Could stopping antibiotics early help elderly virus patients?

NCT ID NCT07030673

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether it is safe to stop antibiotics early in elderly patients (65+) hospitalized for a viral lung infection. Many patients get antibiotics even when they have a virus, which can cause side effects and lead to antibiotic resistance. Researchers will compare how many days patients are off antibiotics and track side effects, deaths, and hospital stay length.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 256 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥ 65 years affiliated to a social security scheme * Hospitalized for a lower respiratory infection defined as: * the presence of 2 of the following 4 signs: * hyperthermia \>38°C, * hyperleukocytosis ≥12000 or ≤4000, * purulent aspirations/sputum, * rales on pulmonary auscultation indicating parenchymal damage * associated with a pulmonary image (standard X-ray, CT scan or ultrasound) * Microbiological diagnostic sample taken within 48 hours * Informed consent of the patient or their representative Exclusion Criteria: * Hospitalization planned for \< 48 hours or transfer planned to another center within 7 days * Patient in septic shock, * Febrile aplasia * Absence of diagnostic microbiological sampling (\> 48 hours after admission) * Moribund patient, * Death expected within the week * Inhalation proven by endoscopy or eyewitness * Purulent pleurisy, lung abscess, or other concomitant bacterial infection requiring antibiotic therapy.

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Conditions

The condition(s) this trial relates to.

viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antibiotics overuse Elderly PCR multiplex Viral infections

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could stopping antibiotics early help elderly virus patients?

What the study statuses mean