Baylor College Of Medicine

This study is testing a treatment guideline designed for children with acute myeloid leukemia (AML) in Malawi, where resources are limited. It will enroll 30 children under 18 to see if the adapted plan is both feasible and effective at achieving remission. The goal is to improve…

This study tests a new way to make immune cells (T cells) that can attack cancer cells infected with the Epstein-Barr virus (EBV). The cells are grown faster in the lab and given to patients with Hodgkin or non-Hodgkin lymphoma, or related diseases that have come back or not gone…

This study tests a new treatment for children with neuroblastoma that has come back or not responded to standard therapy. Researchers take the child's own immune cells (called NKT cells), add a special receptor to help them recognize and attack the cancer, and also add a molecule…

This early-stage study tests a new approach for people with certain lymphomas (like Hodgkin lymphoma) that have come back or not responded to standard treatments. Researchers take immune cells from healthy donors, add a special receptor (C7R) to help them survive longer, and targ…

This study tests a new treatment for people with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not gone away. The treatment uses the patient's own T-cells, which are modified with a gene called C7R to help them live longer and better attack cancer cells. The m…

This early-phase trial tests a new type of immunotherapy for adults with solid tumors that have a protein called GPC3 on their surface. Researchers take a patient's own T cells, add genes to help them recognize and attack GPC3-positive cancer cells, and also include a safety swit…

This study tests a program that helps kids aged 10-13 with type 1 diabetes and their parents find and build on the child's strengths. The goal is to improve blood sugar control, daily diabetes care, and quality of life. The program involves youth, parents, and diabetes care provi…

This study tests a new treatment for people with brain tumors that have a protein called GD2. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack the tumor. A special gene is added to help these cells survive longer in th…

This study tests a newer pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a wide QRS or high pacing need. The goal is to see which approach better improves quality of life, reduces hosp…

This study tests whether growth hormone replacement therapy is safe and effective for veterans with Gulf War Illness who also have a growth hormone deficiency. About 20 veterans will receive the hormone for 6 months, and researchers will measure changes in belly fat, symptoms, an…

This study tests whether a combination of immunotherapy drugs (durvalumab and tremelimumab) alone or with chemotherapy can help people with a type of lung cancer called pleural mesothelioma that can be removed with surgery. The goal is to see if these treatments can keep the canc…

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and hard-to-treat fluid buildup (ascites) can reduce the need for frequent fluid drainage procedures. About 100 adults with cirrhosis and refractory ascites will receive e…

This early-phase study tests a new treatment for people with T-cell leukemia or lymphoma that has come back. Doctors take a patient's (or their donor's) immune cells, add a special receptor that helps them recognize and attack cancer cells, and give them back. The goal is to see …

This early-phase trial tests a new treatment called CARE T cells for children whose solid tumors (like liver cancer or Wilms tumor) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding special genes to help them recog…

This study tests a new immune therapy for people with advanced B-cell lymphoma or leukemia that has returned or not responded to standard treatment. Researchers take a patient's own T-cells, add a special receptor (CAR) that targets the CD19 protein on cancer cells, and give them…

This early-phase study tests a new therapy using a patient's own immune cells (T cells) trained to attack proteins found on myeloma cells. It includes adults with active multiple myeloma or high-risk precursor conditions (MGUS or smoldering myeloma). The main goals are to find a …

This study tests whether a single chemotherapy drug, cytarabine, works better than the usual two-drug combination (vinblastine/prednisone) for treating Langerhans cell histiocytosis (LCH), a rare cancer that causes tissue damage. About 124 children and young adults up to age 21 w…

This early-stage trial tests a new treatment for people with T-cell leukemia or lymphoma that has come back or not responded to standard therapy. Doctors take a patient's own immune cells (T cells), modify them in the lab to recognize and attack cancer cells carrying the CD7 prot…

This early-phase study tests a new treatment for people with T-cell leukemia or lymphoma that has come back. The treatment uses the patient's own immune cells (T cells) that have been modified in a lab to recognize and attack cancer cells carrying a protein called CD7. The goal i…

This study tests if a special surgery before birth can safely repair a severe birth defect called complex gastroschisis, where the baby's intestines grow outside the belly. Ten pregnant women will receive a fetoscopic procedure to put the intestines back inside and close the skin…

This early-stage study is testing whether a new type of immune cell therapy, called HER2-CAR T cells, combined with drugs that boost the immune system (pembrolizumab or nivolumab), is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy before th…

This study is for people who need a stem cell transplant but only have a half-matched donor, like a parent or child. The goal is to reduce the risk of graft-versus-host disease (GvHD), where donor cells attack the patient's body. Researchers will use a device to select only the C…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This early-phase trial tests a new treatment for adults with a returning type of brain cancer called glioblastoma. The treatment uses the patient's own immune cells (T cells) that are genetically modified in a lab to recognize and attack cancer cells that carry a specific protein…

This study looks at how safe and effective custom-made stents are for treating complex bulges or tears in the main artery (aorta). About 760 people with large or fast-growing aneurysms will receive these special stents. Researchers will track deaths, major complications like hear…

This study tests a mobile, AI-powered microscope that helps doctors spot early signs of esophageal cancer during a routine scope exam. About 200 adults in Brazil and the United States will take part. The goal is to see if the AI tool makes diagnosis more accurate and reduces the …

This small study tests whether a steroid cream applied to the penis can prevent repeat urinary tract infections (UTIs) in uncircumcised baby boys under 6 months old who have already had one UTI. Half the babies get the steroid cream, half get a placebo cream, applied twice a week…

This study is testing a mobile health app to help Hispanic teenagers (ages 12-18) who are overweight improve their diet, physical activity, and sleep. The goal is to see if the app is easy to use and can help prevent type 2 diabetes. Thirty participants will use the app for 30 da…

