National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study looked at whether vitamin E can help adults with nonalcoholic fatty liver disease (NAFLD). Researchers tested different doses of vitamin E in 200 people to see which dose best lowers liver enzymes. The goal is to find a safe and effective dose to control the disease.

This study looked at whether people with chronic hepatitis B can safely stop taking antiviral drugs after at least 4 years of treatment. Fifteen adults who had undetectable virus levels stopped their medication and were closely monitored with monthly blood tests for 6 months, the…

This study tested whether the blood thinner clopidogrel can prevent early failure of arteriovenous fistulas (connections between an artery and vein) in people with kidney failure who need hemodialysis. 877 adults were enrolled. The drug reduced the risk of fistula blockage but di…

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. 123 women participated, receiving either weekly group sessions on diet and activity or enhanced standard care. The goal was to see if these programs c…

This study tested a new, less invasive way to measure stomach acid using a wireless capsule (SmartPill) that you swallow. It compared the capsule to the standard method that uses a tube placed through the nose into the stomach. The study included healthy volunteers and people wit…

This study looked at whether taking the hormones hydrocortisone (a form of cortisol) and melatonin can ease jet lag symptoms after a long eastward flight. Fifty-seven adults aged 18 to 65 who flew across 6-8 time zones took either one or both hormones or a placebo for four days a…

This study tested whether pregabalin, a drug used for nerve pain, can reduce symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. 324 participants received either pregabalin or a placebo for 6 weeks. The main goal was to see if pain, urinary symptoms, and qualit…

This study looked at whether quercetin, a compound found in foods like apples and onions, changes how the body absorbs sugar. Researchers gave 24 obese adults, some with type 2 diabetes, either quercetin or a placebo during a sugar-drink test. They measured blood sugar levels to …

This study tested whether amitriptyline, a drug typically used for depression, can reduce pain and frequent urination in people newly diagnosed with painful bladder syndrome. About 271 adults took part. The goal was to see if the drug improves overall symptoms after 12 weeks comp…

This study tested whether a ceramide-based foot cream, used twice daily for two weeks, could reduce water loss and dryness in the feet of people with non-insulin dependent diabetes. Ten adults with moderate to severe foot dryness took part. The goal was to see if the cream could …

This study looked at how to find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests to locate tumors and checked for a related genetic condition called MEN1. The goal was to improve diagn…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 took part. They stayed in a special room that measured their calorie burn, and res…

This study looked at how lean and obese people differ in their sense of thirst and how their bodies handle water. Researchers had 75 healthy men stay in the hospital for 13 days and undergo tests like going without water for 24 hours. The goal was to understand if body fat change…

This study looked at how people with non-alcoholic fatty liver disease (NAFLD) process food compared to those without it. Researchers monitored 53 adults during a 2-day hospital stay, measuring metabolism and blood changes after meals. The goal was to better understand what cause…

This study looked at how many organ transplant recipients have been exposed to the hepatitis E virus. Researchers tested blood from 447 adults who had a liver, kidney, or small bowel transplant, or were waiting for one. The goal was to find out if hepatitis E is a hidden problem …

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after giving different doses and meals. The goal was to learn more about vitamin E needs in wome…

This study looked at how well COVID-19 vaccines protect people with chronic liver disease, including hepatitis B, C, NAFLD, and NASH. Researchers followed 233 adults for 6 months, checking their immune response through blood tests and questionnaires. The goal was to see if liver …

This study aims to find genetic markers that may increase the risk of developing focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers will compare DNA from 616 people, including African-Americans with FSGS, African-Americans wit…

This study looked at how the body burns calories when exposed to different temperatures, from about 61°F to 88°F. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. Healthy men and women stayed in a h…

This study aims to learn more about kidney diseases that cause scarring, such as focal segmental glomerulosclerosis (FSGS) and chronic kidney disease of unknown cause (CKDu). Researchers will collect blood, urine, and kidney tissue from 537 participants to study how these disease…

This study looked at why foreign-born adults in the US often don't get the care they need for chronic hepatitis B. Researchers surveyed 274 people born outside the US about their background, how well they've adapted, and their healthcare experiences. The goal was to find barriers…

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians and Caucasians, to understand risk factors for obesity. Participants filled out ques…

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Some participants took diabetes medicine with or without extra insulin to see if resting the pancreas could help it make more insulin. The study also compared them to healthy volunteers to …

This study followed over 8,600 children from birth to identify what in the environment—like viruses or diet—might trigger type 1 diabetes in those with a genetic risk. Researchers collected blood and stool samples to track when the immune system first attacks the pancreas. The go…

This study looked at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency is common in these patients but hard to diagnose. Researchers measured hormone levels in 225 participants to better understand the condition and imp…

This study looked at how stress from the COVID-19 pandemic and changes in the food environment influenced eating behaviors and weight in adults. Over 5,000 English-speaking adults aged 18 and older completed online surveys about their mental health, eating habits, and weight chan…

This study followed over 12,000 people from the Gila River Indian Community for decades to understand type 2 diabetes and its complications. Participants received regular check-ups every two years, including glucose tests and physical exams. The goal was to learn how diabetes dev…

This study looked at how bacteria from the intestines might travel to the liver and blood in people with hepatitis C-related liver disease. Researchers wanted to understand why this happens and if it makes liver disease worse. Thirty adults with stable liver disease participated,…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if race affects how we screen for diabetes and heart disease. Participants had blood tests, body fat measurements, and meal tests over four visits. The goal was to find the best scre…

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and lifestyle factors. About 1,759 overweight adults aged 18-55 took part in tests measuring how their bodies handle sugar and store energy. The goal was to find genetic markers and early…

This study looked at how the amount of water a person drinks affects the level of vitamin C in their blood. Healthy adults aged 18-35 followed a low-vitamin C diet and then received increasing doses of vitamin C by mouth and through an IV. Researchers collected blood and urine sa…

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men ate carefully controlled diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers could reliab…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…