Nyu Langone Health

This study tests a new combination of drugs to prevent graft-versus-host disease (GVHD) in 27 adults receiving a stem cell transplant from a half-matched donor. The goal is to see if using lower doses of certain immune-suppressing drugs can still prevent GVHD while causing fewer …

This study tests a program where HIV nurses are trained to also manage high blood pressure in their patients. About 830 adults with HIV and uncontrolled high blood pressure from 30 clinics in Lagos, Nigeria will take part. The goal is to see if this approach helps lower blood pre…

This study tests a program to help Black patients with high blood pressure get it under control. It combines nurse support, home blood pressure monitoring, and help with social needs like housing or food. About 500 patients from 25 clinics in New York City will take part. The goa…

This study tests whether a personalized program—including patient outreach, health education, and financial help—can lower the risk of dying from preventable causes like heart disease, heavy drinking, and HIV. About 87 low-income adults aged 35 to 64 are taking part. The program …

This study tests a drug called Lutathera, which delivers radiation directly to meningioma tumor cells. It involves 32 adults with progressive or high-risk meningioma who receive four doses over 8 weeks. The main goal is to see if the treatment can stop tumor growth for at least 6…

This pilot study tests two approaches to help people living with HIV/AIDS in South Africa reduce their cigarette smoking: using e-cigarettes or nicotine replacement therapy (like patches). Both groups also receive supportive text messages. The goal is to see which method is more …

This study looks at how to help people with opioid use disorder stay in treatment longer and, if appropriate, stop their medication without relapsing. Over 1,500 adults chose either buprenorphine or naltrexone and were assigned different treatment plans. The goal is to find which…

This phase 2 trial tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe immune-related side effects in people with advanced melanoma that cannot be removed by surgery. About 71 participants will receive the three drugs during an …

This study tests whether a telehealth coaching program led by community health workers can help South Asian patients better control their diabetes and high blood pressure. About 450 adults with both conditions will either receive the coaching or usual care. The main goal is to se…

This study tests if a shorter course of radiation (3 sessions over 5 days) is as safe and effective as the standard 5-session course for women with early-stage breast cancer. The trial involves 284 post-menopausal women who have had surgery to remove their tumor. The main goal is…

This study tests whether keeping people with opioid use disorder in the emergency department for a longer observation period helps them start medication (like buprenorphine) and connect to follow-up care. About 170 adults from four hospitals will be randomly assigned to standard …

This study looks at whether offering alcohol treatment in Black churches helps more people start and stick with treatment compared to traditional clinics. About 137 Black adults with alcohol use disorder will receive therapy either in a church or a clinic. The goal is to see whic…

This study looks at whether a special diet, exercise, and lifestyle program (called LIFE) can help stop uterine fibroids from coming back after they have been surgically removed. About 100 women aged 18-50 who are currently fibroid-free after surgery will try the program for seve…

This study tests a new, precise radiation technique for people whose cancer has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). The goal is to see if this approach can delay cancer growth in the central nervous system better than standard radiation.…

This study looks at whether giving a blood transfusion to adults whose heart has stopped for at least 10 minutes can improve oxygen flow to the brain and other vital organs during CPR. The goal is to see if this approach is feasible and safe, and whether it helps more people surv…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with muscle-invasive bladder cancer keep their bladder. About 60 participants who cannot or choose not to have bladder removal surgery will receive this com…

This study tests whether a collaborative care model—where primary care doctors work with a care team—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy alcohol. About 300 participants will receive this team-based support. The goal is to see …

This study uses advanced PET and MRI brain scans to look for signs of inflammation and blood vessel problems in people with long COVID who have brain-related symptoms like memory issues, anxiety, or depression. Researchers will compare 30 participants with these symptoms to healt…

This study aims to improve MRI quality for people with irregular heartbeats (arrhythmia). Researchers will test two special imaging methods on 105 patients with arrhythmia and 30 healthy volunteers to see if they produce clearer pictures than standard MRI. The goal is to help doc…

