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New hope for swallowing troubles: brain zaps and muscle therapy show promise

NCT ID NCT07152899

Symptom relief Sponsor: IRCCS National Neurological Institute "C. Mondino" Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two non-invasive treatments—brain stimulation (tDCS) and neuromuscular electrical stimulation (NMES)—to help people with swallowing difficulties caused by stroke or Parkinson's disease. A total of 110 adults aged 18 to 85 took part. The goal was to see if these therapies could improve swallowing safety and function, measured by standard scales. The results could lead to better rehabilitation options for these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial Direct Current Stimulation (tDCS) and Neuromuscular Electrical Stimulation (NMES)
What this could lead to
If successful, these treatments could offer a non-invasive way to improve swallowing and reduce choking risk in people with stroke or Parkinson's disease.
What could go wrong
This is a completed early-stage study with no phase designation, so results are preliminary. The treatments may not work for everyone, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Jun 2021

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-85 years * Diagnosis of post-stroke or Parkinson's disease-related dysphagia * Dysphagia duration ≥ 2 weeks for post-stroke patients and ≥ 6 months for Parkinson's disease patients * Ability to undergo rehabilitation therapy * Written informed consent obtained Exclusion Criteria: * Severe dysphagia requiring Percutaneous Endoscopic Gastrostomy (PEG) feeding for more than 1 year * Non-neurogenic causes of dysphagia * Contraindications to tDCS or NMES * Cognitive impairment affecting compliance with treatment

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Conditions

The condition(s) this trial relates to.

Deglutition Disorders Parkinson disease stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease Stroke, complication

Contacts and locations

Locations

  • Translational Neurophysiology

    Pavia, 27100, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.