Invisalign offers hope for safer smiles in brittle bone disease

NCT ID NCT04815564

Ongoing Symptom relief Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jan 05, 2026 · Last updated May 23, 2026 · Updated 21 times

Summary

This study tests whether Invisalign clear aligners can safely and effectively straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and teeth fragile. Traditional braces can be risky for OI patients, so researchers are evaluating a less invasive option. The study involves 57 participants aged 12 to 40 with mild to moderate dental misalignment. If successful, this approach could provide new guidelines for orthodontic care in OI.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

McGill University

Montreal, Quebec, H3A 1G1, Canada
Nidcr/Nih

Bethesda, Maryland, 20892-1470, United States
University of California Los Angeles

Los Angeles, California, 90095, United States

Conditions

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OSTEOGENESIS IMPERFECTA