This study looks at the best time to use a special PET scan (rhPSMA-7.3) to find prostate cancer that has come back after the prostate is removed. Men with a rising PSA level will get one or two scans to see where the cancer is hiding. The goal is to catch the cancer early so tre…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps. About 264 women who are already scheduled for a standard breast MRI will take part. If successful, this could…

This study looks at whether helping families switch to cleaner cookstoves can reduce indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will either receive community support to adopt the stoves or just get information on their own. Researchers…

This study tests whether a diabetes prevention program delivered via telehealth works as well as in-person classes for adults 65 and older with prediabetes. About 238 participants will be randomly assigned to either a tailored telehealth program or an in-person group. The goal is…

This study tests whether mailing at-home stool tests (FIT) to people who are due for colorectal cancer screening can increase screening rates in underserved Brooklyn communities. About 3,000 adults aged 45-75 who get care at certain health centers will take part. The goal is to c…

This pilot study tests whether virtual reality treadmill training can improve balance, mobility, and reduce fear of falls in people with traumatic brain injury. Twenty adults aged 18 to 90 who have had a TBI for at least a year will be randomly assigned to either VR treadmill tra…

This study tests whether coaching can help people with dementia and their caregivers after an emergency room visit. About 19,200 participants aged 66 and older will receive different combinations of support to connect them with community services. The goal is to improve care, red…

This study looks at whether cryotherapy (cooling therapy) can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will use cryotherapy during their standard chemo treatment. The goal is to see if this …

This study adapts a proven PTSD treatment (STAIR-NT) for people in methadone programs who also use cocaine and opioids. About 80 participants will either get the adapted therapy or usual care. The goal is to see if the therapy is practical, acceptable, and helps reduce drug use a…

This study was designed to see if adding a hyaluronic acid-based vaginal moisturizer to standard vaginal estrogen therapy provides better relief for menopause-related vaginal symptoms. It planned to include postmenopausal women aged 45 and older who had not used these treatments …

This early-phase study tests the safety of adding the drug azeliragon to radiation therapy for adults whose cancer has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 21 participants with solid tumors or high-grade gliomas will receive the com…

This study tests a medicated film placed under the tongue to quickly calm severe episodes called autonomic crises in people with familial dysautonomia. About 15 participants aged 16 and older will use the film at home during a crisis, while their heart rate, blood pressure, and s…

This study looks at whether special fast-dissolving foods can improve the eating experience for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Rese…

This study tests whether giving magnesium sulfate during prostate surgery helps lower pain and the need for strong painkillers. About 68 adults having robotic prostate surgery will either receive magnesium or not, as part of their standard anesthesia. The goal is to see if magnes…

This study tests a light therapy that shines a special light on the forehead to see if it can help memory and thinking in people with early Alzheimer's or mild cognitive impairment. About 196 older adults (ages 65-85) will receive either the real light treatment or a fake one for…

This study tested whether a vibrating device could reduce pain during platelet-rich plasma (PRP) scalp treatments for hair loss. About 100 people who had already had at least one PRP treatment would have half their scalp treated with the device and the other half without, then ra…

This study explores whether a short, phone-delivered mindfulness program can help people who are very worried about pain before spine surgery. About 25 adults will take part in weekly sessions before their operation and be followed for two weeks after. The goal is to see if this …

This study tests whether reconnecting nerves during implant-based breast reconstruction helps restore nipple sensation. Six women having both breasts reconstructed will receive the nerve procedure on one breast only, so each woman acts as her own comparison. The goal is to see if…

This small pilot study tests whether a dissolvable film placed under the tongue can safely treat sudden, severe episodes (autonomic crises) in people with familial dysautonomia at home. Five adults who have had these episodes before will use the film and be monitored. The main go…

