Keto diet shows promise for painful leg fat disorder in women
NCT ID NCT07530341
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a 7-month low-carb, high-fat (ketogenic) diet could improve symptoms and quality of life in 121 women with lipedema, a chronic fat tissue disorder causing painful leg swelling. Participants followed the diet and were monitored for changes in leg size, body weight, and inflammation markers. The goal was to see if this dietary approach could reduce pain and swelling better than standard treatments.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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121 people
The number who actually took part.
- Started
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Feb 2020
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * consent to participate in the study * diagnosis of lipedema proved by an angiologist * overweight or obesity based on BMI\>25 kg/m2 Exclusion Criteria: * pregnancy and period of 6 months after pregnancy, * breastfeeding, * diagnosis of lymphedema, * edema in the course of chronic vein insufficiency or heart failure, * diabetes mellitus, * kidney or liver failure, * hormonally unbalanced thyroid disease, * cancer * implanted cardiac devices (cardiac pacemaker, implantable cardioverter-defibrillator, resynchronization therapy) * metal implants
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Wroclaw Medical University
Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
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Other studies related to the condition(s) this trial covers.
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