combining two existing drugs—tamoxifen and a special form of doxorubicin—can help control advanced triple-negative breast cancer that has spread or cannot be removed by surgery. It is for patients whose cancer has continued to grow despite at least t…

This study is testing whether a personalized exercise program, guided by a Fitbit, helps patients with ovarian or endometrial cancer meet the recommended 150 minutes of weekly activity better than standard advice. It aims to see if more exercise improves quality of life, physical…

This early-stage study aims to find the safest and most effective dose of a new two-drug combination for people with advanced colorectal or gastroesophageal (stomach/esophagus) cancers that have spread. The trial will enroll about 45 adults whose cancer has progressed after at le…

This study tests a two-step treatment for patients with advanced cancer tumors that block the main breathing tubes in the lungs and cannot be removed by surgery. First, patients receive standard low-dose radiation to shrink the tumor. Then, they receive a special light-sensitive …

This early-stage study is testing a counterintuitive approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking treatments. Researchers are giving patients cycles of testosterone injections to see if rapidly switching between very low …

This study is testing a combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—to see if it can control multiple myeloma that has come back or stopped responding to other treatments and has spread to form tumors in soft tissues or organs. It will involve about 28 …

This study is testing a new combination of two drugs, nemtabrutinib and pembrolizumab, for patients with Richter transformation, a fast-growing type of lymphoma. The goal is to see if using these drugs together is safe and can shrink or control the cancer. The trial will enroll a…

This study is testing a new imaging method called photoacoustic tomography. It combines light and sound waves to create pictures of breast tissue, with the goal of getting clearer images, especially for people with dense breasts. The study is enrolling 400 women, including those …

This study is testing a new, non-invasive imaging device called LC-OCT. It is being used on patients with a common type of skin cancer (basal cell carcinoma) who are scheduled for a precise removal surgery called Mohs. The goal is to see if this scanner can help the surgeon bette…

This study is testing a healthy eating program designed to prevent early-stage bladder cancer from coming back or getting worse. Researchers want to see if eating more vegetables like broccoli, cabbage, and kale can help. The program is being tested on 344 adults in New York who …

This study is testing whether a special breathing exercise program before lung cancer surgery can help prevent serious lung problems like pneumonia after the operation. It involves 220 patients with early to mid-stage lung cancer. Half will do breathing muscle training with a dev…

This study is testing whether a 12-week supervised exercise and nutrition education program, held in a community setting, is practical and helpful for people who have finished cancer treatment. Researchers want to see if this program can improve survivors' confidence, physical fi…

This study is testing whether personalized nutrition advice and a home exercise program can help prostate cancer survivors who are experiencing frailty and weight gain as a side effect of their hormone therapy. Researchers will work with 50 participants for 6 months to see if the…

This study is testing whether virtual reality (VR) relaxation programs can help reduce pain in people with cancer. Researchers will use a special, non-invasive brain scanner to measure pain levels objectively. The goal is to understand how VR distracts the brain from pain and whe…

This study is testing if adding the drug olanzapine to standard care helps head and neck cancer patients keep their appetite and weight during difficult chemoradiation treatment. About 66 patients will be randomly assigned to receive either standard care alone or standard care pl…

This study is testing a free support program designed to help breast cancer survivors in Western New York transition to life after their main cancer treatments are finished. The program combines group support sessions with one-on-one mentoring from a long-term survivor. Researche…

This study is testing whether a 12-week program of breathing exercises done at home can help reduce side effects for people undergoing chemotherapy for breast cancer. The exercises aim to strengthen breathing muscles and may help lessen heart and lung strain, fatigue, and stress …

This study is testing whether a home-based breathing exercise program can help people who have had early-stage lung cancer. Many survivors experience shortness of breath and fatigue after treatment, which makes it hard to stay active. Researchers want to see if strengthening brea…

This study is testing whether a new financial support program called 'Financial Compass' can help head and neck cancer patients who are struggling with money problems. Researchers want to see if this program works better than usual care at identifying and addressing financial har…

This study is testing whether a 12-week virtual exercise program, delivered through a partnership with the YMCA, is practical and helpful for underserved cancer survivors. The main goal is to see if this community-based approach is feasible and if it improves participants' qualit…

This study is testing whether using a special headset that delivers a mild electrical current to the earlobes, combined with group life coaching sessions, can help reduce feelings of burnout and moral distress in oncology healthcare workers. About 40 eligible workers will use the…

This study is testing whether non-drug approaches like exercise, intermittent fasting, and adding a common blood pressure medication (propranolol) to standard treatment can improve the immune system and quality of life for people with multiple myeloma or related blood disorders. …

This study is testing an education and navigation support tool designed to help patients with advanced bladder cancer and their caregivers participate more actively in treatment decisions and care planning. The program provides educational resources, connects patients to support …

This study aims to understand how different risk warning labels on smokeless tobacco products affect people's sensory experience and future interest in using them. Researchers will recruit 50 adult daily smokers from Western New York to try tobacco products with various warning m…

This study aims to understand why and how young adults start and continue using both tobacco and cannabis together. Researchers will interview 40 people aged 18-30 who use cannabis weekly and either smoke cigarettes or vape nicotine daily. The goal is to learn about the personal,…

This study aims to understand if adult smokers can still detect menthol flavor in cigarettes sold in different states after flavor restrictions. Researchers will recruit 30 daily menthol cigarette smokers in New York to smell and taste various cigarette products. The goal is to g…

This study aims to understand how young people who have survived sarcoma experience chronic pain and use opioid medications. Researchers will ask 40 participants to complete brief daily surveys on their smartphones for three months to track their pain levels, opioid use, and rela…

This study aims to measure the levels of nicotine, cannabis, and potentially harmful chemicals in the bodies of young adults who use e-cigarettes, cannabis, or both. Researchers will recruit 150 participants aged 18-25 to provide blood and urine samples and complete surveys about…

This study aims to understand how daily smokers react to new health claims on smokeless tobacco products like Copenhagen and General Snus. Researchers will show 160 smokers from Western New York advertisements with these claims and measure their interest in buying the products an…

This study aims to see if providing patients with quality-of-life information helps them make better decisions about their early-stage lung cancer treatment. It compares two groups: one receives a fact sheet about life after surgery or radiation, and the other receives standard c…

This study is testing a community workshop designed to teach people how to organize local actions to help reduce the impact of cancer in their area. Researchers want to see if the workshop is practical, well-received, and what kinds of plans participants create. The goal is to em…

This study follows 700 patients with advanced breast cancer who are taking specific cancer drugs called CDK4/6 inhibitors. Researchers will collect blood and tissue samples to understand why some patients respond well to treatment while others develop resistance. The goal is to l…