Roswell Park Cancer Institute

This study tests whether adding propranolol (a beta-blocker used for heart conditions) to standard chemotherapy and immunotherapy (pembrolizumab) can improve treatment for advanced esophageal or gastroesophageal junction cancer that cannot be surgically removed. About 40 adults w…

This study tests whether adding a cancer vaccine (SurVaxM) to standard chemotherapy (temozolomide) helps control advanced neuroendocrine tumors that are growing. About 60 adults with metastatic disease will receive either the combination or chemo alone. The goal is to see if the …

This study tests a program called CareMeds that teaches parents behavioral skills to help their young children (ages 3-9) with acute lymphoblastic leukemia take oral chemotherapy at home. Researchers will enroll 100 families across two cities to see if the program is acceptable a…

This study tests a healthy eating program that encourages people with early-stage bladder cancer to eat more cruciferous vegetables like broccoli, kale, and cabbage. These veggies contain natural compounds that may help keep cancer from returning or getting worse. The program inv…

This study tests whether adding an experimental drug (APL-2) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) works better than bevacizumab alone for recurrent ovarian, fallopian tube, or peritoneal cancer that causes fluid buildup. About 60 adults w…

This study tests whether adding an experimental drug (CDX-1140) to a standard immunotherapy combo (pembrolizumab and bevacizumab) can shrink tumors in people with ovarian cancer that has returned. About 80 adults with recurrent ovarian, fallopian tube, or peritoneal cancer will r…

This early-phase trial tests whether adding an experimental drug called SX-682 to standard cancer drugs is safe for people with multiple myeloma that has come back or not responded to prior therapy. SX-682 works by blocking signals that suppress the immune system, potentially hel…

This study tests a procedure called pulmonary suffusion, which delivers chemotherapy drugs like cisplatin directly to the lungs through a minimally invasive method. The goal is to control any remaining cancer cells after surgery or ablation in patients with sarcoma or colorectal …

This study tests a new drug combination (GT103 plus pembrolizumab) for people with advanced non-small cell lung cancer that has a specific genetic change called STK11 mutation. The goal is to see if adding GT103 can help shrink tumors or slow the cancer's growth. About 28 adults …

This early-phase study tests a combination of two drugs—trifluridine/tipiracil (a chemotherapy) and talazoparib (a targeted therapy)—in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side eff…

This study looks at whether treating small numbers of cancer spread (1 to 10 spots) right away helps people live longer compared to waiting six months. It includes adults with lung, colorectal, or prostate cancer that has newly spread. The goal is to see if immediate treatment im…

This study tests a new drug called pegcetacoplan combined with standard chemotherapy (mFOLFIRINOX) in people with pancreatic cancer that has spread to other parts of the body. The goal is to see if the combination is safe and helps control the cancer better, while also reducing d…

This study tests whether doing special breathing exercises before lung cancer surgery can lower the chance of problems like pneumonia or breathing trouble after the operation. About 220 people with stage I-IIIB lung cancer will either do the training or receive usual care. The go…

This early-phase trial tests a new treatment for adults with acute myeloid leukemia (AML) that has returned or not responded to standard therapy. The treatment uses specially engineered immune cells (CD83 CAR T cells) designed to find and destroy leukemia cells while possibly avo…

This early-phase study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy and has spread. The approach rapidly switches testosterone levels from very low to very high to shock cancer cells an…

This study tests a combination of two treatments for people with breast cancer that has spread to the brain. One is a vaccine made from the patient's own immune cells, designed to help the body recognize and attack cancer. The other is a drug called pembrolizumab, which helps the…

This study tests a chemotherapy combination called NALIRIFOX given before surgery to people with a type of pancreatic cancer that is close to major blood vessels but may still be removable. The goal is to shrink the tumor enough to make surgery more successful and lower the chanc…

This study tests whether adding tamoxifen to a standard chemotherapy drug (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. About 30 adults who have already tried at least two other tre…

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This study tests whether adding the blood pressure drug propranolol to standard chemoradiation is safe and effective for people with esophageal adenocarcinoma. About 106 participants will receive the combination, and researchers will monitor side effects and how long the cancer s…

This study tests a two-step treatment for people with advanced cancer that blocks their main breathing passages. First, they get low-dose radiation to shrink the tumor. Then, they receive a light-sensitive drug and a laser treatment to destroy remaining tumor tissue. The goal is …

This study tests a two-step approach for people with advanced or returning colorectal cancer. First, a special drug makes cancer cells glow during surgery, helping surgeons remove more of them. Then, a laser activates the drug to kill any remaining cancer cells. The goal is to im…

This study tests whether adding lamivudine, an antiviral drug, to standard chemotherapy and immunotherapy can stop small cell lung cancer from becoming resistant to treatment. About 28 adults with extensive-stage small cell lung cancer will receive the combination. The goal is to…

This study tests two drugs together for people with Richter transformation, a fast-growing lymphoma that can arise from chronic lymphocytic leukemia. The drugs aim to block cancer growth and help the immune system attack the cancer. About 32 adults who have not responded to or ca…

This study is testing a three-drug combination (MeziKD) for adults with multiple myeloma that has come back or stopped responding to other treatments and has spread to form tumors in soft tissues or organs. The goal is to see if this combination can shrink these tumors and contro…

This study tests a new, non-invasive imaging device called LC-OCT that takes detailed pictures of skin cancer before surgery. The goal is to see if it can help doctors better identify where the cancer ends, so they can remove it all in one go. About 60 adults with a common type o…

