Parkinson's disease

This phase 2 trial is testing whether an experimental drug called RO7568282 can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. Participants, aged 40 to 85, must be on stable levodopa monotherapy. The study compares the drug against a placebo …

This trial tests whether implanting dopamine-producing cells into the brain can improve motor function in people with Parkinson's disease. The cells, made from stem cells, are surgically placed into the putamen. The study focuses on safety and whether the treatment can reduce sym…

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study tests whether fecal microbiota transplantation (FMT) from healthy donors can improve motor and non-motor symptoms in people with Parkinson's disease. 58 participants will receive either FMT or a control, and their movement scores will be compared after 6 months. The go…

This phase 2 trial tests an injectable drug called GM1 in 276 people with Parkinson's disease who experience motor fluctuations (times when medication wears off). Participants are randomly assigned to receive GM1 or a placebo for about 12 weeks, while continuing their usual Parki…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This study tests whether using brain imaging and electrical signals to program deep brain stimulation (DBS) works better than the usual method for people with Parkinson's disease. Twenty adults aged 30 to 70 who are getting DBS will be randomly assigned to either standard program…

This study tests whether terazosin, a drug currently used for an enlarged prostate, can boost energy production in brain cells of people with early Parkinson's disease. One hundred participants will receive either terazosin or a placebo for 6 months. Researchers will measure chan…

This study looks at how people with Parkinson's disease experience OFF episodes, when medication wears off and symptoms return. Researchers will follow up to 120 adults who are prescribed Inbrija, an inhaled levodopa, as part of their usual care. Over three months, they will trac…

This trial tests whether laser acupuncture, a non-invasive treatment using light on specific back points, can ease constipation and improve sleep in people with Parkinson's disease. The study includes 60 participants with Parkinson's and constipation, who will receive either real…

This study tests whether combining a painless brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with balance exercises can improve walking and balance in people with Parkinson's disease. Twenty participants aged 40-80 will receive the combined…

This study tests whether the sleep medication lemborexant can improve both sleep and motor symptoms in people with Parkinson's disease. Forty-four participants will take either lemborexant or a placebo nightly for 28 days. Researchers will measure changes in sleep quality and mov…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can improve tremor and walking difficulties in people with Parkinson's disease. Fifty participants will be randomly assigned to receive either real or sham stimulation dai…

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests whether a custom foot wedge combined with balance exercises can improve walking and stability in people with Parkinson's disease. Thirty participants with moderate Parkinson's will either get standard physical therapy or the same therapy plus the wedge and specia…

This study tests whether applying menthol to the skin can improve motor symptoms and sleep quality in people with early-stage Parkinson's disease. Researchers will enroll 80 adults aged 30-80 who have had Parkinson's for less than 3 years and report poor sleep. Participants will …

This study tests a non-invasive device called Temporal Interference Stimulation (TIS) to see if it can improve movement in people with Parkinson's disease. The device uses electrical fields to stimulate deep brain areas without surgery. Twenty-four adults with mild to moderate Pa…

This pilot study tests whether a breathing exercise program (expiratory muscle strength training) can improve cough, swallowing, and drooling in people with Parkinson's disease who also have a forward-bent posture. About 28 adults with Parkinson's will participate. The goal is to…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

Levodopa, the main treatment for Parkinson's disease, must be absorbed from the gut to reach the brain. A natural enzyme in the stomach lining, called dopamine decarboxylase, can break down levodopa before it gets there. This trial studies 40 people with Parkinson's who are alrea…

This study investigates primary parkinsonian pain (PPP), a severe and hard-to-treat pain type in Parkinson's disease. Researchers want to see if PPP is linked to REM sleep behavior disorder (RBD), a condition where people act out their dreams. About 300 people with Parkinson's wi…

This study will measure how common and severe depression, anxiety, and sleep disorders are in 100 people with idiopathic Parkinson's disease. Researchers will use standard rating scales to assess these symptoms and see how they relate to the disease. The goal is to help doctors r…

This study explores whether dual-task training—doing two things at once, like walking while solving a puzzle—can improve self-efficacy (confidence) and physical function in people with Parkinson's disease. Researchers will compare different training types (motor-cognitive vs moto…

This study follows 6 people with Parkinson's disease who already received an experimental injection called RGL-193. Researchers will check their safety and brain enzyme activity over 5 years. No new treatment is given—this is just observation to see how the injection holds up lon…