Supercharged donor cells take aim at blood cancers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients will be eligible to receive donor-derived multiTAA-specific T cells following any type of allogeneic HSCT as; (i) Adjuvant therapy for AML/MDS (Group A) or (ii) Treatment for refractory/relapsed or minimal residual AML/MDS disease (Group B) Residual disease at the time of transplant or post transplant relapse is defined as PCR positivity, specific cytogenetic abnormalities, an abnormal population on flow cytometry or increased blasts on bone marrow biopsy, in the peripheral blood or any other extramedullary sites. Minimal residual disease (MRD) will be defined as detection in blood, bone marrow, or other tissues of any of the following: (i) Any leukemia specific marker such as t(8;21); inv 16; t (15;17), t(9;22) or t(4;11) documented in the patient's leukemia cells pre-transplant on a post-transplant evaluation. (ii) Expression of a leukemia associated antigen known to be a marker for residual disease like WT1. (iii) A leukemia-specific phenotype (e.g. expression of markers including CD13 and/or CD33 and/or CD117 and/or HLA-DR+) post-transplant at a level of ≥ 0.01%. (ix) Mixed donor chimerism (\> 20%). 2. Life expectancy ≥ 6 weeks. 3. Karnofsky/Lansky score of ≥ 50. 4. Patient or parent/guardian capable of providing informed consent. 5. Bilirubin ≤ 2X upper limit of normal. 6. AST ≤ 3X upper limit of normal. 7. Undergoing stem cell transplant at CAGT. 8. Serum creatinine ≤ 2X upper limit of normal. 9. Hgb ≥ 7.0 g/dL (can be transfused). 10. Pulse oximetry of \> 90% on room air. 11. Sexually active patients must be willing to utilize one of the more effective birth control methods for 6 months after the T cell infusion. Male partner should use a condom. 12. Available donor-derived multiTAA-specific T cell line. 13. No other investigational anti-neoplastic therapy for one month prior to entry in this study. Exclusion Criteria: 1. Patients receiving ATG or Campath within 28 days of infusion. 2. Patients receiving a Donor Lymphocyte Infusion within 4 weeks of planned T cell infusion. 3. Less than 30 days post-allogeneic stem cell transplant. 4. Severe intercurrent infection. 5. Evidence of GVHD \> Grade II. 6. Pregnant or lactating. 7. Currently taking corticosteroids (\> 0.5 mg/kg/day prednisone or equivalent).