PARKINSON'S DISEASE

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will enroll 56 adults with Parkinson's to see if targeting slow-wave sleep can help delay worsening of motor symptom…

This study looks at how well a drug called Foslevodopa/Foscarbidopa works for people with advanced Parkinson's disease in everyday medical practice in Belgium. About 120 adults will be followed for up to 18 months while receiving the drug as prescribed by their doctor. The main g…

This registry is collecting information from around the world on how well the Vercise deep brain stimulation (DBS) system works for people with Parkinson's disease. It will include up to 1,500 adults who are already eligible for DBS. The goal is to see if the treatment improves q…

This study tracks 125 adults with early advanced Parkinson's disease in Germany who are prescribed a drug called Foslevodopa/Foscarbidopa. The goal is to see how well it reduces 'OFF' time (when symptoms return between doses) and improves quality of life, thinking, and work abili…

This early-stage study tests a new treatment called DSP-1083, which is implanted directly into the brain using a precise surgical method. The goal is to see if it is safe and if it can improve symptoms for people with Parkinson's disease. About 25 adults aged 40 to 72 with Parkin…

This early-stage study tests an experimental drug called LY3962681 in healthy volunteers and people with Parkinson's disease. The main goal is to check safety and how the body processes the drug. Participants receive one or two injections into the spinal fluid and are followed fo…

This study tests deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well controlled by medication. A small device, like a pacemaker, is placed in the chest and sends electrical signals to specific brain a…

This study provides deep brain stimulation (DBS) therapy to 300 adults with Parkinson's disease, dystonia, or essential tremor. DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement, aiming to reduce symptoms like shaking and stiff…

This study tests whether a daily dose of D-serine, an amino acid, can slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks, followed by a 12-week break. Researchers will measure changes…

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already taking levodopa. The goal is to see if the drug can delay worsening of movement symptoms compared to a placebo. Participants receive the drug or placebo by…

This early-stage study tests whether injecting special nerve cells into the brain is safe for people with advanced Parkinson's disease. The cells are made from stem cells in a lab and are meant to replace damaged brain cells that control movement. The trial involves 12 adults age…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not well-controlled by current medications. The main goal is to check safety and find the best dose, while also looking for any signs of improv…

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a digital tool that helps doctors diagnose and tell apart these disorders more accurately. Researchers will c…

This study tests a new type of deep brain stimulation (DBS) that automatically adjusts to a person's needs in real time, called adaptive DBS. It aims to give people with Parkinson's disease more hours of good movement without side effects. The trial involves 62 participants in Ch…

This study tests whether adding personalized music therapy to standard physical therapy can improve walking and balance in people with Parkinson's disease. About 50 participants will receive either physical therapy alone or physical therapy plus rhythmic music cues for 8 weeks. T…

This study tests a non-invasive brain stimulation method called TIS in 36 people with Parkinson's disease. Participants get 10 sessions over two weeks, and researchers check if movement improves and if changes in brain activity can be seen. The goal is to see if this gentle stimu…

This study tests a tool called PARKINSUN that helps Parkinson's patients talk better with their doctors. About 120 adults with Parkinson's will either use the tool or not during checkups over 7 months. The goal is to see if it improves patient satisfaction and makes care more foc…

This study tests a small, non-invasive device that stimulates the vagus nerve through the neck to improve walking and balance in veterans with Parkinson's disease. About 40 veterans will use the device at home while researchers measure changes in stride length and freezing of gai…

This study tests if a gentle, non-invasive brain stimulation called temporal interference stimulation can help improve movement in people with Parkinson's disease. About 90 adults with Parkinson's will receive either real stimulation or a sham (fake) treatment for 30 minutes. Res…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people with Parkinson's disease. About 54 adults with mild to moderate Parkinso…

This very early study tests whether a spinal cord stimulation device (ARC-IM Therapy) can safely help manage sudden drops in blood pressure (orthostatic hypotension) in people with Parkinson's disease or related conditions. Only 5 participants will be enrolled to check safety and…

This study tests whether playing soft sounds during deep sleep can make cognitive training more effective for people with Parkinson's disease and mild memory problems. Fifty participants will do a 5-week brain fitness program at home while using a sleep device that either plays r…

This study tests a new way for people with Parkinson's disease to do rehabilitation exercises at home using a special stationary bike that can be monitored and adjusted remotely by a therapist. The goal is to improve movement and reduce symptoms without needing to travel to a cli…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, …

