Centre Oscar Lambret

This study looked at 133 people with a first-time head, neck, or lung cancer who were still smoking. It compared two groups: one that received a structured addiction treatment program as part of their cancer care, and another that only got advice to seek help. The goal was to see…

This study tested a precise, high-dose radiation treatment (CyberKnife) for people with a single liver tumor who could not have standard therapies. 44 adults received three radiation sessions over 8-10 days. The main goal was to see how many patients had no tumor growth 18 months…

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps control advanced breast cancer longer. 51 adults with HER2-negative breast cancer that had spread or returned took part. The main goal was to see if the combination kept the cancer fro…

This study looked at whether adding the diabetes drug metformin to standard chemo-radiation helps shrink rectal tumors before surgery. 60 adults with locally advanced rectal cancer took part. The main goal was to see if more patients had no cancer cells left in the removed tumor.…

This study tested a combination of two drugs, Fluvastatin and Celebrex, in 20 children and young adults with certain types of brain tumors (gliomas) that had come back or not responded to treatment. The main goal was to find the safest dose of Fluvastatin when given with a fixed …

This study tested the drug regorafenib in 219 people with soft tissue sarcoma that had spread and was no longer responding to standard chemotherapy. The goal was to see if the drug could slow down the cancer's growth. Participants were randomly assigned to receive either regorafe…

This study tested whether the drug regorafenib can help keep advanced soft tissue sarcoma from growing after initial chemotherapy. 127 adults whose cancer was stable or shrinking after six cycles of chemo were randomly assigned to receive either regorafenib or a placebo. The main…

This study looked at 106 people with esophageal or junction cancer that could be removed by surgery. Before surgery, patients received either a standard three-drug chemo (FOLFOX) or a two-drug combo (paclitaxel plus carboplatin) along with radiation. The goal was to see which app…

This study tested two treatments for people with advanced angiosarcoma, a rare cancer of blood vessels, that cannot be removed by surgery. Participants received either a chemotherapy drug called paclitaxel alone or paclitaxel plus another drug called bevacizumab. The goal was to …

This study tested the safety of a drug called cilengitide when given together with radiation therapy to children and young adults with a rare and aggressive brain tumor called diffuse intrinsic pontine glioma (DIPG). The goal was to find the highest safe dose. 32 participants wer…

This early-phase study tested a combination of two chemotherapy drugs (paclitaxel given weekly by IV, and cyclophosphamide taken daily by mouth) in 28 adults with advanced cancer who had no other treatment options. The main goal was to find the safest dose of the combination and …

This study tested a new radiation plan for men with intermediate-risk prostate cancer. 76 participants received standard radiation to the prostate and nearby glands, plus an extra-high dose of radiation (stereotactic boost) directly to the tumor. The goal was to improve cancer co…

This study tested two treatments for people with advanced cancer who had no other options. One group received a low-dose chemotherapy pill (cyclophosphamide) taken daily, and the other group received a hormone pill (megestrol). The main goal was to see how many patients in each g…

This study looked at 53 adults with advanced soft tissue or uterine sarcoma who had stable disease or responded after six cycles of trabectedin. Half continued the drug, while the other half took a break (drug holiday). The goal was to see which approach better delayed cancer gro…

This early-phase study tested a combination of two cancer drugs, imatinib and cyclophosphamide, given continuously at low doses (metronomic schedule) in 26 people with rare, advanced tumors that had no standard treatment options. The main goal was to find the highest safe dose of…

This study involved 57 adults with advanced head and neck cancer who were treated with both radiation and the drug cetuximab. The main goal was to track skin side effects caused by this combination. Researchers also measured quality of life and how well the treatment worked again…

This study looked at which of two oral chemotherapy drugs (Xeloda or UFT with folinic acid) people with advanced colorectal cancer prefer. After trying both treatments in a crossover design, patients chose their favorite. The study also checked how safe each drug was. 89 adults w…

This study tested whether a personalized, remote exercise and physical activity coaching program could improve quality of life in women who had completed treatment for early-stage breast cancer. Over 800 participants were randomly assigned to receive either the coaching or standa…

This study looked at whether adding ketoprofen to standard paracetamol (acetaminophen) can better control pain during and after brachytherapy, a type of internal radiation. 68 adults with cervical or upper airway/digestive tract cancer took part. The goal was to find a simple, st…

This study tested whether using a drain to actively remove gas from the belly after keyhole gynecologic surgery (laparoscopy) reduces shoulder and rib pain compared to manually pushing the gas out. About 200 women having surgery for benign or cancerous conditions took part. The g…

This study tested a special LED lamp to treat painful mouth sores caused by radiation therapy in 28 people with head and neck cancer. The goal was to see if the light could stop sores from becoming severe enough to need a feeding tube. Researchers checked the sores weekly and mea…

