Case Comprehensive Cancer Center

This early-phase study tests the safety of adding the drug ibrutinib to standard radiation and chemotherapy for people with a fast-growing brain cancer called glioblastoma. About 36 participants will receive different doses to find the safest amount. The goal is to control the di…

This early-phase study tested adding low-dose internal radiation (brachytherapy) to standard immunotherapy for people with advanced melanoma, kidney cancer, or urinary tract cancer. Only 5 participants were enrolled to see if the combination helps shrink tumors. The goal was to m…

This early-phase trial tests a drug called ivosidenib combined with standard chemotherapy in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the combination shrinks tumors before surgery. Up to 16 participants will take…

This early-phase study tests whether adding the experimental drug ruxolitinib to standard brain cancer treatment (radiation and temozolomide) is safe and tolerable for people with newly diagnosed high-grade gliomas or glioblastoma. About 60 participants will receive the combinati…

This study aimed to test a new experimental drug called BC3402 combined with two other immunotherapy drugs (tremelimumab and durvalumab) for people with advanced liver cancer that cannot be removed by surgery. The goal was to see if the combination was safe and effective at shrin…

This study was designed to see if surgeons could safely perform robotic surgery on prostate cancer patients from a remote location. It planned to enroll adults needing robotic prostate procedures. However, the trial was withdrawn before any participants were enrolled, so no resul…

This study tests a new approach for adults with recurrent glioblastoma, an aggressive brain cancer. It combines a minimally invasive laser that heats and destroys tumor tissue (LITT) with pembrolizumab, an immunotherapy drug that helps the immune system fight cancer. The goal is …

This study tests a new MRI technique called magnetic resonance fingerprinting (MRF) to improve how brain tumors are diagnosed and assessed. Researchers will compare MRF data with standard tests, treatment details, and biopsy results in 172 people with brain tumors. The goal is to…

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The program is designed with community input t…

This study looks at whether adding personalized exercise therapy to standard radiation therapy helps men with metastatic prostate cancer feel better and function physically. About 80 men receiving radiation will either get exercise coaching or not. Researchers will measure qualit…

This study works with Spanish-speaking Latiné men who have had prostate cancer surgery. Researchers want to learn about their quality of life and decision-making challenges, especially around issues like erectile dysfunction. The goal is to create better educational videos and re…

This study aimed to create a better way to teach family caregivers how to care for a loved one with a tracheostomy after head and neck cancer surgery. The goal was to help caregivers feel more confident and prepared for discharge. However, the study was withdrawn before any parti…

This study aims to understand how much information people can remember about their own cancer screening and diagnosis. Researchers will test whether giving extra time or resources helps people recall more accurate details. The study was withdrawn before enrolling any participants…

This study looks at whether a special, quick brain MRI (called magnetic resonance fingerprinting) can detect changes in the brains of children and young adults (ages 0-30) with acute leukemia who are receiving chemotherapy. Participants will have brain scans and take a fun, game-…

This study explores whether an Apple Watch can detect changes in walking, heart rate, breathing, and sleep in people with glioblastoma. Researchers aim to use this data to predict complications like seizures or blood clots before they happen. The study involves 25 adults with new…

This study looks at the DNA of people with rare blood diseases like Castleman disease and histiocytosis. The goal is to find genetic changes that could be targeted with existing or new treatments. About 135 participants will provide samples for genetic testing. The study is curre…

This study explores whether personalized treatment recommendations based on lab tests of a patient's own tumor can be made within 4 weeks for adults with relapsed or refractory cancers who have no standard curative options. Researchers will use drug sensitivity testing and geneti…