National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study tests an experimental drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing its own insulin, reducing the need for injected insulin. About 66 participants will receiv…

This study aims to better understand and treat fasting hypoglycemia, a condition where blood sugar drops too low. Researchers will test 1,500 adults with documented low blood sugar or insulin-secreting tumors. Participants undergo supervised fasting and blood tests to find the ca…

This study tests whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely reduce protein leakage in the urine of people with membranous nephropathy, a kidney disease where the immune system damages kidney filters. About 30 adults with persistent prot…

This study tests a drug called pegvisomant that blocks growth hormone in people with severe insulin resistance caused by lipodystrophy or insulin receptor gene changes. Participants will give themselves daily shots for one month and have two short hospital stays for tests. The go…

This study looks at how the liver responds to food in people with non-alcoholic fatty liver disease (NAFLD) and whether the drug semaglutide can reduce liver fat and damage. About 84 adults with NAFLD and healthy volunteers will participate. Researchers will measure liver fat, en…

This study tests whether two drugs that calm the immune system—high-dose steroids or a medicine called anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned…

This study tests whether combining two drugs, VIR-2218 and peginterferon alfa-2a, can lower hepatitis B virus levels in people with mild or inactive chronic infection. About 50 adults aged 18 to 65 will receive monthly VIR-2218 shots for 6 months and weekly peginterferon shots fo…

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study is checking how well a test called the desmopressin stimulation test can identify different types of Cushing's syndrome, a condition caused by too much cortisol. Researchers will give the test to 140 people aged 18 to 70 who have or might have Cushing's, as well as hea…

This study compares new PET scans using a radioactive tracer (18F-FCH) to standard CT scans for locating overactive parathyroid glands or tumors before surgery. About 193 adults scheduled for parathyroid removal will receive both types of scans, then undergo surgery. The goal is …

This study tests whether newer PET scans (68Ga-DOTATATE and F-DOPA) can better locate the hidden tumors that cause ectopic Cushing syndrome, a rare condition where the body makes too much cortisol. About 80 adults aged 18-90 with this condition will receive these scans along with…

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults will receive either real or fake TDCS sessions over 4 weeks, combined with a reduced-calorie diet. The goal is to see if stimula…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants. Researchers will compare people with these conditions to healthy volunteers to understand how insulin works in the body. No new treatments are t…

This study explores whether a special PET/CT scan using a compound called 68Gallium-DOTATATE can better detect thyroid cancer that has spread and is resistant to standard radioactive iodine treatment. About 54 adults with metastatic thyroid cancer will receive an injection of the…

This study looks at families with a history of small bowel carcinoid cancer to learn how the disease develops and spreads. Researchers will follow up to 1,600 participants, including those with the disease and their at-risk relatives, using advanced imaging and blood tests every …

This study aims to understand how type 2 diabetes and obesity in young people (ages 12-25) affect heart and blood vessel health over time. Researchers will follow 930 participants for up to 25 years, using yearly checkups, scans, and stress tests. No treatments or drugs are being…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study aims to find the genetic causes of primary aldosteronism—a condition where an adrenal gland tumor causes high blood pressure—in Black individuals. Researchers will study up to 1,150 participants, including those with hard-to-control blood pressure and their relatives. …

This study aims to learn more about endocrine (hormone gland) disorders by observing and treating up to 1,000 adults. Participants may receive tests like blood work, imaging, or genetic testing, and could get treatments such as surgery or medicine. The goal is to improve diagnosi…

This study tests two methods of preparing patients with advanced thyroid cancer for a special PET scan that helps plan radiation treatment. Thirty participants will receive both a hormone injection and thyroid hormone withdrawal to see which method better predicts the right radia…

This study aims to improve how we measure metabolism—the rate your body burns calories—by looking at body shape and composition. Researchers will compare healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants spend two days in the hospital f…

This study looks at families where more than one person has a common type of thyroid cancer (non-medullary). The goal is to understand how the disease runs in families, find genes that might raise risk, and figure out the best way to screen for it early. People aged 7 and older w…

This study looks at whether starting with a low-carbohydrate diet and then switching to a low-fat diet leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only delivered meals and track their weight, activity, and blood sugar at home. …

