END STAGE RENAL DISEASE

This study tests a blood filtering procedure called rheopheresis to treat calciphylaxis, a rare condition causing painful skin wounds in people on dialysis. About 138 participants will receive either rheopheresis or a sham procedure to see if it helps wounds heal completely withi…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 participants will be randomly assigned to take warfarin or not, and resea…

This study is testing a device called the WavelinQ EndoAVF System, which creates a connection between an artery and a vein (AV fistula) in people with end-stage kidney disease who need dialysis. The goal is to see if this device helps patients start dialysis successfully and keep…

This phase 2 study tests a drug called nedosiran (DCR-PHXC) in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney impairment, with or without dialysis. The goal is to see if the drug safely lowers plasma oxalate levels, which can cause kidney stones and dama…

This study tests whether a stomach acid drug called vonoprazan fumarate can help transplanted kidneys start working sooner. About 47 adults receiving their first kidney from a deceased donor will take the drug daily for a week after surgery. The goal is to see if it reduces the n…

This study tests three different approaches given during donor anesthesia to help the new kidney work better right after transplant. The goal is to see which method—mannitol, dopamine, or extra fluids—best improves kidney function. The study involves 60 adults with end-stage kidn…

This study tests whether injecting Berinert (a C1 esterase inhibitor) into a deceased donor kidney just before transplant can help it work better for the recipient. About 180 adults on dialysis awaiting a kidney transplant will be randomly assigned to receive either Berinert or a…

This study tests whether adding sodium thiosulfate (STS) to the fluid that keeps donated kidneys cold during transport can help them work sooner after transplant. About 120 adults with kidney failure who receive a kidney from a deceased donor will take part. Half of the kidneys w…

This study tests a device that helps people on dialysis get needles into their fistula more easily. It is for patients whose fistula is too deep for standard needle sticks. The study will check if the device works well and is safe over 6 to 12 months. About 100 adults will take p…

This study tests a new way to preserve donated kidneys from older donors (age 50+). Before transplant, some kidneys will be warmed and pumped with a special solution for 6 hours, while others get standard cold storage. The goal is to see if this "warm-up" leads to better kidney f…

This study tests whether adding terlipressin to standard blood pressure medication during kidney transplant surgery helps maintain stable blood pressure and improves kidney function afterward. About 150 adults with end-stage kidney disease will take part. The goal is to see if th…

This study tests whether empagliflozin, a diabetes medicine, is safe and helps control body fluid levels in 60 adults who are starting hemodialysis for end-stage kidney disease. Participants will take either empagliflozin or a placebo for 12 weeks. The goal is to see if the drug …

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers…

This study looks at whether switching from standard anticalcineurin drugs to belatacept improves blood vessel function in kidney transplant patients. Anticalcineurins can harm blood vessels and raise heart risks, while belatacept may be gentler. Researchers will measure vessel di…

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study tests a device that uses automated ultrasound to check how well a dialysis fistula (a surgically created blood vessel connection) is maturing in people with end-stage kidney disease and diabetes. About 304 participants will be randomly assigned to get biweekly automate…

This study follows 150 people who received imlifidase before a kidney transplant to see how long their new kidney works. Researchers will check for graft failure (return to dialysis, re-transplant, or kidney removal) over 5 years. A separate group of similar patients not receivin…

This study compares a once-daily anti-rejection drug (Envarsus XR) to the standard twice-daily drug in 78 adults receiving a kidney transplant. The goal is to see if the once-daily option reduces hidden rejection and improves immune system markers. Participants will be followed f…

This study tests whether kidney transplants from HIV-positive donors are safe and effective for people with HIV and end-stage kidney disease. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track survival and kidney func…

This study tests whether a personalized sodium (salt) management feature on dialysis machines can help people with end-stage kidney disease. It compares the new approach to standard dialysis in 130 adults. The goal is to see if it reduces weight gain between sessions, improves fl…

This study tests a device called VasQ that is placed around a blood vessel connection (fistula) used for dialysis in people with kidney failure. The goal is to see if VasQ helps the fistula work well enough for dialysis sooner and for longer compared to standard fistula creation.…

