Centre Oscar Lambret

This study tests a combination of an immunotherapy drug (nivolumab) and low-dose chemotherapy in children and teenagers whose solid tumors have returned or not responded to standard treatments. The goal is to see if the combo is safe and can help control the cancer longer. About …

This study tests whether starting chemotherapy earlier and continuing it longer can help adults with glioblastoma, an aggressive brain tumor, live longer. About 486 participants are randomly assigned to either the standard treatment or an intensified plan. The goal is to see if t…

This study tests a precise type of radiation called SBRT for people with liver cancer or tumors that spread to the liver from other cancers. About 280 adults who cannot join other trials will receive SBRT. The goal is to see how well it controls tumor growth and what side effects…

This phase 3 trial tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with stage III ovarian cancer live longer without the disease coming back. About 362 participants will receive either standard surgery alone or surgery plus the heate…

This study was designed to see if analyzing tiny particles called exosomes in spinal fluid could help doctors diagnose breast cancer that has spread to the lining of the brain. It planned to enroll breast cancer patients with suspected spread and compare the exosome protein patte…

This study tests a surgery called radical fimbriectomy for women with BRCA mutations who are at high risk for pelvic cancer but want to avoid removing their ovaries. The surgery removes only the fallopian tubes, where many of these cancers start, while keeping the ovaries working…

This study follows 500 women with breast cancer who receive targeted radiotherapy after lumpectomy or mastectomy. The goal is to track side effects and quality of life during and after treatment. Researchers aim to understand how well patients tolerate this type of radiation and …

This study aims to create the largest French group of people diagnosed with aggressive fibromatosis (a rare, non-cancerous tumor) since 2016. Researchers will collect medical and genetic information to better understand the disease and its link to a hereditary condition called fa…

This study looks at whether it is safe and possible for young women with early breast cancer to freeze their eggs or embryos before starting chemotherapy. The goal is to help preserve their ability to have children later. About 140 women aged 18 to 38 will take part, and research…

This study looks at long-term fertility in young women treated for breast cancer. It follows 132 patients who had chemotherapy, some with and some without a procedure to freeze eggs beforehand. The goal is to see how many become pregnant and give birth years later, helping doctor…

This study looks at 25 women with advanced breast cancer to understand why the drug Palbociclib stops working over time. Researchers collect blood and breath samples before and after the cancer progresses. The goal is to find molecular changes that signal resistance, which could …

This study follows 100 head and neck or lung cancer patients who smoke or used to smoke. Researchers want to see what helps them stay away from cigarettes after they finish radiation or chemoradiation. Patients are checked at 1, 6, and 12 months after treatment ends. The goal is …

This study compares a newer, less invasive approach called sentinel node biopsy to the usual staging methods for women with early-stage endometrial cancer that has a medium or high chance of coming back. The goal is to see if the newer method causes fewer side effects while still…