METABOLIC SYNDROME

This study compares two weight-loss surgeries—standard duodenal switch and a newer version called SADI—in 56 adults with severe obesity (BMI over 45). Researchers track weight loss, health problems like diabetes and high blood pressure, and risks like malnutrition. The goal is to…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 participants, at least 3 months post-transplant, will follow a plant-based diet for 16 weeks. Researchers will track c…

This study tests a health behavior program designed to help adults with both metabolic syndrome and chronic kidney disease reduce their waist size and improve kidney function. 160 participants will be split into two groups: one receives the program, the other standard care. Resea…

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. The goal is to see if carnitine can improve arte…

This study looks at whether taking blueberry powder can help improve gut bacteria and reduce signs of metabolic syndrome (like high blood sugar and cholesterol) in overweight or obese adults. About 59 participants will take either blueberry powder or a placebo for a period of tim…

This study tests whether a 6-week exercise program, done twice a week, can improve physical and mental health in 100 adults with severe mental illness. Participants are randomly assigned to either usual care or usual care plus exercise. The goal is to reduce metabolic syndrome ri…

This study tests whether a weight loss program called "Paso a Paso" is practical for 50 Mexican and Central American adults with fatty liver disease and overweight. Researchers will check if participants attend enough sessions and if the program helps with weight loss, liver heal…

This study tests whether a time-saving, joint-friendly training method called whole-body electromyostimulation (WB-EMS) can lower resting blood pressure and improve other heart-related risk factors in people with mild hypertension who are overweight. About 28 participants will un…

This study looks at whether a daily supplement containing inositols and alpha-lactalbumin can help people with metabolic syndrome, a condition that raises the risk of heart disease and diabetes. About 30 adults who meet certain criteria (like high triglycerides, low HDL, or high …

This study tests a program called FIT Families, designed to help African American teenagers with obesity and their caregivers make healthier lifestyle changes together. The program is led by community health workers and is tailored to the families' needs. About 360 teens and thei…

This study looks at whether eating almonds every day for 12 weeks can help people with metabolic syndrome by improving gut health and lowering inflammation. About 80 adults aged 35-60 with signs of metabolic syndrome will participate. Researchers will measure changes in gut barri…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, diabetes, or high blood pressure. Participants use a tablet and fitness tracker at home, and some get extra support from a coach by video or …

This study tests if portable devices like handheld ultrasound and blood glucose monitors can find chronic diseases such as diabetes, heart disease, and kidney disease earlier than standard care. About 200 adults aged 18 to 75 will use these devices or receive usual care for 6 mon…

This study is testing a digital health platform called STELA that helps adults without heart disease lower their risk factors like obesity, high cholesterol, and insulin resistance. About 100 participants will get a full health check, a personalized prevention plan, and support t…

This study looks at how to prevent obesity in Latino infants by supporting mothers with coaching on feeding and sleep habits. About 256 mothers and their newborns will take part, receiving either group sessions or text-based guidance. The goal is to help babies grow at a healthy …

This study looks at whether taking a daily extract of yerba mate (a traditional South American drink) can improve health markers like weight, blood sugar, and cholesterol in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researc…

This study looks at whether teens and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced scans and tests to measure liver fat, insulin resistance, and cholesterol in 80 participants aged 14-25. Th…

This study looks at how eating pulses like beans and lentils changes the bacteria in your gut and affects how full you feel after a meal. Researchers will collect blood and stool samples from 44 overweight adults to measure appetite hormones and gut health. The goal is to underst…

This study looks at how pretzels made with safflower oil and soy affect energy use in overweight postmenopausal women with metabolic syndrome. Twenty women will eat different pretzels for one month each to see how their bodies process them. The goal is to learn if these snacks ca…

This study follows 500 adults with obesity who are trying to lose weight. Researchers collect data on their health, habits, and blood tests to find out what helps or hinders weight loss. The goal is to create personalized weight loss plans based on each person's unique profile.

This study looks at what happens when people who regularly drink sugary sodas switch to drinks sweetened with stevia or aspartame. Researchers want to see if these sugar substitutes change metabolism and gut bacteria for better or worse. About 41 healthy adults who drink 4 cans o…

This study looks at whether a simple, home-based walking program can help improve blood sugar, cholesterol, and body measurements in people living with HIV who also have metabolic syndrome. About 50 adults, with or without HIV, will gradually increase their walking over six month…

This study looked at over 16,600 people in Spain who had risk factors like high blood pressure or smoking, but no known heart disease. Researchers used ultrasound and urine tests to find hidden signs of artery and kidney disease. The goal is to learn what factors predict these hi…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study looks at how different types of dairy fat affect inflammation in people with metabolic syndrome or obesity. Participants eat a high-fat meal and have their blood tested over six hours. The goal is to understand how dairy fat components influence the body's inflammatory…

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, affects inflammation in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand whether dairy f…

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…

This study looks at whether eating frozen raspberries every day can positively change gut bacteria and improve markers of metabolic syndrome (like blood sugar and cholesterol) in overweight or obese adults. About 59 healthy but overweight men and women will either eat raspberries…