METABOLIC SYNDROME

This study looks at whether drinking a cranberry beverage can help overweight or obese adults improve their blood sugar, insulin levels, and cholesterol. Over 12 weeks, 73 participants will drink either cranberry or a placebo, then switch after a break. Researchers will also chec…

This study looks at whether limiting when you eat (time-restricted eating) can improve health in people with metabolic syndrome—a group of conditions like high blood pressure, belly fat, and high blood sugar. Researchers will test if adding a program that also addresses eating ha…

This study compares three weight loss methods—medication, surgery, and diet—to see which helps people with metabolic syndrome (obesity, type 2 diabetes, and high blood pressure) live longer and healthier. About 220 adults aged 35-55 will be followed for 24 weeks. The goal is to f…

This study tests a community program that uses an AI app and health coaches to help people with metabolic syndrome improve their eating habits and lower their risk of heart disease. About 316 adults aged 21 to 65 with a large waist and other risk factors will take part. The progr…

This study tests whether a 24-week program of eating only within an 8-hour window, walking over 10,000 steps daily, and cutting 500 calories can help obese adults with metabolic syndrome lose weight and improve heart health. After that, participants get either a GLP-1 or SGLT-2 m…

This study looks at whether time-restricted eating (eating only during a set number of hours each day) can improve health in people with metabolic syndrome or pre-diabetes. About 140 adults will either follow their usual diet or limit eating to a specific time window. Researchers…

This study tests whether eating only during a specific window each day (time-restricted feeding) can improve health in postmenopausal women with metabolic syndrome. Researchers will measure changes in insulin sensitivity, weight, and blood fats. The goal is to see if this simple …

This study looks at whether a special starch (resistant starch) can improve heart health and gut bacteria in women with Polycystic Ovary Syndrome (PCOS). About 100 women with PCOS will take either the starch or a placebo for 12 weeks. The goal is to see if this simple dietary cha…

This study tests whether daily foods with antioxidants, prebiotic fibers, and oat beta-glucans can improve blood sugar, weight, and cholesterol in 40 adults at risk of metabolic syndrome. Participants eat the special foods and attend clinic visits for blood tests and body measure…

This study tests whether a program combining a reduced-calorie Mediterranean diet, exercise, and lifestyle coaching can help middle-aged adults (30-50 years old) with metabolic syndrome lose 5-10% of their body weight and keep it off for a year. Researchers will compare this appr…

This study tests whether watching virtual reality (VR) scenes that mimic exercise can produce real health benefits in people who are sedentary and have prediabetes. Researchers will measure changes in blood sugar, walking endurance, and other markers after repeated VR sessions. T…

This study looks at how tiny air pollution particles and noise affect heart and metabolic health in 45-64-year-olds in Kaunas, Lithuania. It also tests whether daily walks in green spaces or a Mediterranean diet can improve health markers. About 180 participants will be randomly …

This study looks at whether exercise, a medication called liraglutide, or both together can improve blood flow to the heart and muscles and help the body use insulin better in adults with metabolic syndrome. About 80 people aged 21 to 60 will be randomly assigned to one of four g…

This study looks at whether treating Helicobacter pylori (a stomach infection) can also improve metabolic syndrome (high blood sugar, cholesterol, and weight). Researchers will give standard antibiotics to 120 adults with both conditions, and some will also get probiotics or berb…

This study looks at whether doing resistance exercises at different speeds can improve kidney function and metabolic health in people who have received a kidney transplant. Twelve adults aged 18 to 50 who had a transplant at least a year ago will be randomly assigned to train at …

This study tests whether combining mild electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension—high blood pressure that doesn't respond to multiple medications. Fifty men and women aged 50 to 60 will be split i…

This study looks at whether continuing GLP-1 agonist drugs (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to either keep taking the …

This study tests whether empagliflozin, a drug used for diabetes, can help people with HIV who are overweight or obese lose weight and improve their metabolism. About 66 adults with HIV on a specific type of antiretroviral therapy will take either the drug or a placebo for 6 mont…

This study looks at whether a daily capsule made from fermented fruits and vegetables (Rutazyme® lemon fermented product) can help improve metabolic health in adults with obesity. Forty adults aged 18 to 65 with a BMI of 27 or higher will take either the active capsule or a place…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults to see if the drug helps control disease risk. The goal is…

This study tests a new, non-surgical stomach procedure called Endoscopic Radial Compression Gastroplasty (ERCG) combined with lifestyle changes for weight loss in Chinese adults who are overweight or have mild-to-moderate obesity. The procedure uses a clip-and-loop system to redu…

This study tests whether breathing a special mix of low and high oxygen air (called IHHT) for 3 or 10 days can help control blood sugar in people with type 2 diabetes, including older adults. About 250 participants aged 50-74 will be randomly assigned to short or long treatment o…

This study tests whether combining intermittent fasting, calorie restriction, and increased physical activity can improve key health markers in adults with metabolic syndrome. Researchers in Riyadh will enroll 140 participants to measure changes in blood sugar, cholesterol, blood…

This study explores whether analyzing the chemicals in your breath can help doctors identify metabolic syndrome and metabolically healthy obesity without blood draws or invasive tests. Researchers will collect breath samples from 300 adults and use machine learning to find unique…

