Baylor College Of Medicine

This early-phase study tests a new therapy using a patient's own immune cells (T cells) trained to attack proteins found on myeloma cells. It includes people with active multiple myeloma or high-risk precursor conditions (MGUS or smoldering myeloma). The main goals are to find a …

This early-stage study tests a new type of cell therapy for people with certain lymphomas that have come back or not responded to treatment. The therapy uses immune cells from healthy donors that are modified to better recognize and attack cancer cells, plus an added molecule to …

This early-phase trial tests a new cell therapy for people with T-cell leukemia or lymphoma that has come back or not responded to treatment. Researchers take a patient's own T-cells, add a special receptor (CD7.CAR) to help them recognize and attack cancer cells, and give them b…

This early-phase study tests a new gene therapy for people with aggressive brain tumors that have a protein called GD2. Researchers take a patient's own T cells, add a special receptor to help them recognize and attack GD2 on cancer cells, plus a gene that helps the T cells live …

This study tests a new treatment for children with neuroblastoma that has come back or not responded to standard therapy. Doctors take the child's own immune cells (called NKT cells), add a special receptor to help them find and kill cancer cells, and give them back along with a …

This study tests a new way to make special immune cells (T cells) that can attack cancer cells infected with the Epstein-Barr virus (EBV). The cells are grown faster in the lab and given to patients with Hodgkin or non-Hodgkin lymphoma, or related diseases that have come back or …

This study tests whether a combination of two immunotherapy drugs (durvalumab and tremelimumab) works better with or without chemotherapy for people with pleural mesothelioma that can be surgically removed. The goal is to see if these treatments can keep the cancer from returning…

This early-phase study tests a new type of immunotherapy for people with advanced B-cell lymphoma or leukemia that has returned or not responded to standard treatment. Researchers take a patient's own T-cells (a type of immune cell), add a special receptor that targets a protein …

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This study looks at how safe and effective custom-made stents are for treating complex bulges or tears in the main artery (aorta). About 760 people with large or fast-growing aneurysms will receive these special stents. Researchers will track deaths, major complications like hear…

This early-phase study tests a new type of immunotherapy for adults with solid tumors that have a specific marker called GPC3. The treatment involves taking a patient's own T cells, adding genes to help them recognize and attack cancer cells, and then giving them back. The study …

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and severe fluid buildup (ascites) can reduce the need for frequent fluid drainage procedures. About 100 adults with hard-to-treat ascites will receive either standard or …

This study tests a standard care plan for unborn babies diagnosed with lower urinary tract obstruction (LUTO), a condition where urine flow is blocked. Researchers will follow 50 pregnant women and their babies to see if this approach improves survival and kidney function up to 2…

This study is for people who need a stem cell transplant but don't have a perfectly matched donor. Instead, they can use a half-matched relative's stem cells. To lower the risk of a serious complication called graft-versus-host disease (where donor cells attack the patient), the …

This study is testing a new, portable microscope that uses artificial intelligence to help doctors spot early signs of esophageal cancer. About 200 adults in Brazil and the United States who are already scheduled for a routine screening procedure will also be examined with this d…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely reduce PTSD symptoms in US Veterans. Fifteen participants will receive two guided sessions plus psychotherapy. The goal is to measure safety and symptom improvement, no…

This study tests a new type of knife that uses bipolar radiofrequency energy to remove precancerous growths from the esophagus. The goal is to see if this tool is safe, effective, and faster than current methods. About 50 adults with certain precancerous lesions in the upper esop…

This pilot study tests a non-invasive ear stimulation method (taVNS) to see if it can improve attention and memory in veterans with traumatic brain injury (TBI), depression, or PTSD. Thirty veterans will each receive both active and sham stimulation in one visit while performing …

This pilot study tests a combination of two non-invasive brain stimulation methods—iTBS and tDCS—in 20 older veterans with mild to moderate Alzheimer's disease who also have mood or behavior symptoms like agitation or apathy. Participants will receive one week of in-clinic iTBS s…

This study compares two intensive formats of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format best reduc…

This study looks at how surgeons enter the uterus during laser surgery for twin-to-twin transfusion syndrome. It aims to see if different entry techniques affect the chance of the membrane separating from the uterine wall. About 216 pregnant women between 16 and 26 weeks will tak…

This study aims to learn how genetic changes contribute to microphthalmia, anophthalmia, and coloboma (MAC) in children. Researchers will collect medical histories, conduct physical exams, and analyze DNA from saliva or blood samples. Up to 3,000 children and their family members…

This study looks at how the body processes arginine, a natural nutrient, in teenagers and young adults with type 2 diabetes. Researchers will compare 30 youth with diabetes to healthy controls using safe, minimally invasive tests. The goal is to understand the disease better and …

This study collects health information and biological samples from 300 people with TANGO2 deficiency, a rare genetic condition. Researchers will track hospitalizations and other health events to better understand how the disease progresses. The goal is to build a database and sam…

This study looks at how two different doses of dexmedetomidine, a sedative, affect the amount of sevoflurane (an inhaled anesthetic) needed to prevent movement during surgery in children aged 1 month to 3 years. Researchers will enroll 180 children and check their response to a s…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a blood test to improve TB detection. They will also compare different support methods to help patient…