This study tests if giving parents food prescriptions along with tips on best feeding practices can help prevent chronic diseases like obesity in children. Researchers will work with 375 parents of 4-8 year olds in Texas. The goal is to see if this approach is practical and well-…

This study tests a new device called Pathfinder that stiffens the scope during colon tumor removal. The goal is to see if it makes the procedure faster and safer than the usual method. About 66 adults with certain colon growths will take part. If it works, patients may have short…

This study compares two ways to remove abnormal growths from the colon: standard endoscopic surgery (ESD) versus using a special traction device that pulls the growth for better access. Researchers want to see if the device makes the procedure faster and reduces complications. Ab…

This study tests two fast-paced versions of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format better redu…

This study tests a special support program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The goal is to see if this program can improve quality of life and reduce depression compared to usual care. The study will involve 120 women and …

This study tests a new type of knife that uses bipolar radiofrequency energy to remove precancerous growths from the esophagus. About 50 adults will take part to see if the tool works well and is safe. The goal is to make the procedure faster and reduce the risk of injury.

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce PTSD symptoms in US Veterans. Fifteen participants will receive two guided psilocybin sessions. The goal is to see if this approach is safe and helps ease t…

This study looks at how safe and effective a special device called Speedboat UltraSlim™ is when used during a surgery called POEM to treat swallowing problems like achalasia. About 40 adults who are already scheduled for this surgery will have their medical records reviewed. The …

This pilot study tests whether combining two non-invasive brain stimulation methods—iTBS and tDCS—can safely ease neuropsychiatric symptoms like mood swings, apathy, and agitation in people with Alzheimer's disease. Twenty veterans aged 60-85 with mild to moderate Alzheimer's wil…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study tests whether daily exposure to bright light can help reduce fatigue and improve thinking skills in children and teens who have been treated for a brain tumor. The study involves 40 participants who will use a light box at home for 6 weeks. The goal is to see if this a…

This study tests a new wireless, bandage-like sensor called FlowSense that measures fluid flow in the brain for people with hydrocephalus. The sensor is placed on the neck to check if a shunt is working without needing X-rays or hospital equipment. Researchers will compare its re…

This study is trying to find the specific gene that causes Aicardi syndrome, a rare brain disorder. Researchers are collecting blood and skin samples from up to 500 people with the condition and their parents to analyze their DNA. The goal is to identify genetic changes unique to…

This research study aims to learn more about the physical traits and genetic changes linked to microphthalmia, anophthalmia, and coloboma (MAC) in children. Researchers will collect medical histories, saliva, and blood samples, and perform detailed exams including eye tests and b…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a support program to help patients complete TB prevention treatment. The goal is to reduce TB deaths, …

This study gathers information from 500 children with severe, early-onset obesity to learn which genes may be involved. Researchers will look at genetic test results and track body mass index over time. No treatment or intervention is given—this is purely an observational databas…

This study aims to help families with food insecurity and mothers with depression. Researchers will provide resources like food, rent help, and mental health support to see if it improves the bond between mother and child. The study includes 2,000 caregivers of young children in …

This study aims to understand how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers will use special electrodes placed inside the brain to record activity while participants perform mood-related tasks. The …

This study looks at how the amino acid arginine works in the bodies of young people with type 2 diabetes. Researchers will compare 30 teens with diabetes to healthy teens to see if arginine affects insulin release. The goal is to learn more about the disease and test if arginine …

This study offers advanced genetic testing and virtual doctor consultations for seriously ill newborns in Texas hospitals with limited resources, especially near the Texas-Mexico border. Researchers will test a tool called Consultagene to see if it helps doctors diagnose rare gen…

This study aims to see if a standard prenatal care plan helps babies with a blocked bladder (LUTO) survive and have better kidney function. Researchers will track 50 pregnant women and their babies from diagnosis to 24 months after birth. The goal is to improve outcomes by follow…

This study looks at how two different doses of a sedative called dexmedetomidine change the amount of anesthesia (sevoflurane) needed to prevent movement during surgery in children aged 1 month to 3 years. About 180 children will take part. The goal is to find the right dose to s…

This study compares two ways surgeons enter the uterus during laser surgery for twin-to-twin transfusion syndrome. It aims to see if one method causes less separation of the membranes around the babies. About 216 pregnant women between 16 and 26 weeks will take part. The results …

This study aims to better understand how brain activity relates to mood in people with depression and epilepsy. Researchers will use precise brain recordings and artificial intelligence to analyze mood changes. The goal is to improve treatments for depression and other mental hea…

This study tests whether a short animated video and a picture guide can help patients give a cleaner urine sample, leading to fewer false-positive results and less unnecessary antibiotic use. About 252 adults in primary care clinics will either watch the video and get the guide o…

This study gathers health information and biological samples from 300 people with TANGO2 deficiency, a rare genetic condition. Researchers will track hospitalizations for metabolic and cardiac crises to understand how the disease progresses. The goal is to create a database and b…

This study offers genome sequencing to 25 newborns diagnosed with HIE (a severe brain condition from lack of oxygen at birth) who are undergoing cooling therapy. Researchers want to find out how often genetic changes cause or contribute to HIE. The goal is to learn which babies m…

This study gives healthy adults different doses of hookworm larvae through the skin to find a safe dose that causes a consistent infection. The goal is to create a reliable model for testing a future hookworm vaccine. About 35 people aged 18 to 45 will take part for 6 months.

This study looks at healthy infants and toddlers to see how the fruits and vegetables they eat affect their skin and eyesight. Researchers will measure carotenoid levels in the skin and blood, and test vision over 6 visits from 4 to 24 months old. No treatment is given—only obser…