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Experimental combo aims to boost immune attack on head and neck tumors

NCT ID NCT07216833

Not yet recruiting Disease control Sponsor: Kyunghee Burkitt, DO, PhD Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 31 times

Summary

This early-stage study tests a combination of two drugs—decitabine (a chemotherapy that can reactivate genes) and nivolumab (an immunotherapy that helps the immune system fight cancer)—in people with advanced head and neck cancer that has come back or spread. About 15 participants will receive the treatment to find the safest dose and see if the drugs can boost the body's immune response against tumors. The goal is to control the disease, not cure it, and participants will be monitored closely for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute

    Cleveland, Ohio, 44195, United States

    Contact

    Contact

Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER HEAD AND NECK NEOPLASMS HEAD AND NECK SQUAMOUS CELL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA