Case Comprehensive Cancer Center

This study tests whether removing only the cancerous part of the bladder (partial cystectomy) plus nearby lymph nodes works as well as removing the whole bladder for muscle-invasive bladder cancer. About 40 adults with early-stage cancer that hasn't spread will get standard chemo…

This study tests if kidneys that have a small tumor can be safely donated and repaired outside the body, then transplanted into people with kidney failure. The goal is to increase the number of available donor kidneys. The study will check for serious side effects within 30 days …

This study tests a new two-drug combination (trifluridine/tipiracil pills plus oxaliplatin IV) in 27 people with advanced biliary tract cancer whose first chemotherapy stopped working or didn't help. The goal is to see if this combo can keep the cancer from growing better than th…

This study tests whether a short course of antibiotics (metronidazole) and mouthwash (chlorhexidine) can lower the amount of bacteria living inside oral cancer tumors. About 30 adults scheduled for oral cancer surgery will receive the treatment before their operation. Researchers…

This study tests methimazole, a drug normally used for thyroid conditions, in people with progressive glioblastoma (a fast-growing brain cancer). The goal is to see if it can slow tumor growth and improve survival. About 19 participants will receive increasing doses to find the s…

This study tests whether using stem cells from both a half-matched family donor and a cord blood donor can improve survival for people with high-risk blood cancers like leukemia or myelodysplastic syndromes. About 36 participants will receive the transplant and be followed for up…

This early-phase study tests the safety of adding disulfiram (a drug used for alcoholism) and copper to a standard chemotherapy for sarcomas that have returned or not responded to prior treatment. About 24 adults with relapsed or refractory sarcoma will receive the combination. T…

This study tests if adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with colorectal cancer that has spread to the liver. About 100 adults whose liver tumors cannot be removed by surgery will receive both treatments. The goal …

This study is for people whose breast cancer has come back after previous breast-conserving surgery and whole breast radiation. The standard treatment after a second surgery is radiation twice a day for 30 sessions. This trial tests if giving radiation once a day for 15 sessions …

This study tests whether giving focused radiation (radiosurgery) before surgically removing brain tumors can prevent them from coming back. About 36 adults with 1 to 4 brain tumors will receive radiation directly to the tumor, followed by surgery. Researchers will also monitor si…

This study compares two modern treatments for men with low-to-intermediate risk prostate cancer that hasn't spread: a robotic partial prostatectomy (removing part of the prostate through a single port) and high-intensity focused ultrasound (HIFU, which uses sound waves to destroy…

This study looks at whether giving radiation therapy to areas where prostate cancer has spread (called metastasis-directed radiotherapy) can help control the disease better than the usual treatment. About 200 men with newly diagnosed prostate cancer that has spread will receive h…

This study tests whether a vitamin B3 supplement called nicotinamide riboside (NR) is safe and tolerable for 20 people receiving a bone marrow transplant. The goal is to see if NR can help donor blood stem cells grow faster and reduce recovery time. Participants will take NR pill…

This study tests whether sitagliptin, a diabetes drug, can help the immune system fight glioblastoma, an aggressive brain tumor. About 48 adults with progressive grade 4 glioma will receive sitagliptin before surgery to see if it increases cancer-fighting immune cells in the tumo…

This study looks at 1,000 adults aged 40-80 who have lost weight without trying. Participants will weigh themselves weekly using a smart scale. If they lose 5% or more of their body weight, they will get a special blood test (GRAIL Galleri) that can spot many types of cancer earl…

This study aims to see if a new office-based test can detect Barrett's esophagus—a condition that can lead to esophageal cancer—in people who do not have chronic heartburn. About 800 adults will answer a questionnaire, swallow a capsule balloon to collect cells, and have a lab te…

This study looks at whether a stool test that checks for certain DNA markers can find polyps or cancer in people who have already had colorectal cancer. About 50 adults with stage I to III colon or rectal cancer will take the stool test and then have a colonoscopy to compare resu…

This study tests a faster MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can clearly tell the difference between a brain tumor coming back and brain damage from radiation therapy. About 90 people will join, including healthy volunteers, people with new …

This study tests different ways to help Black or African American men aged 40 and older get screened for prostate cancer. Participants will receive either passive navigation, active navigation, or community-based screening to see which method works best. The goal is to increase t…

This study tests whether a supervised exercise and breathing program (pulmonary rehabilitation) can improve shortness of breath and quality of life in people with advanced non-small cell lung cancer. Half of the 85 participants will receive 8 weeks of rehab, while the other half …

This study is for people whose cancer has spread to up to 5 spots (oligometastatic) and who need stereotactic body radiation therapy (SBRT). Normally, planning SBRT takes a week or more because a special CT scan is needed. This study tests whether using the scans patients already…

This study tests whether starting a tongue strengthening exercise program soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who have part of their tongue removed will use a biofeedback device called the Tongueometer to do the exercises. The goal …