This study looked at whether a special numbing method called PECS, given during mastectomy, can lower the chance of chronic pain 6 months later. It involved 194 breast cancer patients having a mastectomy, with or without lymph node removal or breast reconstruction. The approach a…

This study looked at whether sentinel lymph node biopsy (a way to check if cancer has spread) works well in women who have more than one tumor in the same breast. 216 women with multifocal breast cancer took part. The main goal was to see how often doctors could find the sentinel…

This study looked at how breast cancer impacts the quality of life of young women (under 45) and their life partners. Researchers interviewed couples at different times during medical follow-up to understand their experiences. The goal was to create a questionnaire that helps doc…

This study aimed to find protein patterns (proteomic signatures) in tumor samples and blood that could predict how well breast cancer responds to chemotherapy given before surgery. Researchers analyzed samples from 66 women with breast cancer who had not received prior chemothera…

This study looked at the challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured the burden felt by both the patient and their main caregiver using surveys. The goal was to find factors that h…

This study looked at whether using a PET-scan on the first day of brachytherapy (a type of internal radiation) is possible for people with advanced cervical cancer. Fourteen patients who had already received chemoradiation took part. The main goal was to see if the PET-scan could…

This study gathered medical and social information from 2914 cancer patients aged 65 and older who visited a geriatric oncology clinic. The goal was to create a database to help doctors better understand this group and improve care. No treatments or medications were tested.

This study followed 385 adults with a first-time lung or head and neck cancer to see how many continued smoking or drinking alcohol over the first year. Researchers also looked at how these habits affected cancer progression and survival. The goal was to understand risk factors f…

This study used functional MRI (fMRI) to see how the brain's sensory map changes after breast reconstruction surgery. Researchers scanned 49 women who had one breast reconstructed after mastectomy. The goal was to objectively measure how the brain responds to touch on the reconst…

This study looked at 386 women with cervical, uterine, or ovarian cancer to compare complication rates between standard laparoscopic surgery and robot-assisted laparoscopic surgery. The goal was to see which approach leads to fewer problems within the first six months after the o…

This study followed 65 rectal cancer patients who had a second surgery to reconnect their bowel after tumor removal. Researchers used a standard questionnaire to measure bowel symptoms and their impact on quality of life one year later. The goal is to identify which patients may …

This study looked at whether analyzing proteins in spinal fluid can help identify breast cancer that has spread to the lining of the brain. Seven adults with suspected spread provided fluid samples during their diagnosis. The goal was to learn more about the disease, not to test …

This study analyzed blood samples from breast cancer patients to find genetic factors that might predict how well they respond to chemotherapy. Researchers focused on patients who received common chemo drugs like anthracyclines or taxanes. The goal was to identify biomarkers that…

This study looked at how long people with advanced colorectal cancer lived after taking regorafenib, a drug given when other treatments stop working. Researchers followed 704 patients in France who received the drug through a special access program. The goal was to see real-world…

This study analyzed lung cancer tissue from 56 patients to look for pieces of a protein called Met. Researchers compared tumor samples with healthy tissue to see which fragments were present and whether they were active. The goal was to better understand the disease, not to test …

This study looked at how different hormone therapies affect memory in postmenopausal women with breast cancer. 44 women were randomly assigned to take either an aromatase inhibitor (letrozole, anastrozole, or exemestane) or tamoxifen citrate. The main goal was to measure changes …

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast tumors larger than 2 cm had a PET scan before and after their first chemo cycle. The goal was to see if changes in the scan could i…

This study looked at 28 people with breast cancer that spread to the bones. The goal was to see if two types of scans, PET-CT and whole-body MRI, give the same results when checking if treatment is working. The findings could help doctors better decide whether to continue or chan…

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests of 154 patients. They also checked if muscle …

This study looked at how emotional skills of young women (45 or younger) with non-spreading breast cancer and their partners affect their ability to adjust to the disease. Over 390 couples were followed from chemotherapy through recovery. The goal was to understand how emotions i…

This study looked at healthy skin tissue from 58 adults in two age groups (18-40 and 55+) to understand why cancer risk rises with age. Researchers checked for signs of cell aging and DNA damage that might make cells more likely to turn cancerous. The goal was to learn more about…

This study tested a new questionnaire to measure quality of life in young women (under 45) with non-metastatic breast cancer and their partners. Over 1000 couples participated by filling out surveys at home. The goal was to see if the questionnaire accurately captures their well-…

This study looked at how common frailty is among people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also checked whether the test results matched the docto…

This study looked at whether cancer patients who join clinical trials feel more anxious or depressed than those getting standard treatment. Researchers asked 125 people with advanced solid tumors or blood cancers to fill out questionnaires about their stress, mood, and quality of…

This study created a regional database of 518 adults with non-small cell lung cancer who had a gene mutation. Researchers collected detailed clinical information, such as age, smoking history, and cancer stage, to see how these factors relate to different mutations. The goal was …