PARKINSON'S DISEASE

This study tested whether exenatide, a drug already used for diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's took either exenatide or a placebo for 96 weeks. The goal was to see if the drug could protect nerve cells and red…

This early-phase study tested a low dose of lithium aspartate (30-45 mg daily) in 15 people with early-stage Parkinson's disease. The goal was to see if lithium could change brain MRI scans and blood markers linked to the disease. The study was small and focused on safety and bio…

This early-stage study tested a new drug called BIIB094 in 62 adults with Parkinson's disease. The main goal was to see if the drug is safe and tolerable when given as a shot into the spine. Researchers also looked at how the drug moves through the body. This study is now complet…

This early-stage study tested a gene therapy for Parkinson's disease. The treatment involved delivering a gene to a specific part of the brain to help control movement. The main goal was to check if the procedure is safe and tolerable for people with Parkinson's. Only 14 particip…

This study tested whether long-term aerobic exercise can slow the progression of Parkinson's disease. Researchers enrolled 57 adults aged 40 and older with mild to moderate Parkinson's. Participants exercised regularly to improve fitness, and the team measured changes in movement…

This early-stage study tested a gene therapy called BBM-P002 in 10 people with advanced Parkinson's disease. The main goal was to see if the treatment is safe and tolerable. Researchers also looked at whether it could improve symptoms and reduce the need for daily Parkinson's med…

This study tested a gene therapy that delivers a protective protein (GDNF) directly to the brain to help strengthen cells damaged by Parkinson's disease. 25 adults with advanced Parkinson's received the treatment through a special infusion during surgery. The main goal was to che…

This study tested a new deep brain stimulation (DBS) system that uses directional leads to more precisely target brain areas involved in Parkinson's disease. The goal was to see if this system could effectively improve motor symptoms while reducing side effects. Twenty-six adults…

This study tested a new treatment made from stem cells for people with Parkinson's disease. The goal was to see if it is safe and if it can slow down or reverse brain damage. Twelve patients who had Parkinson's for at least 5 years received a single injection of these cells into …

This study tested whether a brain region called the superior colliculus, which processes visual information, could serve as an early marker for Parkinson's disease. Researchers compared newly diagnosed Parkinson's patients (not yet on medication) with healthy volunteers using fMR…

This study looked at whether an 8-week mindfulness program (MBSR) can improve quality of life, thinking, and mood in people with Parkinson's disease. 107 veterans took part. The goal was to see if learning to focus on the present moment helps manage daily challenges.

This small study tested a digital therapy called DART that uses augmented reality to help people with Parkinson's disease and a deep brain stimulator improve their walking and balance. Seven adults completed the program, and researchers measured changes in motor function and walk…

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance problems in people with advanced Parkinson's disease. Six participants received the stimulation in a randomized, double-blind crossover design. The goal was to see if thi…

This small study tested whether spinal cord stimulation could improve walking in people with Parkinson's disease whose symptoms are not well controlled by medication. Five participants received a spinal cord stimulator, and researchers measured changes in walking ability and free…

This study tested whether repeated doses of ketamine, given through an IV, can safely reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to see how it might wor…

This study tested an experimental drug called CVN424 in 64 people with early Parkinson's disease who were not yet taking other Parkinson's medications. For 12 weeks, half received CVN424 and half received a placebo. The goal was to see if the drug could improve movement and daily…

This study tested a non-invasive brain stimulation technique called rTMS to see if it can safely reduce musculoskeletal pain in people with Parkinson's disease. Researchers used EEG to measure brain activity changes linked to pain relief. The goal was to find a new way to improve…

This study tested whether methylphenidate (Ritalin), a drug used for ADHD, can improve walking problems and attention in people with advanced Parkinson's disease. 69 participants with severe gait freezing took either the drug or a placebo for 3 months. Researchers measured steps,…

This study tested a combined speech and exercise program delivered remotely to 104 veterans with Parkinson's disease who had trouble speaking clearly. The goal was to see if the program could improve how well others understood their speech. The approach uses technology so patient…

