Baylor College Of Medicine

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. The goal is to see if carnitine can improve arte…

This early-phase study tests a new treatment for people with HER2-positive brain tumors that have come back or not responded to standard care. The treatment involves taking a patient's own immune cells (T cells), adding a special antibody (HER2-CAR) to help them recognize and att…

This early-phase study tests a new cell therapy for patients with relapsed EBV-positive lymphoma. The treatment uses the patient's own immune cells, modified to resist a tumor's defense mechanism (TGFb) and trained to attack cancer cells. The main goals are to find a safe dose an…

This early-phase study tests a new therapy using donor immune cells trained to recognize four proteins found on AML and MDS cancer cells. The cells are given to patients at least 30 days after a stem cell transplant. The main goal is to find the safest dose and see if the cells c…

This study tests a new treatment for people with advanced sarcoma, a type of cancer. Researchers take the patient's own immune cells (T cells) and add a new gene to help them recognize and attack cancer cells that have a protein called HER2. Before the cells are given back, some …

This early-phase study tests a new treatment for people with certain blood cancers (lymphoma or leukemia) that have returned after a stem cell transplant. Researchers take immune cells (T cells) from the original stem cell donor, modify them to recognize and attack cancer cells c…

This study was designed to test whether adding a drug called 5-azacytidine (AZA) to standard steroid treatment is safe and feasible for people with gut graft-versus-host disease (GVHD) after a stem cell transplant. GVHD occurs when donor cells attack the patient's body, and gut i…

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This study looks at whether people with chronic myeloid leukemia (CML) who have had a very low level of cancer for at least two years can safely stop taking their daily targeted therapy (TKI). Seventeen adults who have been on TKI for over three years will stop their medication a…

This study tests a new treatment for adults with acute myeloid leukemia (AML) that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in the lab to recognize and attack AML cells carrying a protein call…

This early-stage study tests a new cell therapy called ANCHOR cells for people with B-cell lymphoma or leukemia that has returned or not responded to standard treatments. The cells are made from a healthy donor's immune cells and are modified to better recognize and attack cancer…

This early-phase study tests a new treatment called GAP T cells for children and young adults with a type of liver cancer that has returned or not responded to standard therapy. The treatment involves taking a patient's own immune cells, adding a gene to help them recognize and a…

This study tests whether specially trained immune cells from healthy donors can safely fight cancers and diseases caused by the Epstein-Barr virus (EBV). The cells are made quickly in the lab and stored in a bank, so they are ready for patients whose cancer has returned or not re…

This early-phase study tests a new treatment called CATCH T cells for people with certain solid tumors (like liver cancer) that have come back or not responded to standard care. The treatment involves taking a patient's own immune cells, adding special genes to help them recogniz…

This early-stage study tests a new immune cell therapy for people with a type of throat cancer linked to the Epstein-Barr virus. Researchers take the patient's own T cells, train them to recognize the virus on cancer cells, and add a gene to make them resist a chemical that tumor…

This study tests a stem cell transplant method that filters out certain immune cells (TCRαβ+ and CD19+) from a half-matched family donor's blood. The goal is to lower the risk of graft-versus-host disease, a serious complication, and allow patients to avoid long-term immune-suppr…

This early-phase study tests a new way to fight Hodgkin and non-Hodgkin lymphoma that has returned or not responded to standard treatment. Researchers take a patient's own immune cells (T cells), add a special receptor that targets the CD30 protein on lymphoma cells, and also tra…

This early-stage trial tests a new treatment called AGAR T cells for children whose solid tumors (like liver cancer or rhabdomyosarcoma) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding genes to help them recogniz…

This early-phase study tests a new treatment for advanced osteosarcoma and neuroblastoma that has not responded to standard therapies. The approach uses a patient's own immune cells (T cells) that are genetically modified to recognize and attack cancer cells carrying a protein ca…

This study tests whether a weight loss program called "Paso a Paso" is practical for 50 Mexican and Central American adults with fatty liver disease and overweight. Researchers will check if participants attend enough sessions and if the program helps with weight loss, liver heal…

This study tests a video-based program called VITAL Start for Adolescents to help teens living with HIV take their medicine regularly and keep the virus under control. About 1,800 teens and their caregivers in Malawi will either watch the videos plus get standard care, or just st…

This early-phase study tests a new approach for people with B-cell lymphoma or leukemia that has returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells), modify them in the lab to recognize and attack cancer cells carrying the CD19 p…

This early-phase study tests a new gene therapy for children with neuroblastoma that has come back or not responded to treatment. The therapy uses the patient's own immune cells (T cells) that are modified in the lab to recognize and attack neuroblastoma cells. The study aims to …

This study is testing a new device that uses ultrasound to look inside the ear and help doctors diagnose middle ear infections more accurately. About 300 children scheduled for ear tube surgery will have their ears examined with the prototype device. The goal is to collect data t…

This study tests a program called 'Healthy Dads, Healthy Kids' adapted for Hispanic families. It aims to help fathers lose weight and increase their children's physical activity to prevent obesity. About 187 fathers and their children (ages 5-11) from the Houston area are taking …

This study looks at whether mailing self-sampling HPV test kits to Asian and Asian American women who are behind on screening can help them get tested for cervical cancer. About 111 women in Houston, Texas, who haven't had a Pap test in years will receive a kit to collect their o…

