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New drug combo aims to tame stem cell Transplant's worst side effect

NCT ID NCT03192397

First seen Apr 20, 2026 · Last updated Jun 07, 2026 · Updated 10 times

Summary

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers or severe aplastic anemia who are getting a transplant from a matched donor. Participants receive chemotherapy and radiation before the transplant, then cyclophosphamide afterward to help prevent GVHD.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

Conditions

The condition(s) this trial relates to.

acute myeloid leukemia aplastic anemia graft versus host disease Hodgkins lymphoma Leukemia, Myelogenous, Chronic, BCR-ABL Positive Myelodysplastic Syndromes Myeloproliferative Disorders Neoplasm, Residual non-Hodgkin lymphoma plasma cell myeloma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.