Centre Hospitalier Universitaire, Amiens

This study compares two approaches for people with a severe leaky heart valve (mitral regurgitation) who have no symptoms yet. Half will get early valve repair surgery, while the other half will be monitored closely every 6 months. The goal is to see which strategy leads to fewer…

This study tests whether using a simple urine test to guide the dose of a water pill (furosemide) can safely and effectively remove excess fluid after heart surgery. About 102 adults having heart surgery with a heart-lung machine will be randomly assigned to either standard care …

This study is testing face transplant surgery in 5 people with severe facial injuries that cannot be repaired with standard methods. The goal is to see if the surgery can restore basic functions like mouth closure and feeling in the face. To help the body accept the new tissue, p…

This study tests whether adding an inhaled form of the antibiotic amikacin (ARIKAYCE) to standard treatment helps clear Mycobacterium xenopi from the lungs faster. About 190 adults with this rare, hard-to-treat lung infection will receive either standard care alone or standard ca…

This study tests whether sirolimus, a drug used to prevent organ rejection, can shrink severe arteriovenous malformations (AVMs) and ease symptoms. About 50 people aged 2 and older with advanced AVMs will take the drug for a year. The goal is to see if the drug reduces AVM size b…

This study compares two antibiotics, clarithromycin and azithromycin, for treating MAC lung infections, a serious bacterial lung disease. About 424 adults with MAC infection will receive one of the two drugs alongside standard treatments. The goal is to see if azithromycin works …

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study tests whether a smartwatch (Withings ScanWatch) can diagnose atrial fibrillation that occurs after heart surgery better than standard monitoring. About 324 adults who had on-pump heart surgery will either use the smartwatch or receive usual care. The goal is to catch s…

This study is testing whether a simple saliva sample can help diagnose oral squamous cell carcinoma (a type of mouth cancer) by looking for specific DNA changes. Researchers will collect saliva from 30 patients with oral cancer and 30 healthy controls, and again from the cancer p…

This study aims to screen 300 children aged 2 to 18 for familial hypercholesterolemia, a genetic condition that causes very high cholesterol and greatly increases heart disease risk in adulthood. A small blood sample is taken after fasting to measure cholesterol levels. The goal …

This study looks at whether adding an early PET scan right after the injection can better tell the difference between a brain tumor coming back and damage from radiation therapy. About 50 adults with brain metastases who already need a PET scan will get an extra 15-minute scan ri…

This study tests whether a new, faster cardiac MRI that uses artificial intelligence can accurately measure heart function in people with left ventricular hypertrophy (thickened heart muscle). The standard MRI requires multiple breath-holds, which can be hard for elderly or breat…

This study is testing whether a blood test measuring a protein called p-Tau217 can diagnose Alzheimer's disease as accurately as the current method, which requires a spinal tap. Researchers will compare results from blood and spinal fluid samples from 40 adults with suspected Alz…

This study tests whether an intelligent video system that automatically detects falls can reduce hospital visits better than a standard button-based alarm. About 395 adults aged 75+ who are at risk of falling will be followed for 90 days after returning home. The goal is to see i…

This study tests whether using a virtual reality headset (HypnoVR) can reduce discomfort in patients recovering in the intensive care unit after major heart, chest, or abdominal surgery. 194 adults will be randomly assigned to either standard care or twice-daily VR sessions for 1…

This study will test whether using an oscillating PEP (OPEP) device improves quality of life for 60 children and adults with bronchiectasis. Participants will fill out questionnaires before and after using the device. The goal is to see if the device helps with daily life and tre…

This study tests whether a virtual reality headset that plays hypnotic stories and images can reduce anxiety and resistance during hygiene care for people with Alzheimer's disease. Researchers will compare the VR approach to standard care in 24 patients living in a long-term care…

This study tests whether attaching a small cap to the endoscope helps doctors find and treat the source of upper gastrointestinal bleeding more quickly. About 72 adults with severe bleeding will be randomly assigned to have an endoscopy with or without the cap. The main goal is t…

This study is testing whether hypnosis can lower anxiety in people having facial surgery under local anesthesia. Sixty-six adults who are at least mildly anxious will either get standard care or extra hypnosis support. Researchers will measure anxiety levels before and after surg…

This study looks at whether using a co-dodo crib (a bedside sleeper) helps breastfeeding mothers and their newborns sleep better and bond more closely, compared to a standard crib. About 132 mothers and their full-term babies will be randomly assigned to use either a co-dodo or s…

This study tests whether using virtual reality at home can help people with recent facial palsy (within the last year) reduce involuntary facial spasms called synkinesis. About 100 participants will either use a VR self-rehabilitation program or follow standard rehabilitation exe…

This study tests whether extra nutrition support before and after surgery helps head and neck cancer patients avoid weight loss. Sixty adults having surgery for head and neck cancer will be split into two groups: one gets standard care, the other gets personalized diet advice, a …

