OVERWEIGHT AND OBESITY

This study tests a new program called ROC+ for people who are very responsive to food cues (like seeing or smelling food). It compares ROC+ to standard behavioral weight loss programs. 300 adults with overweight or obesity and high food responsiveness will participate. The goal i…

This study looks at whether eating oats every day for 6 weeks can lower cholesterol, reduce inflammation, and improve energy in adults who are overweight or have high blood pressure. Researchers will compare the effects of oats to rice. The goal is to understand how oats affect t…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study tests whether a time-saving, joint-friendly training method called whole-body electromyostimulation (WB-EMS) can lower resting blood pressure and improve other heart-related risk factors in people with mild hypertension who are overweight. About 28 participants will un…

This study tests whether a weight loss program delivered through a patient portal can help overweight adults lose weight and lower their cancer risk. About 229 participants will be randomly assigned to either an active program with coaching and tools or a comparison group with ba…

This study compares a 6-month online dietary and lifestyle program to standard hospital-based care for weight loss in Arab adults with overweight or obesity. Participants will be randomly assigned to either group, and researchers will track changes in body weight, diet, and quali…

This study compares a low-carb, high-protein diet to a standard diabetes diet in 100 adults with type 2 diabetes and overweight. Over 12 months, researchers will measure changes in blood sugar, weight, and heart health. The goal is to see if cutting carbs can better control diabe…

This study looks at whether a time-restricted eating plan (fasting 16 hours each day) can improve memory and thinking in overweight adults over 65 who have mild memory concerns. Participants either follow the fasting plan or attend healthy aging classes for 24 weeks. The goal is …

This study tests whether a natural supplement called motus can help overweight adults lose weight and body fat without requiring them to diet or exercise. One hundred participants will take motus daily, track their food and activity, and weigh in weekly for six months. The goal i…

This study looks at whether eating more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose more weight than a lower-protein diet. Over 10 weeks, kids follow a calorie-restricted diet and exercise program, then are followed for a year. The goa…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to eat early in the day, late in the day, or simply reduce daily calories for one yea…

This study tests a personalized 2-year educational program for overweight or at-risk children aged 6-8. The goal is to help them lower their body mass index (BMI) and avoid becoming obese adults. Researchers will compare results to a historical group of similar children who did n…

This study tests whether helping women with overweight or obesity adopt a healthy lifestyle before and during pregnancy can reduce the risk of their babies having excess body fat. About 360 women planning pregnancy will either receive a tailored program including a low-calorie di…

This study looks at whether a smart Fitbit app can help middle-aged adults (30–70 years old, overweight) walk more each day. The goal is to see if increasing light physical activity can protect brain health and lower the risk of Alzheimer's and related dementias. Participants use…

This study looks at whether helping overweight or obese women lose about 10% of their body weight before getting pregnant can lower the chance of their baby being born with too much body fat or becoming overweight in early childhood. About 240 women (and their partners, if they c…

This study tests whether giving betaine supplements to breastfeeding mothers can help prevent rapid weight gain in their babies, which is linked to later obesity. 47 mothers with overweight or obesity will take betaine or a placebo for 3 months while exclusively breastfeeding. Re…

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was acceptable and could improve quality of life, physical activity, and mood. Participants were cancer-free a…

This study looks at whether a weight loss program designed for adults who have had knee replacement surgery can help them lose weight, be more active, and have less pain and better function. About 182 overweight or obese participants will be followed for up to 18 months. The prog…

This study aimed to help children ages 8-12 with both ADHD and overweight or obesity. Parents would have learned special skills to support their child's behavior and executive function through online sessions. However, the study was withdrawn before any participants were enrolled…

This study follows 70 healthy infants in rural Pakistan from birth to age two. Researchers will regularly analyze their gut bacteria to see how diet and health affect microbiome development. The goal is to understand why some children become malnourished or overweight, even after…

This observational study reviews existing medical records of 300 adults with overweight or obesity who took weight management medications. Researchers want to see how much weight patients lost after 12 months and whether blood sugar and cholesterol levels improved. No new treatme…

This study looks at how eating foods made with soybean oil or palm oil for 4 weeks changes blood fats and body weight in overweight adults. Sixteen participants will eat three study foods each day and have their blood tested. The goal is to see if these oils affect health differe…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This early-stage study tests how the body absorbs an experimental weight-loss drug, maridebart cafraglutide, when given as two different types of injections. About 349 adults with overweight or obesity will receive a single dose to compare drug levels and check for side effects. …

This study tests a program called CONNECT that helps women and Black/Latino adults learn about and join heart health research. About 1,000 adults with heart disease or risk factors like high blood pressure or diabetes will receive text messages with health info and study opportun…

This study aims to reduce health gaps in Black and Latino communities by connecting people with health and social services. Researchers will track how many participants use these services and how satisfied they are. The goal is to build trust and improve health for those with dia…

This study looks at how exercising in the morning versus the evening, and on an empty stomach versus after eating, changes the way your body burns energy. Researchers will measure energy use and fat burning in 20 healthy adults with overweight or obesity during treadmill workouts…

This large study will follow 100,000 Chinese families from before pregnancy until children reach age 14. Researchers want to learn how parents' health, lifestyle, and environmental exposures before and during pregnancy affect pregnancy outcomes, child development, and long-term h…

This study looks at how aerobic or yoga training affects the way muscles process fat and sugar, which may influence insulin resistance—a condition that can lead to type 2 diabetes. Researchers will study 64 healthy, lean, or overweight adults before and after a 16-week supervised…

This study looks at how losing a small amount of weight (5% of body weight) changes insulin and testosterone levels in overweight women with insulin resistance. Researchers will measure these hormones before and after a weight loss diet. The goal is to understand the link between…