OVERWEIGHT AND OBESITY

This study looked at whether eating only during certain hours of the day (early or late) helps overweight adults with metabolic syndrome lose weight and belly fat. About 100 adults followed either an early or late eating schedule. The goal was to see which timing works better for…

This study tested whether adding game-like social features to a weight loss app helps adults with overweight or obesity and type 2 diabetes risk lose more weight. 243 adults used a mobile app that rewarded self-monitoring and supportive interactions, with one group also getting s…

This early-stage study tested the safety and drug levels of an exenatide implant placed under the skin in 24 overweight or obese adults without diabetes. The implant slowly releases medication to help control blood sugar and weight. Researchers measured how much drug entered the …

This early-stage study tested a new drug called TE-8105 in 38 overweight or obese adults without diabetes. The main goal was to check if the drug is safe and to see how it affects body weight. Participants received injections of the drug, and researchers monitored side effects an…

This study tested whether amiloride, a drug that blocks a sodium channel (ENaC), can improve artery function and reduce stiffness in overweight adults with insulin resistance. 137 pre- and postmenopausal women and age-matched men participated. The main measure was carotid-femoral…

This study looked at the best way to give fresh produce to adults who are overweight or obese and have trouble getting enough healthy food. 48 participants were split into two groups: one got weekly vouchers to buy produce, and the other got free produce boxes delivered to their …

This study compared two blood pressure medicines—eplerenone and chlorthalidone—in 79 adults with obesity and high blood pressure or metabolic syndrome. The goal was to see if eplerenone could improve blood flow to the heart and reduce scarring, beyond just lowering blood pressure…

This study tested a 12-week program for overweight Hispanic mothers and their 3-5 year old children. The program included nutrition education, exercise, and coping skills training, plus monthly check-ins for 6 months. Researchers measured changes in weight, body fat, and health b…

This study looked at whether weighing yourself every day can help adults with obesity stop gaining weight. About 400 people received an electronic scale and were asked to weigh themselves daily. The goal was to see if this simple habit, supported by their primary care clinic, cou…

This study tested a new drug called CPX101 to help people who are overweight or obese lose weight. The trial included 240 adults without diabetes who received either the drug or a placebo over 24 weeks. The main goal was to see how much weight they lost and if the drug was safe.

This study tested whether taking betaine (a natural substance found in beets) for 8 weeks can help overweight and obese women lose body fat and improve their cholesterol levels. Fifty-four pre-menopausal women took either betaine or a placebo pill daily. Researchers measured body…

This study looked at whether eating only within a 10-hour window each day helps overweight or obese adults aged 50-75 with prediabetes lose weight and improve their heart health. Participants either followed the 10-hour eating plan or their usual longer eating schedule, while tra…

This study tested a drug called apitegromab in 102 overweight or obese adults who were also taking a GLP-1 weight-loss medication. The goal was to see if apitegromab could help preserve lean body mass (muscle) while losing weight. Participants received either apitegromab or a pla…

This study tested a new version of an adjustable stomach balloon (Spatz4) in 20 adults with a BMI of 27 or higher. The balloon is placed in the stomach and can be adjusted later to help with weight loss. The main goal was to see if the adjustment procedure works correctly in most…

This study tested a supplement called GLP-1 Booster in 69 overweight adults to see if it helps control blood sugar, reduce body fat, and manage weight. Participants took the supplement or a placebo for 26 weeks. The goal was to see if the supplement safely boosts the body's own G…

This study tested a mobile health program for overweight or obese pregnant women to help them gain a healthy amount of weight during pregnancy. Two hundred women used a smartphone app with diet and exercise guidance, plus a fitness tracker, for about six months. The goal was to s…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study looked at how eating different amounts of pecans each day for 28 days affects heart health in 108 adults who are overweight or have high cholesterol. Participants ate pecans as part of their diet or stuck to their usual eating habits. Researchers measured changes in bl…

This study tested whether eating 3 low-calorie meals per day helps control blood sugar and weight better than eating 5 small meals in people with type 2 diabetes who are overweight or obese. Fifty adults followed one of two diet plans for 11 weeks. Researchers measured blood suga…

This study looked at whether aerobic exercise can change body composition (fat, muscle, water, and bone) in overweight and obese boys aged 8 to 12. A total of 80 boys took part. Researchers measured body fat, lean mass, water, and bone mass before and after the exercise program. …

This study tested a new medication called Mazdutide to help adults with obesity or overweight lose weight. About 179 participants took the drug or a placebo for 32 weeks to see how much weight they lost. The goal was to find a safe and effective way to manage weight, but ongoing …

This study tested whether a probiotic called Bifidobacterium breve, taken alongside exercise, helps healthy but overweight adults lose more body fat. About 95 people with a BMI between 25 and 30 took either the probiotic or a placebo for 12 weeks. Researchers measured changes in …

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study looked at whether eating more dairy products for 6 weeks could lower inflammation and other markers of heart disease in overweight adults. Researchers measured these markers both when participants had fasted and after a high-fat meal. The study involved 32 adults who w…

This early-stage study tested a new injection called HDM1005 in 40 overweight or obese adults. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels …

This study tested a remote health coaching program for pregnant women with overweight or obesity. Over 500 women received phone coaching and used a web platform to track their health. The goal was to limit weight gain during pregnancy and prevent related problems like gestational…

This study tested whether helping fathers get involved during pregnancy and the first year of life can prevent rapid weight gain and obesity in babies. Over 650 families from diverse backgrounds took part. The program provided extra support to parents, focusing on healthy eating,…

This study tested a program to prevent obesity in mothers and children from pregnancy through age 2. It involved over 1,600 families at community health centers in Boston, focusing on healthy eating, physical activity, sleep, and addressing social needs. The goal was to reduce ob…