This study planned to test whether adding ear acupuncture during surgery to repair a broken lower leg could help patients use fewer opioid painkillers afterward. It was designed for adults aged 18–64 having ankle or foot fracture surgery. However, the study was withdrawn before e…

This study tests whether Invisalign clear aligners can safely and effectively straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and teeth fragile. Traditional braces can be risky for OI patients, so researchers are evaluating a les…

This study planned to test whether giving ear acupuncture during wrist surgery could lower the amount of opioid painkillers patients need afterward. It was designed for adults aged 18-64 having a specific type of wrist fracture repair. However, the study was withdrawn before any …

This study compares two family-based behavioral treatments delivered via telehealth for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD). The goal is to see if these lower-intensity therapies work as well as a relaxation and mentorship program. About 100 chi…

This study compares a new bipolar knife to a standard monopolar knife for removing colon growths during a procedure called endoscopic submucosal dissection (ESD). About 80 adults with colon growths will be randomly assigned to one knife. The goal is to see which knife works faste…

This study tests whether a non-invasive headband device called Cefaly, originally approved for migraines, can help reduce seizures in veterans with drug-resistant epilepsy. 24 veterans will take part, with half using the device plus standard care and half receiving standard care …

This study compares two different knives used during a procedure called POEM, which helps people with swallowing disorders like achalasia. The goal is to see if a newer bipolar knife causes less pain after surgery and requires fewer tool changes than the standard monopolar knife.…

This study aims to help mothers of babies in the hospital cope with depression and anxiety while strengthening their bond with their baby. It also connects families to resources for food, housing, and other household needs. About 200 English- or Spanish-speaking caregivers of inf…

This study tests whether a series of short educational videos for parents can help them better support their adolescent child with anorexia or atypical anorexia. About 50 parent-teen pairs will take part. Parents who watch the videos alongside standard treatment will be compared …

This study looks at whether testing men for HPV antibodies or HPV DNA in their blood can help find throat and anal cancers early. Researchers will follow 1,500 men who test positive for these markers to see how many develop cancer. The goal is to improve screening and catch these…

This study looks at whether a brief home visitation program, delivered by non-nurse visitors, can help pregnant and postpartum women connect to community resources, feel more confident about their health, and reduce stress. About 450 women will be randomly assigned to either rece…

This study looks at whether chewing xylitol gum during pregnancy can change the bacteria in the mouth and vagina, reduce gum inflammation, and improve pregnancy outcomes. Researchers in Malawi will follow 80 pregnant women and their babies to check gum health, pregnancy complicat…

This study looks at whether increasing glutathione, a natural antioxidant in the body, can improve thinking and memory in older adults with mild cognitive impairment. Sixty participants will take either glutathione-boosting supplements or a placebo for 12 weeks, then stop for ano…

This study tests if giving small amounts of breast milk in the mouth (oral care) helps babies born with gastroschisis, a rare hole in the belly wall, tolerate feedings and avoid infections. Researchers will compare babies who get breast milk oral care to those who get sterile wat…

This study is testing whether a urine sample can be used to identify different genetic types of osteogenesis imperfecta (OI), a rare condition that makes bones break easily. Researchers will measure specific collagen breakdown products in the urine of 25 people with OI and compar…

This study looks at how osteogenesis imperfecta (brittle bone disease) affects the lungs and heart. Researchers will measure lung function and use CT scans in 18 adults to find out why breathing problems are common. The goal is to better understand the disease, not to test a new …

This study aims to find the genetic changes that cause recurrent hydatidiform moles, a rare type of pregnancy where tissue grows abnormally in the womb. Researchers will analyze DNA from up to 100 women with a personal or family history of these moles, as well as some relatives. …

This study follows about 51 premature babies (born before 37 weeks and weighing 2.75 pounds or less) who were fed donor human milk while in the NICU. Researchers want to see how these infants grow and develop after they go home. The goal is to learn whether an exclusive human mil…

This study looks at dental and skull problems in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans to measure teeth misalignment and neck defects in 75 participants aged 10 and older. The go…

This study is for people with severe, hard-to-treat OCD. Researchers are testing an advanced brain stimulation system that can adapt to a person's needs. The goal is to find brain signals linked to OCD distress and improve how deep brain stimulation works. Only 2 people will take…

This study looks at how well noninvasive tests (like blood markers and special scans) can detect liver scarring in people with urea cycle disorders. About 62 participants aged 6 to 65 will undergo these tests at five medical centers. The goal is to find better ways to monitor liv…

This study aims to better understand the genetic causes of Goltz syndrome, a rare condition that affects skin, bones, eyes, and other organs. Researchers will collect blood samples from up to 84 participants and their parents to look for changes in the PORCN gene or other unknown…

This study is for people with severe, hard-to-treat obsessive-compulsive disorder (OCD). Researchers are testing a new type of deep brain stimulation that uses the brain's own signals to automatically adjust the electrical pulses. The goal is to improve symptom control and reduce…

This study follows up on premature babies (born weighing 2.2 pounds or less) who received either a standard or high-protein diet while in the NICU. Researchers want to see if the higher protein diet leads to better growth, body composition, and brain development at 18-24 months o…