This study tests a new dialysis solution called XyloCore, which uses less glucose than standard fluids, in 170 adults with end-stage kidney disease on peritoneal dialysis. The goal is to see if it cleans the blood just as well while possibly improving sugar and fat levels. Partic…

This study looks at whether adding CoQ10 (a supplement that supports cell energy) to high-intensity interval training can help people with end-stage kidney disease build muscle and improve physical function. 156 adults on dialysis will be assigned to exercise alone or exercise pl…

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This study tests whether a special app and home monitoring device can help people with advanced chronic kidney disease (stage 5) avoid emergency room visits and hospital stays. About 340 adults will either get usual care or use the VIEWER platform to track their weight and blood …

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease who need regular hemodialysis. The goal is to see if it is safe and works well at cleaning the blood. About 46 adults who are either new to dialysis or already on it will t…

This study looks at whether a special ultrasound inside the vein (IVUS) can find blockages better than the usual X-ray method in people on dialysis. About 50 adults with kidney failure who have trouble with their dialysis access will take part. The goal is to see if IVUS gives cl…

This study tests whether having dialysis patients regularly report their symptoms electronically, and automatically alerting their care teams to severe symptoms, can improve their quality of life. Over 2,200 adults on dialysis in France will take part. The goal is to see if this …

This study tests whether a special dialyzer called Theranova can improve symptoms like pain, sleep, energy, and itching in people with end-stage kidney disease on dialysis. About 100 adults will use the new filter for 24 weeks and report how they feel using a phone app. The goal …

This study looks at whether a 6-week aerobic exercise program can lower uric acid levels and improve daily function and quality of life in people on hemodialysis. Thirty-two patients aged 40 to 60 will be randomly assigned to either exercise or standard care. The goal is to find …

This study tests whether a drug called icatibant can prevent sudden drops in blood pressure during dialysis, a common and serious problem. About 26 adults with kidney failure who often experience these drops will receive either the drug or a placebo in random order. The goal is t…

This study tests whether magnetic stimulation can reduce low back pain and help maintain muscle mass in people with end-stage kidney disease who are on dialysis. About 18 adults with moderate to severe back pain will receive the treatment. Researchers will measure pain levels, ph…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 patients. …

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and cope better with stress. About 60 adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in…

This study tests a 13-week program that teaches mental health skills to people who have recently started or will soon start hemodialysis (a treatment for kidney failure). The program, called dialectical behavioural therapy (DBT) skills training, is designed to help reduce anxiety…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again and improve their quality of life. It includes 43 adults who are either inactive on the waitlist or active but low-income. The program addresses barriers like…

This study tests whether bright light therapy can help reduce fatigue in people with end stage kidney disease who are on hemodialysis. About 60 adults will wear special glasses that give off bright light for one hour during their dialysis sessions, for four weeks. The goal is to …

This study looks at whether measuring kidney-specific DNA in the blood can help monitor kidney transplant health. Researchers will measure these DNA levels in 30 patients before and after transplant surgery. The goal is to tell the difference between DNA from the patient's own fa…

This study looks at whether the sounds made by an arteriovenous fistula (AVF) — a surgically created blood vessel connection used for dialysis — can tell doctors about blood flow conditions. Researchers will use MRI and ultrasound to measure blood flow and compare it to fistula s…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study looks at whether the body can store sodium without holding onto extra water, and how much sodium is stored this way. Researchers will study 10 adults on peritoneal dialysis who also have heart failure. The goal is to better understand sodium balance, which could help i…

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will examine blood and kidney tissue samples taken before and after the transplant to find the cause. The g…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study tests whether a simple neck ultrasound can accurately measure fluid status in people receiving chronic haemodialysis. Researchers will compare ultrasound results with standard methods in 100 participants. The goal is to find a safer, non-invasive way to guide fluid rem…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study looks at how the body controls sodium levels in people with end-stage kidney disease who are on dialysis. Researchers will give patients either extra water or salt water to see how their cells respond. The goal is to better understand sodium balance, which could help i…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…