This study tests a new imaging technique called photoacoustic tomography, which uses light and sound to see breast tissue more clearly. It includes women with suspicious or confirmed breast cancer and healthy volunteers. The goal is to find better ways to detect breast cancer, es…

This study tests whether using virtual reality (VR) can improve symptoms like pain, anxiety, and fatigue in patients receiving a bone marrow transplant. About 28 adult patients will either use VR or receive standard care while in the hospital. The goal is to see if VR helps them …

This study tests a community-based exercise program for cancer survivors who have finished active treatment. Researchers partner with the YMCA to offer tailored home workouts. The goal is to see if this program is practical and helps improve quality of life. About 200 participant…

This study looks at whether a low-intensity vibration board can help blood cancer patients who are planning to have a stem cell transplant or immune cell therapy. The vibrations may strengthen bones and improve muscle function, and might also boost the body's immune cells. Resear…

This study tests whether a home-based breathing exercise program can help lung cancer survivors (stages I-III) who often struggle with shortness of breath, fatigue, and low fitness after surgery. About 100 participants will do breathing exercises regularly for several weeks. Rese…

This study tests whether a 12-week community-based exercise and nutrition program is practical and helpful for cancer survivors. Researchers want to see if it improves survivors' confidence, physical fitness, and quality of life. About 150 cancer survivors or their caregivers wil…

This study tests whether a small device that sends a gentle electrical current through the earlobes, combined with life coaching sessions, can reduce burnout and moral distress in healthcare workers who treat cancer patients. About 40 doctors, nurses, and other staff who feel emo…

This study tests a program called MedSupport that helps families of children with acute lymphoblastic leukemia give their daily chemotherapy at home. Missing even a few doses can raise the risk of cancer coming back. The program works with hospitals, doctors, and parents to find …

This study looks at whether adding olanzapine to usual care can help prevent severe appetite loss and weight loss in people with head and neck cancer who are getting chemoradiation. About 66 adults will take part. The goal is to see if this approach helps patients maintain their …

This study tests whether a single, highly targeted dose of radiation (SBRT) works better than standard radiation for relieving pain and improving quality of life in people whose cancer has spread. About 1,500 participants with metastatic cancer will be randomly assigned to one of…

This study looks at whether non-chemo approaches like physical activity, intermittent fasting, or adding a beta-blocker (propranolol) can improve immune function and quality of life in people with multiple myeloma or related blood disorders. About 175 adults with smoldering or ac…

This study tests whether easy, at-home breathing exercises can help reduce heart and lung side effects in people undergoing chemotherapy for breast cancer. About 130 adults will do these exercises regularly during their treatment. The goal is to see if this approach is practical …

This study tests whether a personalized activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get standard care or the automated program. Researchers will also…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors (ciclibs). Researchers collect blood, tissue, and fluid samples to understand how the cancer responds and why resistance develops. The goal is to improve treatment decisions a…

This study looks at how daily smokers in Western New York react to advertisements that claim certain smokeless tobacco products are less harmful than cigarettes. Participants will watch ads and share their opinions, including whether they'd consider buying the product. The goal i…

This study looks at how much nicotine, cannabis, and harmful chemicals are in the blood and urine of young adults (ages 18-25) who use e-cigarettes, cannabis, or both. Researchers want to compare the levels of these substances across different user groups and understand their usa…

This study is testing a patient navigation program for 126 newly diagnosed breast cancer patients. The program helps patients understand their care options, connect with support services, and overcome barriers to treatment. The goal is to see if this approach can improve health e…

This study asks 30 daily menthol smokers to smell and taste cigarettes sold in New York and California to see if they can detect menthol flavor. California banned menthol cigarettes in 2022, but some brands may still taste minty. The goal is to understand if removing menthol as a…

This study looks at how messages about smokeless tobacco risks change the way people experience using these products and whether they plan to use them again. About 50 adult smokers from Western New York who are open to trying smokeless tobacco will take part. Researchers will mea…

This study tests a community workshop called I CAN that teaches people how to work together to reduce cancer in their area. About 200 healthy adults in Western New York will take part. The goal is to see if the program is practical and well-liked, not to directly treat or prevent…

This study tests a support program for breast cancer survivors in Western New York. The program includes group sessions and one-on-one mentoring with a long-term survivor. It aims to help women, especially Black women, transition into life after treatment by connecting them with …

This study tests a new program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients who are struggling financially will either get the program or usual care. The goal is to see if the program is prac…

This study interviews 40 adults aged 18-30 who use both cannabis and either cigarettes or nicotine vapes. Researchers want to learn how and why people start, increase, and keep using these substances together. The goal is to better understand the social and personal factors behin…

This study is testing whether a special education and navigation support tool helps patients with advanced bladder cancer and their caregivers feel more involved in treatment decisions. The tool provides information and guidance to improve care coordination. Researchers will meas…

This study collects blood and tumor tissue from 100 people with pancreatic cancer who are about to receive standard chemotherapy. Researchers will use artificial intelligence to look for biomarkers that might predict which treatment works best for each person. The goal is to make…

This study looks at whether giving early-stage lung cancer patients information about quality of life helps them choose between surgery and radiation therapy. About 150 adults with stage I-II lung cancer who can have either treatment will take part. The goal is to see if this inf…

This study aims to see if a 3-month daily survey method is practical for understanding chronic pain and opioid use in adolescent and young adult sarcoma survivors. About 40 participants aged 12-24 at diagnosis, now in survivorship care with meaningful pain, will complete brief da…