This early-phase study tests whether a mobile app that shares continuous glucose monitor data with a care partner can help older adults (65+) with type 2 diabetes and mild cognitive impairment manage their blood sugar. Fourteen participants and their care partners will use the ap…

This study compares a newer, muscle-sparing surgical approach for total shoulder replacement to the traditional method in 108 adults with arthritis. The goal is to see if the newer technique leads to better shoulder function and tendon health after surgery. Participants are rando…

This study tests whether a stellate ganglion block—an injection of numbing medicine near nerves in the neck—can reduce PTSD symptoms and related brain activity. About 79 adults with chronic PTSD will receive either the real injection or a placebo (saline). Researchers will measur…

This study tests whether giving ketamine during or after breast surgery can lower the chance of long-term pain. About 765 women having mastectomy will get a low-dose ketamine infusion or a placebo (salt water). The goal is to see if ketamine helps reduce pain severity and interfe…

This small pilot study tests whether a non-invasive technique called low-intensity focused ultrasound (LIFU) can safely target a deep brain area (the thalamus) in people with treatment-resistant schizophrenia. Only 3 participants were planned, and the main goal was to see if the …

This study tests whether taking creatine supplements can improve voice quality in people over 65 who have age-related voice changes (presbyphonia). Twenty participants will be randomly assigned to receive either creatine or a placebo for 10 weeks. Researchers will measure voice f…

This study explores whether playing a low-frequency sound (1 Hz) during deep sleep can reduce seizure activity in people with epilepsy. Thirty-six adults will use a smartphone app and special headphones at home for two months. The goal is to see if this simple, non-invasive appro…

This study looks at why some women with heart disease symptoms have clear major arteries but still have chest pain or stress test issues. Researchers think tiny heart vessels or blood clotting problems may be the cause. About 206 women will have extra tests during their heart cat…

This study follows about 15,000 children and young adults (ages 0-25) to learn more about long COVID, also called PASC. Researchers will track symptoms, risk factors, and health outcomes in those who had COVID-19 and those who did not. The goal is to better understand how the vir…

This study looks at 15 people who had a heart attack even though their arteries were not blocked. Researchers use special cameras to see inside the heart and arteries to find out what caused the attack. The goal is to learn more about this puzzling condition, not to test a new tr…

This study tests a new device called Napoleon that helps doctors measure the size of the stomach connection (anastomosis) in people who had gastric bypass surgery and later regained weight. About 100 patients will have their stomach connection measured both by the doctor's eye an…

This study looks at whether a 15-week program of device-guided breathing can improve heart rate variability and quality of life in people with takotsubo syndrome, also known as broken heart syndrome. Ten people with a history of the condition and ten healthy volunteers will have …

This study looks at whether sending cardiologists quarterly emails about their prescribing habits can help more patients get the right medications for heart failure and atrial fibrillation. About 7,000 patients will be included. The goal is to see if this simple feedback strategy…

This study looks at how normal sleep changes and sleep apnea might increase the risk of Alzheimer's disease in healthy older adults. Researchers will monitor sleep and brain changes in 158 people aged 55-75 over two years. The goal is to find ways to prevent Alzheimer's by improv…

This study tests new MRI software to see how the heart and lungs interact during breathing. About 100 adults with heart disease will get extra scans during their regular MRI. The goal is to see if the new method produces clearer images and is practical for daily use.