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and the immune system in healthy women aged 18-50. Researchers will compare women with a healthy weight to those with obesity. Participants will stay in the clinic for …

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns, and collect genetic samples. About 2,000 healthy adu…

This study looks at fat and muscle tissue from adults having surgery at NIH to learn how the body stores and uses energy. Researchers want to understand metabolism better, which could lead to new treatments for obesity. Participants don't need extra visits; samples are collected …

This study looks at women with lipodystrophy (a condition causing abnormal fat loss) who have been pregnant, both those who took the drug metreleptin and those who did not. Researchers will collect information on pregnancy complications and the health of the children. The goal is…

This study follows up to 8,050 people with or at risk for liver disease (like hepatitis B, C, or D) to learn how these conditions develop and progress. Participants give blood and urine samples, get yearly liver ultrasounds, and may have optional biopsies. The goal is to gather i…

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body uses fat for energy. Researchers will measure things like how many calories participants burn while sleeping and how much fat they burn. The study involves 1…

This study aims to learn more about hormone gland (endocrine) disorders in adults, such as diabetes and thyroid disease, and to train doctors in diagnosing and treating these conditions. Up to 1,250 adults aged 18 and older with a known or suspected endocrine disorder, and their …

This study looks at how changing the amount of protein, fat, carbs, and total calories in your diet affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 9 separate 24-hour p…

This study looks for better ways to measure what people eat, specifically sugar. Instead of relying on food diaries, researchers want to see if stable isotopes in blood, hair, and other samples can accurately track sugar intake. Sixty healthy adults will stay at a research center…

This study looks at brown adipose tissue (BAT), a type of body fat that may help burn energy, improve insulin sensitivity, and reduce fatty liver. Researchers will give a drug called mirabegron to women with Polycystic Ovary Syndrome (PCOS) and healthy men for 4 weeks to see how …

This study looks at why some adults who had Fontan surgery for a heart defect develop serious liver scarring. Researchers will use blood tests, imaging, and liver biopsies to track changes over time. The goal is to find early signs of liver disease and understand what causes it. …

This study collects blood samples from 250 adults with sickle cell disease, sickle cell trait, or healthy red blood cells. Researchers will use the samples to test thousands of compounds, including existing FDA-approved drugs, to find new treatments for sickle cell disease. Parti…

This study aims to learn more about how to diagnose and treat thyroid nodules and thyroid cancer. It will involve up to 2,500 people who have or may have these conditions, as well as family members at genetic risk. Participants will undergo standard medical tests like blood draws…

This study aims to understand what causes primary sclerosing cholangitis (PSC), a rare chronic liver disease. Researchers will collect blood, saliva, urine, stool, and tissue samples from 143 adults with PSC over 12 months. They will also perform imaging and surveys to gather dat…

This study looks at two ways of giving a meal test to healthy adults to measure blood sugar changes. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's body size. The goal is to find out which method produces more consi…

This study looks at whether obesity raises heart disease risk in African American men and women. Researchers will measure body fat, blood fats, and how well insulin works in 2000 healthy non-diabetic adults. The goal is to understand why heart disease risk factors may differ betw…

This study follows 400 people aged 12 and older who have or are at risk for noncirrhotic portal hypertension (NCPH), a liver condition that raises blood pressure in the liver without typical warning signs. Researchers will track participants over many years using blood tests, ima…

This study aims to learn more about kidney diseases caused by the immune system, such as nephrotic syndrome and lupus nephritis. Researchers will follow up to 2,000 adults and children over 10 years old, collecting medical history, physical exams, and blood or urine samples. The …

This study collects medical information and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal disorders. The goal is to build a resource for future research to better understand and treat these diseases. Particip…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood and urine from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goal is to …

This study aims to understand how fat is stored in people with familial partial lipodystrophy (FPLD), a condition that leads to serious health issues like diabetes and heart disease. Researchers will compare fat tissue samples from 14 participants (some with FPLD, some healthy) a…

This study aims to learn more about parathyroid disorders—conditions where the parathyroid glands produce too much or too little hormone, or the body doesn't respond properly. Researchers will follow up to 3,000 people (ages 6 months and older) who have, are at risk for, or are r…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…