OVERWEIGHT AND OBESITY

This study tested whether wearing special glasses that detect eating, combined with smartphone messages, could help people change their eating behavior. Researchers worked with 43 adults who were overweight or had obesity to see if these real-time prompts could reduce how much th…

This study tested whether adding a new drug called apitegromab to a standard weight loss medication could help overweight and obese adults. The main goal was to see if the combination helped people lose more body fat while preserving their lean muscle mass. Researchers measured c…

This study tested if a low-calorie diet with three meals a day works better than the common five-meal plan for managing type 2 diabetes. It involved 50 adults with diabetes and overweight, comparing how the two meal schedules affected blood sugar control, weight, and other health…

This study tested a dietary supplement called GLP-1 Booster, which is designed to help the body naturally produce more of a hormone that controls blood sugar and reduces appetite. Overweight adults took either the supplement or a placebo for 26 weeks while researchers measured ch…

This study tested whether a medication called amiloride could improve the health and flexibility of blood vessels in overweight adults with insulin resistance. 137 men and women, aged 30-70, were randomly assigned to take either amiloride or a placebo pill for 24 weeks. Researche…

This study tested whether playing online brain-training games could help people develop healthier eating habits. Researchers worked with 630 overweight or obese adults to see if improving mental decision-making skills would lead to better food choices. The goal was to help partic…

This study compared two types of time-restricted eating schedules in overweight adults with metabolic syndrome. Researchers tested whether eating earlier in the day or later in the day was more effective for improving health. They measured changes in body weight, abdominal fat, b…

This study tested whether taking a specific probiotic (Bifidobacterium breve) could help healthy, overweight adults lose body fat. For 12 weeks, 95 participants took either the probiotic or a placebo pill while also following an exercise program. Researchers measured changes in b…

This study tested whether an online family support program could work well alongside a standard weight loss program for Black adults. Researchers wanted to see if adding family skills training online would be practical and acceptable to participants. The program focused on improv…

This study tested whether adding social gaming features to a weight loss app helped people lose more weight. Researchers compared two versions of an app over one year in 240 adults who were overweight or obese and had risk factors for type 2 diabetes. One app version used game-li…

This early-stage study tested a new injectable drug, TE-8105, for weight loss in overweight or obese adults without diabetes. The main goals were to check if the drug is safe, how the body handles it, and if it affects body weight. Researchers gave single and multiple doses to 38…

This study tested if a medication called eplerenone could improve heart health in overweight or obese people with high blood pressure or related conditions. It compared eplerenone to another standard blood pressure drug to see which was better at improving blood flow and reducing…

This early-stage study tested the safety and how the body processes a new injectable drug called HDM1005 in people who are overweight or obese. Forty participants received either the drug or a placebo (inactive shot) at different dose levels to see how well it was tolerated. The …

This small, completed study tested two practical ways to help adults with overweight or obesity who find it hard to afford healthy food. For 8 weeks, 48 participants either received vouchers to buy fresh produce or had boxes of their preferred fruits and vegetables delivered to t…

This early-stage study tested a small, implanted device that slowly releases a drug called exenatide. It involved 24 overweight adults to see if the implant was safe and how the drug behaved in their bodies. The goal is to develop a long-term treatment option for managing weight …

This study tested whether eating more dairy foods could help control inflammation and improve markers of heart health. Overweight adults who normally ate little dairy were asked to eat 3 servings of dairy daily for 6 weeks. Researchers measured their blood for signs of inflammati…

This study tested whether sending specific, well-timed messages through a phone app could help young adults with overweight or obesity stick to daily weight loss behaviors. Over 200 participants used an app with lessons, tracking, and daily goals for weighing, activity, and food.…

This was an early-stage study to test the safety of a new drug called HS235 in people who are overweight or obese. It involved 39 healthy adults to see how their bodies processed the drug and to check for any side effects. The main goal was to gather initial safety data to see if…

