Could zapping the brain lift mood in Parkinson's?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to give informed consent for the study * Age 30-75 * Diagnosis of Parkinson's disease by a movement disorders specialist * Movement disorder symptoms that are sufficiently severe, in the setting of best medical therapy, to warrant surgical implantation of deep brain stimulators according to standard clinical criteria * UPDRS-III score off medication between 20 and 80 and an improvement of at least 30% in the baseline UPDRS-III on medication score, compared to the baseline off-medication score. OR Patients with tremor-dominant PD (a tremor score of at least 2 on a UPDRS-III sub-score for tremor), treatment resistant, with significant functional disability despite maximal medical management OR Patients intolerant to medication causing significant functional disability * Have one or several mild to moderate mood or impulsive behavior as defined by: 1. depression (BDI\>=13) 2. anxiety (BAI \>=7) 3. impulsive behavior as indicated by a positive score on the Questionnaire for Impulsive-Compulsive disorders in Parkinson's Disease (QUIP-A) or as determined by clinical interview or informant report 4. Mood or behavior symptom fluctuations corresponding to minimum 30% improvement in non-motor symptoms when comparing visual analogue scales (VAS) scores in the on versus off medication state * Stable doses of anti-Parkinsonian medications for at least 30 days prior to their baseline assessment. Exclusion Criteria: * Pregnancy or breast feeding * MRI showing cortical atrophy out of proportion to age * MRI showing focal brain lesions that could indicate a disorder other than idiopathic PD * Major comorbidity increasing the risk of surgery (prior stroke, severe hypertension, severe diabetes, or need for chronic anticoagulation other than aspirin) * Any prior intracranial surgery except DBS surgery * Significant cognitive impairment (MoCA\<20). * History of seizures * Immunocompromised * Has an active infection * Requires diathermy, electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) to treat a chronic condition * Inability to comply with study follow-up visits * Any personality or mood symptoms that study personnel believe will interfere with study requirements.