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Zap away Parkinson's tremors? new brain stimulation shows promise

NCT ID NCT07309198

Symptom relief Sponsor: Shanghai University of Sport Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a gentle, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) can improve movement problems in people with Parkinson's disease. Thirty-seven participants received either real or sham stimulation over 10 sessions in two weeks. Researchers measured changes in motor symptoms and brain activity to see if TIS offers lasting benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial Temporal Interference Stimulation (TIS) device
What this could lead to
If it works, this could offer a non-invasive, drug-free way to ease movement symptoms in Parkinson's disease, potentially reducing reliance on medication.
What could go wrong
This is a small, early-stage study with only 37 participants. The effects may be modest or short-lived, and the sham comparison may not fully account for placebo effects. Results need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

37 people

The number who actually took part.

Started

Dec 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A physician-diagnosed idiopathic Parkinson's disease (PD) according to the Movement Disorder Society (MDS) diagnostic criteria, with onset after the age of 40. * Stable antiparkinsonian medication regimen, including levodopa-containing therapy, unchanged for at least 4 weeks before and during the trial. * Hoehn and Yahr (H\&Y) stages 1.5 to 3 and ability to walk unassisted. * Absence of dementia, defined as a Montreal Cognitive Assessment (MoCA) score ≥ 21. Exclusion Criteria: * Any contraindication for MRI or transcranial temporal interference stimulation (TIS), including claustrophobia, metallic implants in the head or heart, or a history of electroconvulsive therapy. * Current use of antipsychotic, antidepressant, or other dopamine-modulating medications. * Presence of orthopedic conditions that may interfere with motor assessments, such as osteoarthritis or recent orthopedic surgery (within the past 6 months). * History of physician-diagnosed major psychiatric illness. * Physician-diagnosed cardiovascular risks that could contraindicate exercise or study participation. * Prior history of deep brain stimulation (DBS) surgery.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease

Contacts and locations

Locations

  • Shanghai University of Sport

    Shanghai, Shanghai Municipality, 200438, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.