This study tested whether taking betaine, a natural substance, for 8 weeks could help overweight and obese women. Researchers wanted to see if it could reduce body fat, improve cholesterol levels, and affect genes related to fat metabolism. The study involved 54 women who were ra…

This study tested whether a phone-based health coaching program could help pregnant women manage their weight gain during pregnancy. Researchers enrolled 534 women from diverse backgrounds who were overweight or obese early in pregnancy. The program used phone calls, a website, a…

This study tested whether actively involving fathers during pregnancy and their baby's first year could help prevent rapid weight gain and obesity in infants. Researchers enrolled 657 mother-father pairs from minority backgrounds and randomly assigned them to receive either stand…

This program aimed to prevent obesity by helping mothers and their young children develop healthy habits. It worked with over 1,600 families at community health centers in Boston, focusing on diet, activity, sleep, and social needs like food and housing security. The goal was to …

This study tested a before-school exercise program called BOKS to see if it helped children. Researchers followed 188 kids aged 5-14 in three Massachusetts schools during 2018. They measured changes in the children's weight, quality of life, and thinking skills to see if the prog…

This study tested whether a new oral medication called NG101 could help manage the common stomach-related side effects (like nausea) that people often experience when starting GLP-1 weight-loss drugs like semaglutide. In this completed Phase 2 trial, 120 healthy adults with a BMI…

This study tested whether a structured weight loss and behavioral support program could reduce symptoms related to atrial fibrillation (AF) in older, overweight patients. 119 participants aged 60-85 with persistent AF were randomly assigned to either the weight loss program or us…

This study tested whether doing Pilates two days a week or three days a week leads to better results when the total number of sessions is the same. Researchers enrolled 51 women with overweight or obesity to compare the two schedules over several months. They measured changes in …

This study tested whether a new mindful eating program could help French adults with overweight or obesity. 56 participants were randomly assigned to either the 8-week mindful eating program or a standard dietary advice program. The researchers compared changes in eating habits, …

This study tested whether a supervised, year-long exercise program could improve physical health and psychological well-being in older women. Researchers compared 108 women aged 60+ who either did the twice-weekly exercise program or continued their usual daily activities. The go…

This small, completed study aimed to understand how a person's weight and metabolism might affect their brain's response to food and their food preferences. Researchers tested 20 adults with a range of body weights, using taste tests, brain scans (fMRI), and metabolic measurement…

This study aimed to understand if a stress hormone released when we eat (glucocorticoids) influences how our bodies store fat. Twenty-three overweight and obese men participated. They underwent periods of controlled overeating while receiving either a treatment to block this horm…

This early-stage study aimed to understand how a single dose of an experimental drug called AMG 133, being developed for overweight and obesity, is processed by the body in people with normal and impaired kidney function. It involved 44 adults to measure the drug's levels in the …

This early-stage study tested the safety and how the body processes a new tablet made from mulberry twig alkaloids. It involved 62 healthy and overweight volunteers in China. The main goal was to see if the tablets were safe and to measure how much of the drug gets into the blood…

This study aimed to find out if a single session of isometric exercise (like planks and squats) or aerobic exercise (like running) is better at improving blood pressure in teenagers with overweight or obesity. Researchers enrolled 38 teens aged 13-17 and randomly assigned them to…

This study looked at how a single session of moderate or high-intensity exercise changes what's in breast milk. Researchers compared milk from 32 breastfeeding women with overweight or obesity after exercise and after rest. They measured hundreds of natural compounds in the milk …

This study aimed to understand if low-grade inflammation in the body makes it harder for people with overweight or obesity to choose healthier foods that require more effort. Researchers gave 59 overweight women either an anti-inflammatory drug (colchicine) or a placebo and used …

This study aimed to understand how a low-calorie diet, combined with either a low-carb or moderate-carb approach, affects exercise ability and health in overweight women. Researchers compared two groups of 20 women each over 10 days, measuring their fitness, metabolism, and body …