PARKINSON'S DISEASE

This study is testing whether a specific type of partnered dance exercise is better than regular walking at reducing Parkinson's disease symptoms and potentially protecting the brain. Researchers will compare the two activities in 82 people with mild to moderate Parkinson's over …

This early-stage study is testing the safety of a new gene therapy for Parkinson's disease. Researchers are delivering a gene called GDNF directly into a specific brain region in 11 participants to see if it can protect the cells that produce dopamine. The main goal is to check f…

This early-stage study is testing a new gene therapy, VGN-R09b, for Parkinson's disease. It aims to see if the treatment is safe and if it can help control motor symptoms in people whose current medications aren't working well enough. The therapy is delivered via a one-time injec…

This early-stage study is testing the safety of a new approach for Parkinson's disease. During a standard deep brain stimulation (DBS) surgery, doctors also implant a small piece of the patient's own nerve tissue into specific brain areas. The goal is to see if this implanted tis…

This study is testing whether an investigational drug called BIA 28-6156 can slow the worsening of movement problems in people with Parkinson's disease who have a specific genetic change in the GBA1 gene. About 237 participants will take either the drug at one of two doses or a p…

This study is testing whether an intravenous drug called prasinezumab can slow the progression of Parkinson's disease in people who are in the early stages. Over 300 participants will receive either the drug or a placebo for one year, with the option to continue treatment for up …

This study is testing whether very low doses of radiation, guided by special brain scans, can slow the progression of Parkinson's disease. Researchers will give five radiation treatments to 20 participants with early-stage Parkinson's and measure changes in their movement symptom…

This early-stage study is testing the safety and feasibility of a new approach for Parkinson's disease. During a standard deep brain stimulation surgery, doctors will also implant a small piece of the patient's own leg nerve into a specific area of the brain. The goal is to see i…

This study is testing whether a special exercise program can help people with Parkinson's disease improve their balance, walking, and thinking skills. Participants will do computer-based brain training along with walking and balance exercises that mimic real-life challenges, like…

This study is testing whether daily exposure to bright light can help improve sleep quality and reduce daytime sleepiness in people with Parkinson's disease. Researchers are enrolling 65 participants who have Parkinson's and poor sleep to measure changes in their sleep patterns a…

This study is tracking the long-term safety and effectiveness of an experimental gene therapy called AB-1005 in people with Parkinson's disease or a related condition called MSA. It follows 132 participants who received the therapy in earlier trials to see how well they tolerate …

This study aims to improve the tests used to diagnose chronic autonomic failure, a condition where the body's automatic functions like blood pressure control stop working properly. Researchers will enroll about 89 adults with conditions like Parkinson's disease, multiple system a…

This study aims to better understand how early Parkinson's disease and a related condition called multiple system atrophy progress over time. Researchers will follow 150 participants for 18 months, tracking their symptoms, movement abilities, and quality of life. The goal is to g…

This study aims to translate a Parkinson's disease cognitive assessment scale into Turkish and check if it works reliably. Researchers will test the translated scale on 60 Turkish patients with Parkinson's disease to see if it accurately measures their thinking and memory problem…

This study follows Parkinson's disease patients with and without a specific gene mutation (GBA) to see how quickly their brain networks change over time. Researchers use brain scans (PET and MRI) to measure these changes, hypothesizing that patients with the GBA mutation experien…