Roswell Park Cancer Institute

This study is testing whether combining a cancer vaccine (CIMAvax) with immunotherapy drugs (nivolumab or pembrolizumab) is safe and effective for people with advanced non-small cell lung cancer or squamous head and neck cancer. The goal is to help the body's immune system better…

This program provided continued access to an experimental vaccine called SurVaxM for patients with glioblastoma, a serious brain cancer. It was for patients who had no other comparable treatment options or who had already completed a prior SurVaxM trial and wished to keep receivi…

This early-phase study is testing whether adding an experimental vaccine called CIMAvax-EGF to standard colorectal cancer treatments can help the patient's immune system fight the cancer. It will enroll a small number of people with advanced colorectal cancer that has spread and …

This study is testing if giving testosterone replacement therapy (TRT) to men with low testosterone and early-stage prostate cancer is safe and improves their quality of life. The men are on 'active surveillance,' which means their cancer is being closely monitored instead of bei…

This study is testing a two-step approach during surgery for advanced or returning colorectal cancer. First, patients take a pill that makes cancer cells glow under a special blue light, helping surgeons see and remove more tumor tissue. Then, surgeons use a red laser light to tr…

This early-stage study is testing a new combination of drugs for patients with an aggressive type of lymphoma (DLBCL) that has returned or not responded to previous treatment. Researchers are adding a drug called carfilzomib to a standard chemotherapy regimen to see if it's safe,…

This study tests whether adding a targeted drug called belantamab mafodotin to standard lenalidomide treatment can eliminate tiny amounts of remaining cancer cells in multiple myeloma patients who have had a stem cell transplant. The goal is to help patients achieve and maintain …

This early-stage study is testing a new treatment for advanced liver cancer that has come back or stopped responding to standard therapies. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer cells, and then infuse them back into …

This study is testing a new, faster way to give radiation after surgery for non-small cell lung cancer. Instead of weeks of daily treatments, doctors give one powerful, highly focused dose to try to kill any leftover cancer cells while aiming to spare healthy lung tissue. The mai…

This study is testing a combination of two drugs, pazopanib and bevacizumab, for people with advanced kidney cancer that has spread. The main goals are to find the safest and most effective dose and to see how well the treatment works to control the cancer and stop it from gettin…

This small, early-stage study is testing the safety of a two-step treatment for early-stage non-small cell lung cancer. First, patients receive a single, highly focused dose of radiation to their tumor. Then, about a month later, they have surgery to remove it. The goal is to see…

This study is testing whether adding an experimental vaccine called SurVaxM to standard chemotherapy (temozolomide) can help control a serious brain cancer called glioblastoma. The vaccine is designed to teach the body's immune system to recognize and attack cancer cells. The tri…

This study is testing whether a non-invasive brain stimulation technique called rTMS can help smokers quit and prevent them from starting again. Researchers are comparing different doses and schedules of the treatment to find what works best. The study includes smokers who want t…

This study is testing how well a chemotherapy drug called CPX-351 works for adults under 60 with secondary acute myeloid leukemia, a type of blood cancer that develops from other blood disorders or previous cancer treatments. The goal is to see if this drug can help patients achi…

This study is testing a program called PC TEACH, which helps rural primary care clinics use proven strategies to increase HPV vaccination among adolescents. The goal is to prevent future cancers caused by the human papillomavirus. The program works with clinics over 12 months to …

This study is testing whether delivering half-price boxes of fresh produce, with or without extra nutrition education, can help low-income families eat healthier and become more food secure. The goal is to see if better access to nutritious food can help prevent obesity-related c…

This study is testing a culturally-appropriate education program designed to help Native American men reduce their consumption of sugary drinks like soda and juice. The program involves group classes and text message support over six months. The goal is to see if this approach ca…

This study is testing if more frequent, detailed symptom surveys can help patients with head and neck cancer feel better during and after radiation therapy. Researchers are comparing a group that fills out surveys twice a week to a group that receives standard weekly check-ins. T…

This study is testing whether a mental exercise called 'episodic future thinking' can help people smoke fewer cigarettes. Participants are asked to vividly imagine positive events they look forward to happening in the next year. Researchers will measure changes in smoking by chec…