PARKINSON'S DISEASE

This early-stage study tests a gene therapy called AAV2-GDNF in 11 people with Parkinson's disease. The treatment delivers a protein that helps protect brain cells. The main goal is to check safety, but researchers will also look at whether it improves movement symptoms.

This early-stage study tests whether implanting a small piece of a patient's own nerve tissue into the brain during deep brain stimulation (DBS) surgery is safe and feasible for people with Parkinson's disease. The nerve tissue contains cells that produce growth factors, which ma…

This study tests an experimental drug, BIA 28-6156, in 237 people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay worsening of motor symptoms over 78 weeks compared to a placebo. Participants are randomly assigned to …

This early-stage trial tests the safety of taking a small piece of nerve tissue from a person's leg and placing it into a key brain area during deep brain stimulation (DBS) surgery for Parkinson's disease. Ten participants will be followed for 12 months, then yearly for life. The…

This study tests whether ultra-low doses of radiation, guided by special brain scans, can slow the worsening of motor symptoms in Parkinson's disease. Twenty adults aged 45 to 70 with early-stage Parkinson's will receive five daily treatments. The goal is to see if this anti-infl…

This early-stage study tests a gene therapy called VGN-R09b in 39 people with Parkinson's disease whose motor symptoms are not well controlled by current medications. The main goal is to check safety and tolerability, while also measuring changes in movement and daily function. T…

This study tests an experimental drug called prasinezumab in 316 people with early Parkinson's disease. The drug is designed to target and remove clumps of a protein linked to Parkinson's. Participants receive either the drug or a placebo for 52 weeks, with an option to continue …

This study tests a non-invasive device that delivers gentle vibrations to the skin to help improve movement in people with moderate Parkinson's disease. The treatment aims to disrupt abnormal brain signals that cause stiffness and slowness. Thirty participants will use the device…

This study looks at whether partnered dance aerobic exercise can improve movement and thinking in people with Parkinson's disease. About 82 participants will take part, focusing on reducing 'OFF-time' when medications don't work well. The approach combines aerobic exercise with c…

This study tests whether doing physical and cognitive exercises at home, guided by telemedicine, can reduce chronic pain in people with Parkinson's disease. 166 Veterans with Parkinson's and chronic pain will participate. The goal is to find an easy, affordable way to manage pain…

This study looks at whether bright light exposure can improve sleep and daytime alertness in people with Parkinson's disease. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to find a simple, non-drug way to…

This study tests whether adding specific cognitive training to balance and gait exercises helps people with Parkinson's disease improve their walking, balance, and thinking. Fourteen participants with mild to moderate Parkinson's will undergo 12 training sessions. The goal is to …

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can improve depressive symptoms in people with Parkinson's disease. About 50 adults with mild to moderate depression and Parkinson's will receive either real or sham (fake) stimulation. Researcher…

This study tests whether a year-long mindfulness-based therapy can reduce stress, anxiety, and depression in 174 people with Parkinson's disease. Participants are randomly assigned to either the mindfulness program or their usual care. The goal is to see if lowering stress improv…

This study translates a scale that measures how thinking problems affect daily life in people with Parkinson's disease into Turkish. Researchers will check if the Turkish version is accurate and reliable by comparing it to other cognitive tests. About 60 adults with mild to moder…

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what is causing it. Researchers will study 320 participants to better understand the link between …

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. About 89 adults with Parkinson's disease, multiple system atrophy, or related conditions will undergo a series of t…

This study follows 132 people with Parkinson's disease or multiple system atrophy who previously received AB-1005 gene therapy in earlier trials. Researchers will track participants over time to see how safe the treatment remains and how long its benefits last. The goal is to bet…

This study follows 150 people with early Parkinson's disease or Multiple System Atrophy (a related condition) for up to 18 months. Researchers measure symptoms and biological markers to understand how these diseases progress. The goal is to gather information that will help desig…

This study follows 32 people with Parkinson's disease to see if those with a specific gene change (GBA mutation) have faster changes in brain activity over time. Participants will have brain scans and tests of movement and thinking. The goal is to understand how genes influence t…