This study tests a personalized lifestyle program to help people with metabolic syndrome reverse the condition and lower their risk of heart disease. About 152 Chinese adults in Hong Kong will either receive the tailored program or standard brief advice. The program focuses on di…

This study tests whether taking part in racial justice activism can help prevent depression and reduce physical stress in Black and Latinx teens and young adults (ages 15-20). Researchers will measure depressive symptoms and stress-related health markers like blood pressure and w…

This study compares two ways to prevent heart problems in people with type 2 diabetes, prediabetes, or metabolic syndrome who are at higher risk but have no known heart disease. One group gets care based on a detailed heart scan staging system, while the other gets standard care …

This study looks at whether using a sit-stand desk can help prevent type 2 diabetes in people who are overweight and sit a lot at work. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to a con…

This study looks at whether nattokinase, a natural enzyme from fermented soy, can help people with early signs of metabolic syndrome and poor sleep. About 80 adults will take either nattokinase or a placebo for 12 weeks, then switch after a break. Researchers will check sleep qua…

This study tests whether a nutritional supplement containing inositol can improve symptoms like hair growth, acne, and irregular periods in women with Polycystic Ovary Syndrome (PCOS). Researchers will also check if it helps with metabolism, inflammation, and quality of life. The…

This study tests a non-invasive treatment called low-energy shock wave therapy for women with overactive bladder and metabolic syndrome. About 60 women will receive either the real treatment or a sham procedure. The goal is to see if this therapy can reduce symptoms like sudden u…

This study looks at whether adding aerobic exercise to standard counseling helps heavy drinking men who also have impotence and metabolic syndrome. Forty men will be split into two groups: one gets counseling only, the other gets counseling plus exercise. The goal is to see if th…

This study is for 200 adults with overweight or obesity. Researchers want to see if two blood markers of inflammation (SII and SIRI) can help predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants wi…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood of healthy adults aged 35 to 65. These particles help cells talk to each other and may affect heart and brain health. Researchers will compare blood samples …

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of 'good' fat that burns energy. Researchers will compare BAT activity in 100 healthy adults and people with metabolic syndrome, both at rest a…

This study looks at 8,000 obese young adults in eastern China to find out how genes and body traits are linked to obesity and metabolic syndrome. Participants must have a BMI of 30 or higher and be willing to give a blood sample. The goal is to learn more about what causes obesit…

This study is testing whether drinking whole-fat milk can improve cholesterol, blood sugar, and blood vessel function in adults with metabolic syndrome. Researchers will measure changes in blood fats, glucose, and artery health over time. The goal is to understand if whole-fat da…

This study follows over 4,000 adults from Shanghai communities to track how heart, kidney, and metabolic diseases develop and change over time. Participants were first checked between 2016-2017 and will be re-assessed through 2035. The goal is to understand risk factors and impro…

This study looks at whether women with PCOS have early signs of heart and blood vessel problems, and how different treatments might affect those signs. About 120 women will have their heart function tested before and after a sugar drink, and again after 6 months of treatment. The…

This study is observing 650 adults to understand how obesity and aging interact. Researchers will measure blood markers and body fat to see if obesity makes people age faster biologically. The goal is to lay groundwork for future treatments or lifestyle changes that could slow ag…

This study looks at whether metabolic syndrome harms the arteries in the neck differently in young men versus women, and if a 30-minute exercise session can temporarily improve that damage. Researchers will measure artery function before and after exercise in 48 young adults with…

This study looks at how changing physical activity levels impacts the body in adults aged 50-65 who are overweight. Some participants will reduce their activity for 3 months, then retrain, while others will increase activity to recommended levels. Researchers will measure fitness…

This study will follow 2,000 adults with metabolic syndrome or prediabetes for many years. Researchers will track health changes, risk factors, and complications to better understand how these conditions progress. The goal is to find key factors that affect long-term health outco…

This study is looking at whether an infection with H. pylori, a common stomach bug, is linked to more severe insulin resistance in people with metabolic syndrome. Researchers will compare 50 infected and 50 non-infected adults by measuring blood sugar, inflammation, and stomach h…

This study looks at how different types of protein (from animals or plants, and as whole foods or isolates) affect blood sugar control and insulin sensitivity in adults with metabolic syndrome. Researchers will measure blood sugar levels over 24 hours and how well the body respon…

This study looks at whether a protein called BNP, measured in babies and again in adolescence, can help identify teens at risk for metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and diabetes. Researchers will follow 70 teens who were born either ful…

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study follows 1,500 twins aged 15 to 44 over five years to learn how metabolic syndrome and related liver problems develop. Researchers will track new cases of fatty liver disease, fibrosis, and cirrhosis, and look at how genes, environment, and gut bacteria affect these con…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that could explain why some groups face higher risks for metabolic problems. No…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study looks at people with a rare condition called cerebral folate deficiency, where the brain doesn't get enough folate. Researchers think the problem may be in the choroid plexus, a part of the brain that helps control what goes in and out of brain fluid. They will use bra…

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study looks at how fat tissue grows and changes when people gain weight over a short period. Researchers want to understand why some people develop health problems like metabolic syndrome or diabetes when they gain weight, while others do not. About 58 overweight adults will…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…