Roswell Park Cancer Institute

This study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted pills (sotorasib or adagrasib) can help people with advanced KRAS G12C-mutated lung cancer live longer without their disease getting worse. About 29 adults with stage III or IV non-small cell lung…

This study tests a new combination treatment for people with advanced non-small cell lung cancer that has not responded to standard therapies. The treatment uses a light-activated drug (ASP-1929) plus an immunotherapy drug (cemiplimab) to target and kill cancer cells. About 27 ad…

This early-stage trial tests a new treatment called GB-5267, which uses a patient's own immune cells (T cells) that are modified to better find and attack ovarian cancer cells. The study includes 18 adults with platinum-resistant ovarian cancer, meaning their cancer did not respo…

This study looks at whether a new type of ultrasound, called transperineal micro-ultrasound, can find prostate cancer during a biopsy. Instead of the usual probe placed in the rectum, this one is placed on the skin between the scrotum and anus. It uses higher sound wave frequenci…

This study tests if home-based breathing exercises and stationary biking can improve lung health in 200 current or former smokers aged 50 and older. Participants will use a handheld breathing device or a stationary bike for 12 weeks. The goal is to see if these exercises are prac…

This study tests whether a low dose of psilocybin (a compound from magic mushrooms) combined with talk therapy is safe and helpful for easing chronic cancer pain in 20 adults who already take opioids. Participants will receive psilocybin in a supervised setting and undergo counse…

This study looks at how vaping THC liquids compares to smoking cannabis in healthy adults who use both. Researchers will measure THC levels in the blood and any side effects. The goal is to understand the differences in how these products deliver THC and their short-term safety.

This study looks at how using nicotine vapes before or after THC affects how much THC gets into your blood. Researchers will test 60 adults who already use both THC and nicotine vapes. The goal is to understand safety and how these products compare to smoking cannabis.