OVERWEIGHT AND OBESITY

This study tests a program called PILI 'Āina to help Native Hawaiians better manage common health problems like type 2 diabetes, high blood pressure, and obesity. About 1,780 adults who are overweight and have at least one of these conditions will take part. The program focuses o…

This study tests a digital tool called HMZ 2.0 to help pregnant women with overweight or obesity gain a healthy amount of weight. 144 women will either use the tool or receive standard pregnancy advice. The goal is to see if the platform improves weight gain, sleep, eating habits…

This study is testing a new drug called AZD9550, alone or combined with another drug (AZD6234), to help people with obesity or overweight lose weight. The study includes people with or without type 2 diabetes. Researchers want to see if the drugs are safe, how the body processes …

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. Half will get the parenting progra…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (ages 18-35) with mild-to-moderate intellectual disabilities lose more weight and maintain that loss over 24 months. Participants will be split into two groups: one gets …

This study tests whether a postbiotic supplement (an inactivated microorganism in a gummy) can help overweight or obese adults lose body fat and improve metabolism. About 114 participants will receive either the supplement or a placebo for 12 weeks, along with nutritional advice.…

This study aims to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity by promoting traditional diets and cooking skills. About 210 adults from Hawaiian homesteads will take part in a program that includes dietary guidance, cooking demonstrations, and g…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. About 1,785 drivers will receive a combination of counseling, text messages, phone support, and self-monitoring tools. The goal is to find the most effective and affordable way to help this hard-…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks, with remote check-in…

This study tests whether using a mobile health app every day for 6 months helps people with overweight or obesity lose weight and improve their health. About 30 adults aged 18–64 with a BMI of 25 or higher will use the app, weigh themselves daily, and check their blood sugar. The…

This study tests whether drinking water before meals helps adults aged 50 and older with overweight or obesity lose weight. Participants will follow a reduced-calorie diet and be assigned to drink water before meals, spread water throughout the day, or have no water instructions.…

This study looks at whether combining time-restricted eating (eating only during a set window each day) with high-intensity interval training (short bursts of hard exercise) can help adults with overweight or obesity lose fat and improve their health. Over 12 months, 100 particip…

This study looks at whether drinking cottonseed oil just three times a week can lower cholesterol and other heart disease risks. Researchers will compare two different amounts of the oil against a no-oil group in 75 adults who are overweight or have high cholesterol. Participants…

This study tests whether a diet plan based on your genetic makeup helps you lose more weight and body fat than standard dietary advice. About 88 overweight adults will receive either personalized genetic counseling or general diet tips. Researchers will measure changes in body we…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and baby, especially in preventing childhood obesity. Researchers will follow 300 overweight or obese pregnant women and their infants for…

This study looks at whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity. Researchers will track the growth and health of 534 infants who receive the transplant shortly after birth. The goal…

This early study looks at whether a specific protein fragment (IRW) from egg whites can help manage high blood sugar and blood pressure. About 28 adults at risk for or with type 2 diabetes, plus healthy volunteers, will drink a smoothie with the protein and have their blood and b…

This study is testing a mobile app called Diet4painrelief that gives personalized nutrition advice to people with chronic pain who are also overweight. About 200 adults will either get standard pain rehab or rehab plus the app. Researchers will check if the app helps improve pain…

This study tests whether special behavioral programs can change how your brain reacts to food, helping you eat less and lose weight. About 228 adults with a BMI of 27 or higher will undergo 12 weeks of training and brain scans. The goal is to see if these programs reduce cravings…

This study aims to improve digital weight loss programs for adults living in rural areas, who often have less access to in-person help. About 616 participants will try a 24-week online program with different levels of support, like group video chats, personal coaching, or feedbac…

This study looks at whether adding special balance exercises to regular aerobic and strength training can improve balance, walking, and overall fitness in people who are overweight or obese. Forty adults with a BMI between 25 and 35 will be split into two groups: one doing standa…

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This early-stage study tests the safety and tolerability of an experimental drug called LAE103 in healthy overweight or obese adults, and also in healthy postmenopausal women. Researchers will give single or multiple doses to see how the body processes the drug and if it causes s…

This study is for 200 adults with overweight or obesity. Researchers want to see if two blood markers of inflammation (SII and SIRI) can help predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants wi…

This study looks at whether taking a special ketogenic drink every evening for 4 weeks can change how the body burns energy overnight and improve muscle health. Researchers will study 14 healthy but overweight adults aged 60-80 who are not very active. The goal is to understand t…

This study looks at whether a person's genetic makeup (specifically the CAV-1 gene) affects how well they respond to GLP-1 receptor agonist drugs (like Ozempic or Wegovy) for weight loss and heart health. Researchers will enroll 30 overweight or obese adults to measure changes in…

This study looks at whether exercising in the morning or evening helps overweight adults lose more weight and change their eating and sleeping habits. Researchers will track 128 people over 13 months to see how workout timing affects body weight, fat, and daily behaviors. The goa…

This study compares the effects of eating fresh watermelon versus low-fat cookies on sexual health, skin hydration, and gut health in overweight adults. Researchers will measure changes through questionnaires and skin tests. The goal is to see if watermelon offers unique wellness…

This study looks at how insulin resistance in type 2 diabetes harms blood flow to the heart and muscles, leading to poor exercise ability. Researchers will test if 15 weeks of exercise training can improve insulin sensitivity and restore blood flow. The study involves 150 sedenta…

This study looks at whether a natural smell can be detected in the fluid around the brain after people inhale it. Researchers will compare lean and obese participants to see if body weight affects this process. The goal is to understand how smells enter the brain, not to treat an…

This study looks at how being overweight or obese changes blood pressure responses during different breathing exercises and aerobic tests. Researchers will measure blood pressure in 80 healthy adults at rest and during exercise. The goal is to better understand the link between o…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study looks at how your fitness level relates to the bacteria in your mouth and how well blood flows to your muscles. Researchers will collect mouth swabs, saliva, and have participants do a cycling test. The goal is to understand these connections in people with heart failu…

This study looks at how fat tissue grows and changes when people gain weight over a short period. Researchers want to understand why some people develop health problems like metabolic syndrome or diabetes when they gain weight, while others do not. About 58 overweight adults will…