Centre Oscar Lambret

This study tested whether patients with advanced esophageal cancer should continue chemotherapy after an initial 6-week treatment if their disease hasn't progressed. All participants received 6 weeks of chemotherapy first. Those whose cancer hadn't grown were then randomly assign…

This study tested whether adding extra chemotherapy after standard radiation treatment could help control advanced cervical cancer that had spread to abdominal lymph nodes. The trial involved 21 patients who first received standard radiation with chemotherapy, then received addit…

This study tested whether adding a follow-up chemotherapy drug (gemcitabine) after standard radiation and chemotherapy could better control advanced cervical cancer. It involved 19 women with stage IB2 to IVA cervical cancer who had not received prior cancer treatments. The trial…

This study tested whether the drug imatinib could help control metastatic ocular melanoma, a serious cancer that starts in the eye and spreads. It involved 13 adult patients whose cancer had spread to other parts of their body. The main goal was to see if the treatment could stop…

This study tested a new approach to reduce side effects from radiation treatment for intermediate-risk prostate cancer. Researchers implanted a small, biodegradable balloon between the prostate and rectum to create space and protect healthy tissue. They measured if this allowed f…

This study tested whether a special imaging technique called Narrow Band Imaging (NBI) could help surgeons see the edges of oral cancer tumors more clearly during surgery. It involved 23 adults with newly diagnosed, untreated oral cavity cancer who were scheduled for surgery. The…

This study tested whether giving radiation to the brain could prevent cancer from spreading there in patients with a specific type of advanced breast cancer (HER2-positive). Patients were already receiving standard treatment with trastuzumab (Herceptin) and chemotherapy. The goal…

This study tested whether personalized psychological support helps breast cancer survivors return to work compared to standard care. Researchers worked with 128 women who had jobs before diagnosis, providing some with four counseling sessions during and after treatment. The goal …

This study aimed to understand how radiosurgery treatment affects the quality of life of patients with brain metastases. Fifty-two patients with up to five brain tumors answered detailed questionnaires about their physical, mental, and cognitive well-being before treatment and fo…

This study tested a brief phone-based therapy to help patients and their partners cope with the emotional trauma of receiving news that their cancer is advanced and incurable. The therapy combined deep breathing exercises with a technique to help people structure their traumatic …

This study aimed to see if a mechanical stimulation device works better than standard massage to reduce pain and improve shoulder movement for breast cancer patients after mastectomy surgery. It planned to enroll 80 patients needing physical therapy and compare their pain levels,…

This study aimed to understand why people with head and neck cancers delay seeing a doctor after their first symptoms appear. Researchers interviewed 90 patients to learn how emotional and social factors affect this decision. The goal was to identify barriers to early medical car…

This study aimed to understand why cervix cancer sometimes comes back after standard radiation and chemotherapy. Researchers tested whether a lack of oxygen (hypoxia) in the tumor during early treatment could predict if the cancer would be controlled. They enrolled 9 patients wit…

This study aimed to understand if the types of bacteria in a person's gut before starting cancer treatment are linked to how well their rectal cancer responds to that treatment. Researchers planned to analyze stool samples from patients with stage II or III rectal cancer before t…

This study aimed to understand how high-dose radiation therapy affects the immune system in cancer patients. Researchers followed 28 people with liver, colorectal, melanoma, or kidney cancers, taking blood samples before, during, and after their radiation treatments. The goal was…

This study aimed to understand why some breast cancer cells become resistant to chemotherapy. Researchers analyzed tumor and blood samples from 56 women before, during, and after standard chemotherapy treatment. The goal was to learn how certain aggressive 'cancer stem cells' eme…

This study aimed to see if a simple blood test (liquid biopsy) could be as accurate as a traditional tissue biopsy for finding specific genetic changes in lung cancer. Researchers compared results from both methods in 21 patients with advanced lung cancer who had not yet started …

This study aimed to learn how the body's immune cells behave in women with advanced ovarian or fallopian tube cancer. Researchers collected blood and tissue samples from 36 participants before and after their standard chemotherapy treatment. The goal was to describe the immune sy…

This study aimed to understand how standard chemotherapy treatments for breast cancer affect the future fertility of young women. Researchers followed 135 women under age 38, measuring key hormones and ovarian markers before, during, and for two years after chemotherapy. The goal…

This was a laboratory study that tested two different sources of human cells to see which one could be better for making a non-stick medical patch. Researchers collected small tissue samples from six patients during surgery and grew the cells in a lab. The goal was to compare the…