Roswell Park Cancer Institute

This early-phase trial tests a vaccine (SVN53-67/M57-KLH) designed to help the immune system recognize and attack multiple myeloma cells. It is given alongside a standard maintenance drug (lenalidomide) to 18 patients who have already responded to initial treatment. The main goal…

This study tests a program called PC TEACH that helps rural doctor's offices give more HPV vaccines to teens. HPV vaccines can prevent several cancers, but many rural teens miss out. The program coaches clinics on better ways to talk about and offer the vaccine. Researchers will …

This study tests a vaccine called SurVaxM, given with standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to see if adding the vaccine helps ke…

This study tested two drugs, pazopanib and bevacizumab, given in turns to people with advanced kidney cancer that had spread. The goal was to find the best dose and see if the combination could control tumor growth. 51 patients took part, and the study focused on safety and how l…

This study tests a vaccine called CIMAvax combined with immunotherapy drugs (nivolumab or pembrolizumab) in people with advanced non-small cell lung cancer or head/neck cancer that has spread. The goal is to find the best dose and see if the combination helps control tumor growth…

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers who are…

This early-stage trial tests a new treatment for ovarian, fallopian tube, or peritoneal cancer that has returned or not responded to standard therapy. Patients receive their own T cells that have been genetically modified to recognize and attack cancer cells, along with a drug ca…

This study compares giving the immunotherapy drug pembrolizumab every 12 weeks versus every 3 weeks for people with non-small cell lung cancer who are already benefiting from the drug. The goal is to see if the less frequent schedule works just as well, which could mean fewer hos…

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other bone marrow diseases or cancer treatments. The goal is to see how many patients achieve complete remission. 21 particip…

This early-phase study was designed to test the safety and best dose of an experimental oral drug called GB1211 (selvigaltin) when added to standard therapy for multiple myeloma that has returned or stopped responding. The drug targets a protein linked to inflammation and cancer …

This program gives certain glioblastoma patients at Roswell Park access to SurVaxM, a treatment that may help slow tumor growth and extend survival. It is for patients who have no other treatment options or who have already benefited from SurVaxM in a prior study. The goal is to …

This study looks at how well a non-invasive brain stimulation technique called rTMS can help people stop smoking and avoid relapsing. Researchers are testing different doses to find the most effective one. The study involves 206 current smokers who want to quit within the next 30…

This early-stage trial tests a new treatment for people with advanced liver cancer that has not responded to standard therapies. The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells carrying a specific protein called GPC3. The …

This study tests whether giving a combination of drugs (enteric-coated aspirin, rintatolimod, and possibly interferon-alpha 2b) before prostate cancer surgery can help the immune system fight the tumor more effectively. About 12 men with early-stage prostate cancer who are schedu…

This study tested a new combination of drugs (carfilzomib plus standard chemotherapy) in 29 adults with diffuse large B-cell lymphoma that returned or didn't respond to prior treatment. The goal was to find the best dose and see how well it shrinks tumors. The approach aims to im…

This study tests a combination of two drugs—belantamab mafodotin and lenalidomide—in people with multiple myeloma who still have traces of cancer after a stem cell transplant. The goal is to see if the treatment can make those traces disappear and keep the cancer from coming back…

This very early study tests a vaccine (CIMAvax-EGF) given with standard treatments for metastatic colorectal cancer that has certain gene types. The goal is to see if the vaccine can trigger the immune system to fight the cancer. Only 2 people are enrolled, so results are very li…

This study tests whether a single, powerful dose of targeted radiation (SBRT) is as safe and works as well as the usual multiple doses for people with central non-small cell lung cancer. About 30 adults with early-stage tumors near the chest center will receive one treatment and …

This study tests a culturally-appropriate education program called Indigenous SIPin for Native American men who are part of athletic communities. The goal is to help them drink fewer sugary beverages like soda and juice, which can lead to obesity, diabetes, heart disease, and som…

This study looks at whether giving a single, precise dose of radiation after lung cancer surgery is safe and causes fewer side effects than the usual weeks-long radiation. About 50 adults with non-small cell lung cancer who had surgery but still have cancer cells at the edge of t…

This study tests a technique called episodic future thinking (EFT) to help smokers cut down. Participants imagine positive events they look forward to in the next year, while a control group recalls happy past events. The goal is to see if focusing on the future reduces cigarette…

This study tests whether using a machine learning program to closely monitor symptoms can help head and neck cancer patients avoid urgent hospital visits during radiation therapy. About 72 adults with non-spreading head and neck cancer will either receive standard care or extra s…

This study looks at whether delivering fresh produce, with or without nutrition education, can improve diet and reduce food insecurity in low-income families in Western New York. About 50 adults who handle most of their household's food shopping and have limited food access will …