This study tests whether the sleep medication lemborexant can help both sleep problems and movement difficulties in people with Parkinson's disease. Researchers will enroll 44 adults aged 50 and older with Parkinson's and insomnia. The goal is to see if improving sleep also leads…

This study tests whether virtual reality exercises can improve balance and movement in people with Parkinson's disease better than traditional physical therapy. About 62 adults aged 45-65 with Parkinson's will be randomly assigned to either virtual reality or conventional therapy…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) stimulation in 50 adults a…

This study tests whether a smartphone app called Walking Tall can help people with Parkinson's disease improve their walking at home. Over 6 weeks, 30 participants will use the app, which provides rhythmic sounds and voice prompts to guide their steps. Researchers will measure da…

This study tests whether a single dose of IV ketamine can quickly improve depression in 80 veterans with Parkinson's disease who haven't responded well to standard antidepressants. Researchers will also measure changes in brain flexibility and inflammation to understand how ketam…

This study tests a breathing and meditation program called SKY Breath for people with early-stage Parkinson's disease (under age 75) and their care partners. Over 4 weeks, participants will learn and practice the technique daily to see if it lowers stress, anxiety, and fatigue wh…

This study tests whether a personalized form of transcranial magnetic stimulation (rTMS) can improve movement and non-movement symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty adults aged 30-80 will receive 10 daily se…

This study is testing whether a lightweight, wearable exoskeleton can help people with Parkinson's disease walk more safely and with fewer falls. Thirty veterans with mild to moderate Parkinson's will use the device during supervised walking sessions twice a week for eight weeks.…

This study follows 20 people with Parkinson's disease who have a brain procedure called focused ultrasound to stop tremors. Researchers want to find out why some people's tremors return within two years. Participants will have brain scans and tests before and after treatment to h…

This study is following 650 people with either early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers are using brain scans, heart tests, and fluid samples to track how the disease changes over time. The goal is to better …

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80, including those with and without depression. The goal is to identify targets for future treatments, not …

This study uses a new ultra-high-resolution PET scanner to see tiny brain structures in much more detail than before. Researchers will scan 300 healthy volunteers and people with Alzheimer's, Parkinson's, ALS, or psychotic disorders to find early signs of disease. The goal is to …

This study uses special PET scans to measure inflammation in the brains of people with diseases like Alzheimer's, Parkinson's, and ALS, compared to healthy volunteers. Researchers want to see if certain proteins called COX-1 and COX-2 are higher in diseased brains. About 184 adul…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study uses a powerful 7T MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's who have not yet started medication. Researchers will compare these measurements to those from healthy volunteers to better understand how the disease affects brain met…

This early-phase study tests a new imaging drug called [18F]MK-0947 that works with PET scans to show clumps of a protein called alpha-synuclein in the brain, which are linked to Parkinson's disease. About 22 adults with Parkinson's and healthy volunteers will receive the drug an…

This study observes 300 people with Parkinson's disease who still have movement problems despite taking standard medications. Researchers will collect data over up to 5 years to understand how the disease changes, how treatments work in real life, and the challenges patients and …

This study looks at why many Veterans with Parkinson's disease have trouble with balance and falls. Researchers will use wearable sensors to track movement and record brain signals from deep brain stimulation electrodes. The goal is to better understand the brain pathways involve…

This study follows 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will collect information from routine doctor visits over three years, including walking tests and question…

This study looks at how the exact placement of deep brain stimulation (DBS) affects movement in people with Parkinson's disease. Researchers will test 24 adults who already have DBS implants to see which stimulation spots improve or worsen motor symptoms. The goal is to learn how…

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will measure speech clarity, speed, and pauses in 50 participants. The goal is to find links that could lead to new therapies for bot…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers are checking for a protein called alpha-synuclein in colon tissue from 40 adults aged 40-99 who already have Parki…

This study looks at how deep brain stimulation (DBS) affects the ability to align and focus eyes in people with Parkinson's disease. Researchers will use eye-tracking and brain models to find the best stimulation settings for improving vision while still helping with movement pro…

This study aims to learn more about movement disorders like Parkinson's disease and tremors by observing and collecting data from affected individuals and their family members. Participants will undergo tests such as physical exams, blood work, and imaging scans during one or two…

This study aims to find a new marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 people over time to see how certain brain cells change as the disease progresses. The goal is to better understand Parkinson's, not to test a…

This study uses PET, SPECT, and MRI brain scans to better understand brain changes in Parkinson's disease. Researchers hope to find a biomarker that can help develop new medications to slow symptom progression. The study involves 42 adults aged 25-85 with Parkinson's disease.