This study looks at two methods to help pregnant women adopt healthy lifestyles: one uses text messages and online videos, the other uses community health workers for group or individual sessions. Researchers will enroll about 1,050 pregnant women from 10 clinics to see which app…

This study tracks how often family members of ovarian cancer patients with certain gene mutations (like BRCA) get tested themselves. The goal is to see if 'cascade testing' helps find more people at risk, so they can take steps to prevent cancer. About 118 patients and their rela…

This study looks at 200 FDNY rescue workers who were exposed to World Trade Center dust and now have stomach or airway issues. Researchers will test saliva and breath samples to find better, noninvasive ways to detect conditions like acid reflux, Barrett's esophagus, and lung dis…

This study looks at whether wearing a splint and doing formal physical therapy after wrist fracture surgery is necessary. 230 adults with a broken wrist were assigned to either early movement (no splint, self-guided exercises) or late movement (splint, formal therapy). The goal i…

This study watches how the pupil changes size when a nerve in the ear is stimulated during cochlear implant surgery. It involves 30 adults getting a cochlear implant or a vagal nerve stimulator. The goal is to learn more about how this nerve works, not to treat hearing loss direc…

This study looks at 450 people who had a heart attack but no major blockages in their heart arteries. Using advanced imaging, researchers aim to find the real cause, like hidden plaque or tears. Participants are followed every 6 months for up to 10 years to track health outcomes.

This study looks at why some people have a weak response to the standard hepatitis B vaccine. Researchers will compare the standard vaccine with a newer one that works better for many people. The goal is to understand the immune system's response and help design more effective va…

This study was designed to see if adding an internal brace during ACL reconstruction surgery helps the knee heal better. Researchers planned to compare standard surgery with surgery plus internal bracing in people with ACL injuries. However, the study was withdrawn before any par…

This study looks at whether giving extra parenting support to families with very young children in Flint, Michigan can help kids' development and mental health after the water crisis. About 486 families with babies up to 3 months old took part. Researchers measured parenting stre…

This study uses a special MRI technique to measure the amount of saturated fat in breast tissue without needing a biopsy. Researchers want to see if women with breast cancer have higher levels of saturated fat in their breasts compared to women with non-cancerous lumps. About 190…

This study explores whether a type of MRI called diffusion MRI can accurately measure how head and neck tumors change during chemotherapy and radiation. Researchers will scan 16 patients before and during treatment to see if the MRI can predict whether the cancer shrinks or disap…

This study looked at whether a simple behavioral nudge could encourage more people aged 45-75 to complete a take-home colon cancer screening test (FIT). The study was planned at an urban clinic but was withdrawn before enrolling anyone. No results are available.

This study tests a new technique that aims to stimulate the entire cochlea (the hearing organ) using standard-length electrodes, avoiding the risks of longer ones. Researchers will measure how well 40 adults with cochlear implants understand speech and perceive pitch with this ne…

This study looks at how to best put overdose prevention practices into place in 20 permanent supportive housing buildings in New York. About 1,350 tenants and staff will help researchers see which strategies work best. The goal is to reduce overdose risks for people living in the…

This study explores whether MRI scans can help doctors predict which heart failure patients will respond well to a treatment called cardiac resynchronization therapy (CRT). Researchers will use MRI data and computer models to better understand heart function. The goal is to impro…

This study looks at whether a non-invasive device can help doctors better understand fluid levels in patients with acute decompensated heart failure. About 50 adults in the cardiac unit who need IV diuretics will have their heart function measured before and after a simple leg ra…

This study tests whether an automatic reminder in the medical record helps doctors order liver ultrasounds for patients with cirrhosis. About 1,300 adults with cirrhosis who haven't had recent imaging will be included. The goal is to see if the reminder increases screening rates …

This study looks at whether a hearing screening and counseling program during a primary care visit can help underserved older adults with hearing loss. About 120 participants will either get advice on affordable listening devices or be referred to standard audiology care. The goa…

This study tested whether a supplement called N-acetylcysteine (NAC) affects oxidative stress and inflammation differently in men and women with obstructive sleep apnea. Fourteen participants who already use standard CPAP therapy took NAC or a placebo for 4 weeks. The goal was to…

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can correctly tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. Part…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This pilot study tests a community-based educational program to raise awareness of melanoma and other skin cancers. About 45 adults in Brooklyn will attend a session led by a health worker and complete surveys and follow-ups over 12 months. The goal is to see if the program impro…