This early-stage study tested a new drug called HS235 in 39 overweight or obese but otherwise healthy adults aged 40 and older. The main goal was to check the drug's safety and how the body processes it. Researchers measured side effects and drug levels in the blood to understand…

This study looked at whether a 10-week tai chi or multimodal exercise program could improve balance in overweight and obese women. 75 women took part. The results showed that both types of exercise significantly improved balance and reduced fall risk, offering a safe way to help …

This study tested a special sensor worn on eyeglasses that tracks eating. The sensor sent messages to a smartphone to help people eat less and slow down. 43 adults with overweight or obesity wore the device for three weeks. The goal was to see if these messages could change eatin…

This study looked at whether doing Pilates two or three days per week makes a difference for women with overweight or obesity, as long as the total number of sessions is the same. 51 women were randomly assigned to either 12 weeks of Pilates three times a week or 18 weeks of Pila…

This study looked at whether a weight loss program could reduce symptoms of atrial fibrillation (an irregular heartbeat) in overweight adults aged 60 to 85. Participants either joined a diet and behavior support program or received usual care for about 8 months. The main goal was…

This early-phase study tested a new drug called CPX101 in 72 healthy volunteers and overweight or obese patients. The main goal was to check if the drug is safe and tolerable, and to see how the body processes it. Researchers also looked at whether multiple doses could help with …

This study looked at whether eating a diet high in fiber and low in sugar helps people with overweight or mild obesity control their blood sugar and feel fuller after meals. Twenty-four adults followed a special high-fiber diet for a short time, and researchers measured their blo…

This study tested an experimental oral medication, NG101, to see if it could reduce gastrointestinal side effects (like nausea and vomiting) caused by GLP-1 agonist injections, such as semaglutide. 120 healthy adults with a BMI between 22 and 35 took either NG101 or a placebo for…

This study looked at whether isometric exercises (like squats and planks) or aerobic exercises (like running) are better at lowering blood pressure in teenagers aged 13 to 17.5 who are overweight or have obesity. 38 teens took part in three visits, including blood tests, body mea…

This study looked at whether a 7-month low-carb, high-fat (ketogenic) diet could improve symptoms in women with lipedema, a painful fat disorder that mainly affects the legs. 121 women with lipedema and overweight or obesity followed the diet. Researchers measured changes in leg …

This study looked at whether a supervised exercise program done twice a week for 12 months could improve physical health and well-being in women aged 60 and older. The program focused on walking speed, leg strength, mobility, and waist size, and also measured motivation and feeli…

This study looked at how different amounts of cottonseed oil affect cholesterol, blood sugar, and other health markers in 95 adults at risk for heart disease. Participants drank shakes and ate snacks with cottonseed oil daily for 28 days. Researchers compared low, medium, and hig…

This study tested how eating peanuts affects inflammation and appetite in 17 older adults who were overweight. Participants ate two different meals—one with peanuts and one without—to compare their body's response. The goal was to see if peanuts, which are high in healthy fats, c…

This study tested whether sending specific text messages at the right time helps young adults with overweight or obesity meet their daily goals for weighing themselves, being active, and limiting certain foods. Over 200 participants used a mobile weight loss program and received …

This study looked at how the body processes nutrients and whether that affects food preferences in people with different body weights. Twenty adults with a BMI between 18.5 and 40 took part. Researchers measured how much participants liked and wanted certain flavors after learnin…

This study looked at whether colchicine, an anti-inflammatory drug, changes how the brain values effort and reward when choosing food. 59 overweight or obese women with mild inflammation took either colchicine or a placebo. Researchers used brain scans and behavior tests to see i…

This study looked at how a single dose of the experimental drug AMG 133 is processed in the body of people with normal kidney function compared to those with various levels of kidney problems. It involved 44 overweight adults. The goal was to gather safety and drug-level informat…

This study looked at whether stress hormones (glucocorticoids) released after eating cause overweight people to gain more body fat when they overeat. 23 overweight men were given either a drug that blocks these hormones or a placebo during two periods of overeating. The goal was …

This study looked at whether exercising in the afternoon is better than exercising in the morning for improving blood sugar control in people with pre-diabetes. Fifteen overweight or obese adults with pre-diabetes participated. The main goal was to measure nighttime blood sugar l…

This study tested whether adding amaranth protein to the diet could change the gut bacteria in children with overweight or obesity. Fifty-six children who had not taken antibiotics or other drugs recently took part. Researchers measured changes in gut bacteria and related health …

This study looked at how a 10-day diet that cuts calories and either limits or moderately reduces carbohydrates affects exercise ability and health in overweight women aged 20-35. Thirty-six women followed a reduced-calorie diet with either low or moderate carbs. Researchers meas…

This study tested a new mindful eating program designed for French adults who are overweight or have obesity. The program teaches people to pay closer attention to their eating habits and feelings. Researchers measured changes in mindful eating, anxiety, and depression in 56 part…

This study tested whether playing online games designed to improve decision-making skills can change people's attitudes about food. Over 600 overweight adults played the games, and researchers measured how fast and accurately they responded. The goal was to see if training the br…

This study looked at how a single session of moderate or high-intensity exercise changes the makeup of breast milk. 32 women who were exclusively breastfeeding and had overweight or obesity provided milk samples before, right after, and hours after exercise or rest. Researchers m…

This early-stage study tested a tablet made from mulberry twig alkaloids (WH006) in 62 healthy and overweight/obese adults in China. The main goal was to check the drug's safety and how it moves through the body, not to treat obesity. Results will help decide if further studies a…

This study tested a before-school exercise program called BOKS in three schools in Revere, MA. About 188 children aged 5 to 14 took part. Researchers measured changes in body mass index, thinking skills, and quality of life to see if the program helped.