Afternoon workouts may beat morning sessions for blood sugar control
NCT ID NCT06014684
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether exercising in the afternoon versus the morning makes a difference in blood sugar levels for people with pre-diabetes. Fifteen overweight adults aged 40-75 completed a 12-week high-intensity interval training program. The main goal was to see if afternoon exercise improves overnight glucose levels and insulin sensitivity more than morning exercise.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High Intensity Interval Training (HIIT) exercise program
- What this could lead to
- If successful, this could show that timing exercise in the afternoon is a simple way to better manage blood sugar in people with pre-diabetes.
- What could go wrong
- This is a very small, completed study with only 15 participants. Results may not apply to everyone, and the effect of exercise timing may be minimal or not reproducible.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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15 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 40-75 years. * Body mass index (BMI) ≥25 kg/m2 * Male, or postmenopausal (at least 1 year post cessation of menses) female * Pre-diabetes based on one or a combination of the following criteria: * Impaired Glucose Tolerance (IGT): plasma glucose values ≥ 7.8 mmol/l and ≤ 11.1 mmol/l 120 minutes after glucose drink consumption during OGTT in screening * ImpairedFastingGlucose(IFG):Fastingplasmaglucose≥6.1mmol/land≤6.9 mmol/l * Insulin Resistance: glucose clearance rate ≤ 360 mL/kg/min, as determined during the OGTT using OGIS120. * HbA1cof5.7-6.4% Exclusion Criteria: * Type 2 diabetes * Patients with active congestive heart failure and and/or severe renal and or liver insufficiency * Uncontrolled hypertension * Any contra-indication for MRI scanning * Alcohol consumption of \>3 servings per day for man and \>2 servings per day for woman * Smoking * Unstable body weight (weight gain or loss \> 5kg in the last 3 months) * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results. * Medication use known to hamper subject's safety during the study procedures. * Subjects who do not want to be informed about unexpected medical findings. * Men: Hb \<8.0 mmol/L, Women: Hb \<7.0 mmol/l * Heavily varying sleep-wake rhythm (i.e. night shift work and travels across time zones). * Significant food allergies/intolerance (seriously hampering study meals) * Blood donation during or within 2 months prior to the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Maastricht University
Maastricht, Limburg, 6229 ER, Netherlands
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