This study compares two relaxation tools—special glasses (Psio) and a virtual reality headset—against no relaxation tool to see which best reduces anxiety before orthopedic surgery. About 632 adults will be randomly assigned to one of the three groups. The goal is to improve pati…

This study compares two treatments for children with overactive bladder (OAB) of unknown cause: the standard medication oxybutynin and a nerve stimulation therapy (PTNS). About 124 children aged 6 to 16 will be randomly assigned to one treatment for three months. The goal is to s…

This study tests whether giving a long-acting inhaled medication before and after lung cancer surgery can lower the chance of serious lung complications. It includes 266 adults with lung cancer who are at high risk for these problems. Participants will receive the inhaled treatme…

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study is testing whether a quick, non-invasive ultrasound measurement of blood flow in the foot can predict major problems like limb loss or heart attack in people with severe peripheral artery disease (PAD). Researchers will follow 134 patients for 6 months after surgery to…

This study is testing a special type of MRI that can measure blood flow in the branches of the external carotid artery. The goal is to see if this technique works well in both healthy people and those with certain medical histories, such as prior radiation therapy or surgery. If …

This study looks at bone marrow stem cells from 50 people with Waldenström macroglobulinemia, a rare blood cancer. Researchers want to see how these cells differ from healthy ones and how they might help the cancer grow. The goal is to better understand the disease, which could l…

This study looks at a rare liver condition called Porto-Sinusoidal Vascular Disease (PSVD), which causes high blood pressure in the liver's veins. Researchers want to see if a procedure called TIPS works as well for PSVD patients as it does for those with cirrhosis. They will com…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if they get pregnant naturally, use stored eggs or tissue, or decide not to have children. The goal is to improve support and care for femal…

This study is looking at whether small pieces of tumor DNA found in the blood after treatment can predict if Waldenström Macroglobulinemia will come back. Researchers will follow 90 patients for up to 3 years after their first 6 months of therapy. The goal is to see if this DNA t…

This study uses leftover tissue from heart and orthopedic surgeries to learn more about how calcification (hardening) happens in bones and blood vessels. Researchers will grow cells from these tissues in the lab to study the process. The goal is to better understand the disease, …

This study looks at how certain immune cells called monocytes affect the success of CART cell therapy in people with multiple myeloma. Researchers will measure monocyte levels and types before and after treatment in 25 patients. The goal is to find clues that could help predict w…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy and after childbirth, as well as pregnancy outcomes and treatments needed. The goal is to better understand…

This study explores how targeted brain stimulation can improve movement speed in people who have had a stroke. Researchers will first test the technique in 60 healthy volunteers, then in 20 stroke patients. The goal is to understand which brain areas control action speed and whet…

This study looks at how hearing sensitivity (hyperacusis) might help language skills in children and adults with Williams syndrome. Researchers will use EEG and NIRS brain scans along with questionnaires to compare participants with Williams syndrome, Down syndrome, and typical d…

This study looks at three drugs (bevacizumab, ranibizumab, and aflibercept) used to treat age-related macular degeneration (AMD), a leading cause of blindness in older adults. Researchers will analyze costs and quality of life for 600 patients in France to see which treatment off…

This study tests whether placing 15 houseplants in two hospital lab rooms can reduce formaldehyde levels in the air and in workers' urine. Formaldehyde is a toxic chemical used to preserve tissue samples. Thirty adult lab staff will have their exposure measured before and two mon…

This study aims to find genetic changes that cause orofacial clefts (like cleft lip and palate) but are missed by standard tests. Researchers will use a new, high-resolution DNA mapping method called optical genome mapping on 26 people with clefts who have no known genetic diagno…

This study aims to find out how common anti-annexin A2 antibodies are in people hospitalized with COVID-19 and whether these antibodies are linked to lung damage or blood clots. Researchers will test blood samples from 300 adult patients at one hospital. The goal is to see if the…

This study looks at whether it is safe to stop antibiotics early in elderly patients (65+) hospitalized for a viral lung infection. Many patients get antibiotics even when they have a virus, which can cause side effects and lead to antibiotic resistance. Researchers will compare …

This study explores whether intravenous (IV) fluids given to mothers during labor are linked to how much weight formula-fed newborns lose in their first two days. Researchers will review medical records of 200 mothers and their full-term babies at a French hospital. The goal is t…

This study looks at how narcolepsy (types 1 and 2) and idiopathic hypersomnia affect social cognition—skills like recognizing emotions and making decisions. Researchers will give 75 adults several questionnaires to measure attention, impulse control, empathy, and emotion recognit…

This study looks at how pesticides and the bacteria living in the gut and reproductive organs may be linked to infertility in women with endometriosis. Researchers will measure DNA damage and compare these factors between 160 women with and without the condition. The goal is to f…

This study looks at why people with Alzheimer's disease may move more slowly. Researchers will use brain MRI scans and simple reaction time tests in 155 participants with mild cognitive impairment or early dementia. The goal is to link brain lesions to attention-related motor slo…

