PARKINSON'S DISEASE

This study tests an experimental drug called GM1 in 276 people with Parkinson's disease who have motor fluctuations—times when their medication wears off and movement becomes difficult. Participants receive either GM1 or a placebo injection over 85 days while continuing their usu…

This study tests whether terazosin, a common blood pressure medicine, can increase energy production in brain cells of people with early Parkinson's disease. About 100 participants will receive either terazosin or a placebo for 6 months. Researchers will measure energy levels in …

This study tests whether using brain scans and electrical signals from the brain to program deep brain stimulation (DBS) can improve movement and reduce 'OFF' time in people with Parkinson's disease. Twenty adults aged 30-70 who are getting DBS surgery will be randomly assigned t…

This study follows 6 people with Parkinson's disease who already received an experimental treatment called RGL-193, injected into the brain. Researchers will check for any safety issues over 5 years and measure how the treatment affects certain brain enzymes. The goal is to see i…

This study tests whether community-based screening and new treatments—including stem cell therapy and wearable brain-computer interface devices—can slow or stop memory loss in adults 55 and older with mild cognitive impairment (MCI). Researchers will enroll 600 participants acros…

This study looks at how well the drug Foslevodopa/Foscarbidopa works for people with early advanced Parkinson's disease. About 100 adults will receive the drug as a continuous infusion under the skin for up to 6 months. Researchers will track changes in daily 'off' time (when sym…

This study will test if adding a special foot wedge to balance training helps people with Parkinson's disease walk better and feel more stable. Thirty adults with moderate Parkinson's will either get standard physical therapy or the same therapy plus the wedge and extra training.…

This study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve movement and thinking in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of non-invasive magnetic pulses …

This early-stage study tests whether resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for 3 months. The main goal is to check for side effects and measure how the drug…

This study tests an experimental drug called Lu AF28996 in 150 adults with Parkinson's disease who still have ups and downs in movement control despite their current medications. The goal is to see if adding this drug can increase the hours each day when symptoms are well-control…

This early study tests whether a device that gently stimulates a nerve in the ear (taVNS) can be used safely at home to help with Parkinson's symptoms like walking and balance problems. Sixteen adults with Parkinson's will use the device for one hour each day over eight weeks. Re…

This pilot study tests whether a breathing exercise program (expiratory muscle strength training) can improve cough, swallowing, and drooling in people with Parkinson's disease who also have a forward-bent posture. About 28 adults with Parkinson's will participate. The goal is to…

This study tests a new, non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) for people with Parkinson's disease. The goal is to see if TIS can improve movement symptoms without surgery. The study will involve 24 adults with mild to moderate Par…

This study tests whether applying menthol to the skin can improve motor symptoms and sleep quality in people with early-stage Parkinson's disease. Researchers will measure changes using standard Parkinson's and sleep rating scales. The trial aims to enroll 80 adults aged 30-80 wh…

This study looks at 36 people with Parkinson's disease who already have a deep brain stimulation device. Researchers want to understand how forced versus voluntary cycling exercise changes movement, thinking, and brain activity. The goal is to learn why aerobic exercise helps Par…

This study looks at how deep brain stimulation (DBS) can help people with Parkinson's disease improve their eye coordination and focus. Researchers will use eye-tracking and brain models to find the best stimulation settings. The goal is to reduce double vision and improve daily …