National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study compares two treatments to see if a low-dose drug called ATG can delay or prevent type 1 diabetes as well as the approved drug teplizumab. About 60 people aged 4 to 35 who are at high risk (stage 2) will receive either two infusions of ATG or 14 infusions of teplizumab…

This early-stage trial tests a radioactive drug (177Lu-DOTA-EB-TATE) in 18 adults with a rare, aggressive thyroid cancer (Hurthle cell) that has spread and no longer responds to standard radioactive iodine. The drug targets a protein found in high numbers on these cancer cells. T…

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study looks at how meals with different amounts of fat, carbs, and protein change fat levels in the blood. Researchers will study 100 adults with conditions like diabetes, metabolic syndrome, or kidney disease, plus healthy volunteers. Participants will eat two different bre…

This study will collect health information and samples (blood, saliva, urine, stool) from up to 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers want to learn how diabetes and obesity develop and change over many years. Parti…

This study watches 500 adults and children getting stem cell transplants to learn why some develop liver problems. Participants have blood tests, imaging, and two liver biopsies over 4 years. No new treatments are tested; the goal is to understand risk factors and outcomes.

This study looks at how early life events might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60. Participants will have body measurements, wear activity and glucose monitors, answer questionnaires, and eat from a bu…

This study looks at how the liver processes fat in people with alcohol use disorder. Participants will have two liver biopsies: one soon after entering a detox program and another three weeks later. Researchers will compare genetic activity in the liver to understand how fat buil…