This study looks at whether blood clotting tests work the same whether the blood comes from an artery or a vein during heart surgery with a bypass machine. Researchers will take paired blood samples from 201 patients and test them using the Hemochron Signature Elite device. The g…

This study is looking at how blood sugar levels change throughout the day in women with polycystic ovary syndrome (PCOS). Researchers will use a continuous glucose monitor for 14 days to compare glucose patterns across four different PCOS subtypes. The goal is to better understan…

This study looks at cancer patients who have a type of blood clot called superficial venous thrombosis (SVT). About 15-20% of SVTs happen in people with cancer, but there are no clear treatment guidelines for them. Researchers will observe 1,576 patients to see how different bloo…

This study looks at why some lupus patients get false positive results on tests for HLA antibodies, which can make it harder to get an organ transplant. Researchers will study 30 adults with lupus who have no known risk factors for these antibodies. The goal is to find better way…

This study looks at whether measuring the function of the right upper heart chamber using ultrasound can help predict a common irregular heartbeat (atrial fibrillation) that often occurs after heart surgery. About 334 adults scheduled for bypass surgery will have their heart func…

This study looks for new genetic causes of congenital sideroblastic anemias, a group of rare blood disorders where the body cannot properly use iron to make red blood cells. Researchers will analyze DNA from 20 people whose genetic cause is still unknown. The goal is to find and …

This study aims to identify the key factors that lead to complications or death after major non-cardiac surgery. Researchers will analyze data from 350 adult patients who had abdominal, orthopedic, or vascular surgery lasting over two hours. The goal is to better understand these…

This study looks at the immune system of 150 women who have had repeated IVF failure or unexplained miscarriages. Researchers will compare immune cells and markers in their blood to find patterns that might explain why some pregnancies don't succeed. The goal is to identify bioma…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection that affects the whole body. Researchers will use existing heart ultrasound data from 60 adults to see if the measurements agree and can b…

This study uses eye-tracking technology to see how people with facial palsy pay attention to faces with abnormal movement, compared to healthy volunteers. Researchers want to understand if patients focus differently on the affected side of the face. The goal is to learn more abou…

This study aims to find genetic factors that cause cleft lip and palate, a common birth condition. Researchers will analyze the DNA of 30 people with the condition using a technique called whole exome sequencing. The goal is to better understand the genetic roots of this conditio…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study follows 232 people with a bicuspid aortic valve (a heart valve with two flaps instead of three) over 10 years. Researchers want to learn how the condition naturally progresses and what factors lead to serious problems like valve disease or bulging of the aorta. Partici…

This study tests a new, less invasive way to check diaphragm function in patients on breathing machines. Researchers will use ultrasound to measure diaphragm movement during a spontaneous breathing trial. The goal is to see if this method can help doctors decide when patients are…

This study aims to develop a way to measure facial muscles using MRI scans in people with facial paralysis. Currently, doctors rely on subjective scales to assess muscle function, but this method could provide objective measurements like muscle thickness and volume. The goal is t…

This study looks at a protein called annexin A2 on the surface of certain white blood cells (monocytes) in people with antiphospholipid syndrome, a condition that raises the risk of blood clots and pregnancy complications. Researchers will compare the amount of this protein betwe…

This study looks at how a newborn's brain and blood flow work together in the first minutes after birth. Researchers will place a small patch on the baby's scalp to measure brain activity and oxygen levels. The goal is to learn more about how babies adjust to life outside the wom…

This study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…

This study looks at whether taking a hot bath before or after muscle-damaging exercise helps muscles recover faster. Researchers will measure muscle function and a protein called HSP70, which helps protect and repair cells. The study involves 96 healthy young male athletes who ex…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study checks how well the eCential surgical robot places screws in the spine during surgery. About 45 people aged 5 and older who need spinal screws will take part. The goal is to see if the robot improves screw placement accuracy and reduces complications.

This study tests whether a quick, finger-prick blood test for C-reactive protein (CRP) can predict a serious complication called anastomotic leak after planned colorectal surgery. The goal is to catch leaks earlier, reduce the need for repeated blood draws, and help patients reco…

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study looks at a serious condition where the heart fails to pump blood and blood vessels widen too much, often after a heart attack or heart surgery. Researchers will review medical records from 2,500 adults in French hospitals to learn more about who gets this condition and…

This study looks at how feelings of resentment and forgiveness impact the quality of life of people living with HIV. Researchers will follow 206 participants for one year to see if a forgiving attitude is linked to better well-being. The goal is to understand how forgiveness migh…

This study tests whether a robot can help surgeons place bone tunnels more accurately during ACL knee reconstruction. Thirty patients aged 10 to 45 with ACL tears will have surgery using the Rosa robot to guide tunnel placement. The goal is to see if robotic assistance improves p…

This study compares a new, high-resolution DNA mapping technique (optical genome mapping) with standard methods to detect genetic changes in patients with certain blood cancers (polycythemia vera, essential thrombocythemia, or myelofibrosis). The goal is to see if the new method …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…