This study looks at whether timed fasting (not eating for 16 hours a day, 5 days a week) is safe and doable for women with advanced ovarian cancer receiving chemotherapy before surgery. About 20 participants will either follow a fasting schedule or standard diet for 6-9 weeks. Re…

This study tests a device called Scrambler Therapy to see if it can reduce pain, numbness, and tingling caused by chemotherapy. About 90 adults with nerve pain lasting at least three months will receive either real or sham treatment for 10 sessions. The goal is to improve daily a…

This study tests a new, faster method to deliver radiation therapy for severe abdominal pain caused by pancreatic cancer. Normally, planning this treatment takes over a week because a special CT scan is needed. Here, doctors will use the patient's existing diagnostic CT scan to p…

This study tests whether giving spine radiation in one session or two sessions better prevents bone fractures in people with cancer that has spread to the spine. About 130 adults with spine tumors will receive either one or two focused radiation treatments. The main goal is to se…

This study looks at whether a program of exercise and nutrition (called prehabilitation) can help people aged 65 and older with advanced ovarian or pancreatic cancer get ready for surgery while they receive chemotherapy. The main goal is to see if participants can stick with the …

This study tests whether an artificial intelligence (AI) app can improve quality of life and reduce anxiety and depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the AI app alongside their usual…

This study tests a wearable smart patch that continuously tracks vital signs and glucose levels in 30 cancer patients receiving chemotherapy or immunotherapy. The goal is to detect side effects like febrile neutropenia sooner, so treatment can be adjusted quickly. Participants we…

This study tests a program that uses a patient navigator to help racial and ethnic minority cancer patients learn about clinical trials. The goal is to improve their knowledge and attitudes so they can make better decisions about joining trials. About 240 adults with cancer who a…

This study looks at whether artificial intelligence (AI) can help radiologists find prostate cancer on MRI scans. About 150 men aged 55-80 who are scheduled for a prostate biopsy will take part. Doctors will compare how well they detect cancer with and without AI assistance. The …

This study looks at whether removing lymph nodes during surgery for upper tract urothelial cancer helps prevent the cancer from coming back. About 94 adults with this cancer will be randomly assigned to have standard surgery with or without lymph node removal. Researchers will tr…

This study looks at two methods for removing breast cancer in women with early-stage disease. One method removes extra tissue around the tumor routinely, while the other uses a special marker to remove tissue only where needed. The goal is to see which approach leads to fewer can…

This study looks at how different Mediterranean-style diets affect the body's metabolism in men with early-stage prostate cancer who are not yet receiving treatment. Researchers will provide specific meals to 30 men and measure changes in their prostate tissue and blood. The goal…

This study looks at whether a special MRI scan taken before robotic surgery can help doctors predict if all the cancer will be removed. It involves 30 adults with HPV-positive tonsil cancer who are scheduled for transoral robotic surgery. The MRI will measure the thickness of a m…

This study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small biopsies at recording sites and follow patients with MRI scans to see if brain activity patterns can predict where the tumor w…

This study looks at whether chemicals from the 2023 train derailment in East Palestine, Ohio, caused DNA damage in local residents. About 500 people who lived nearby at the time will give blood, spit, hair, or nail samples and answer a survey. The goal is to link where people liv…

This study creates a database of patients who receive proton beam therapy at University Hospitals. Researchers will track their progress to see how well the treatment works. Anyone treated with proton therapy at the center can join. The goal is to learn more about long-term outco…

This study looks at whether it is safe to skip placing a drain in the belly after surgery to remove the tail of the pancreas. The goal is to see if avoiding drains leads to fewer serious problems like infections or leaks. About 234 adults having this surgery will be randomly assi…

This study is testing whether a probiotic supplement called BIOHM can change the bacteria and fungi living in the breast tumors and guts of 100 women with breast cancer. The goal is to understand how these tiny organisms might affect cancer development. Participants will take eit…

This study looks at how photodynamic therapy (PDT) changes the immune system's reaction to basal cell carcinoma (BCC), a common skin cancer. Researchers will analyze tumor and blood samples from 28 adults scheduled for surgery to understand immune cell activity. The goal is to fi…

This study tests whether a smartwatch can track changes in walking and daily activities in 60 people with bone cancer (osteosarcoma or metastatic bone disease) in the legs or pelvis. Participants wear the watch at least 12 hours a day and complete weekly questionnaires for 12 wee…

This study aims to discover new gene mutations that may cause cancer by analyzing DNA from 150 adults who either have cancer or have a strong family history of cancer, especially families with five or more different types of cancer. Participants provide a blood sample for genetic…

This study looks at how the collection of bacteria, fungi, and viruses in the vagina changes in women who receive a stem cell transplant. Researchers want to learn why some women develop a painful condition called vulvovaginal graft-versus-host disease (GVHD). About 40 women will…

This study tests a new way to help people with cancer, especially those from African American, Hispanic, or underserved areas. The program provides extra support and resources to reduce distress and improve quality of life. About 375 adults with suspicious cancer findings or a ca…