This study tested whether stimulating the brain's surface (cortex) could help with mood and behavior problems in people with Parkinson's disease. Five participants received mild electrical pulses to areas involved in mood and decision-making. The goal was to see if this could red…

This early-stage study tested a new drug called UCB0022 in 100 healthy volunteers and people with Parkinson's disease. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked at how food affects the drug. This is a first step to see i…

This study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or compulsive eating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The goal was to see if the d…

This study tested three different non-invasive treatments to help people who have trouble swallowing after a stroke or due to Parkinson's disease. The treatments included gentle brain stimulation (tDCS) and electrical muscle stimulation. The goal was to see if these approaches co…

This small study tested whether combining aerobic exercise with virtual reality can improve walking, thinking, and balance in people with Parkinson's disease. Ten participants completed the program, and researchers measured changes in movement, cognition, and brain activity. The …

This small study tested the safety of using focused ultrasound to create a tiny lesion in the brain area that controls movement, aiming to ease Parkinson's motor symptoms. Seven adults with advanced Parkinson's took part. The main goal was to check for side effects and see if mov…

This study tested a non-invasive treatment called TENS (transcutaneous electrical nerve stimulation) for bladder issues in people with Parkinson's disease or a related condition called multisystem atrophy. The treatment involves placing a small electrical patch near the ankle for…

This study looked at how people with Parkinson's disease perceive the world around them, including vision and unusual experiences like seeing things that aren't there. Researchers tested 54 participants online using questionnaires and visual tasks. The goal was to better understa…

This study measured brain signals in 21 people with essential tremor or Parkinson's disease during deep brain stimulation (DBS) surgery. The goal was to understand how the brain's motor network produces tremor. The findings may help improve future treatments, but this study did n…

This study looked at how brain signals travel in people with Parkinson's disease. Researchers measured brain wave patterns in 23 participants to understand why certain abnormal rhythms appear. The goal was to learn more about the disease, not to test a new treatment.

This study looked at 700 people with Parkinson's disease to find clues that predict whether deep brain stimulation will improve their quality of life. Researchers tracked patients for up to 5 years after the procedure. The goal is to help doctors choose the right patients for thi…

This study explored how deep brain stimulation (DBS) changes the way people with Parkinson's disease explain positive and negative events, known as attributional style. Researchers assessed 32 participants using questionnaires to measure hostility and depression. The goal was to …

This study looked at 49 people with Parkinson's disease and healthy volunteers to understand how changes in two brain chemicals—dopamine and serotonin—relate to both movement and non-movement symptoms. Using special PET scans, researchers compared people at early, middle, and lat…

This study looked at the DNA of 2500 people, including those with and without Parkinson's disease, to find genetic mutations linked to the condition. Researchers focused on genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to improve genetic counseling and understand how Pa…

This study followed nearly 90,000 farmers and their spouses to confirm health changes they reported, such as asthma and Parkinson's disease. Researchers checked medical records and collected cheek swabs to verify diagnoses. The goal was to better understand how pesticides and oth…

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (the body's balance center) rather than just a lack of dopamine in the brain. Researchers tested the inner ear function of 60 people with Parkinson'…

This study looked at blood cells from people with Parkinson's disease, ALS, and healthy volunteers to understand how a drug called deferiprone affects cell stress and energy use. Researchers collected samples from 90 participants and tested the drug in the lab. The goal was to le…

This study looked at 70 people with Parkinson's disease to see if following the DASH diet (a heart-healthy eating plan) was linked to better heart health markers. Researchers measured things like blood fats, blood sugar, and inflammation. The goal was to understand the connection…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how dopamine problems affect these conditions. No treatment was given; it was pur…

This study aimed to find genetic causes of Parkinson's disease by observing over 20,000 participants diagnosed within the last 5 years. Researchers focused on identifying people with a specific gene change (LRRK2) and developing a biomarker for that group. The study did not test …

This study looked at whether a special video game (serious game) could be a practical and liked way to help 10 Parkinson's patients improve their walking and balance. All participants had already had brain surgery for their condition. The main goal was to see if patients would us…