National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study tests two experimental drugs (abrocitinib and ritlecitinib) to see if they can help preserve the body's ability to make insulin in people recently diagnosed with type 1 diabetes. The trial involves 78 participants aged 12 to 35 who were diagnosed within the last 100 da…

This study tests whether giving two immune-modulating drugs (rituximab followed by abatacept) can better preserve the body's ability to produce insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will be followed…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to diabetes and high blood fats. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study gives the drug metreleptin to people with partial lipodystrophy, a rare condition that causes abnormal fat storage, high blood fats, and diabetes. Participants have already shown improvement from metreleptin in earlier studies and cannot get the drug elsewhere. The goa…

This study looks at American Indians with type 2 diabetes who have kidney problems. Researchers want to see if a past treatment with the drug losartan still helps protect their kidneys years later. Participants will have tests like blood and urine samples, and some will get a kid…

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study looks at the DNA of over 9,000 people with diabetes and kidney disease, along with their family members, to find genes that increase the risk of diabetic kidney disease. Researchers are collecting blood samples and health information to identify genetic markers. The go…

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…