DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study tests whether measuring drug levels in the blood can help doctors give the right dose of common antidepressants (sertraline or escitalopram) to hospitalized children and adults with major depression. About 180 participants will receive personalized dosing based on thes…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Participants will have at least one risk factor for dementia, such as high blood pressure or memory concerns. The goa…

This study tests a program called I-CONNECT for adults 65 and older who have depression or bipolar disorder plus at least two chronic physical conditions like diabetes or high blood pressure. The program assigns a care coordinator who works with the patient's doctor, psychiatrist…

This study combines smartphone tracking (digital phenotyping) with AI-guided cognitive-behavioral therapy to create a personalized treatment platform for major depression. Researchers will enroll 100 adults aged 18-75 with moderate to severe depression to see if this approach imp…

This study tests whether psilocybin is safe for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spasms, and blood pressure changes over 13 months. The goal i…

This study tests whether adding virtual reality (VR) mindfulness sessions to standard treatment can reduce depression symptoms in people whose depression hasn't improved with multiple medications. 30 adults with treatment-resistant depression will either receive VR mindfulness pl…

This study looks at whether PROSE treatment, a type of contact lens for people with severe dry eye or other eye surface diseases, can also improve mental health. Researchers will track depression symptoms in 200 adults using a standard questionnaire. The goal is to see if treatin…

This study is testing a new way to treat depression using gentle ultrasound waves aimed at specific brain areas. 30 adults with hard-to-treat depression will get personalized, non-invasive brain stimulation while researchers monitor mood and brain activity with MRI. The goal is t…

This pilot study looks at whether a telehealth program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 participants will use an online platform and have health check-ins. The goal is to see if this approach is practical and helpful for …

This study tests two forms of dexamphetamine (a stimulant) against a placebo in 105 adults who have both ADHD and moderate to severe depression. The goal is to see if the drug is safe and can improve symptoms of both conditions. Participants will take tablets or capsules for a se…

This study tests whether heated yoga or sauna sessions, combined with a mindfulness app, can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have at least moderate depression. Participants will be assigned to one of the two heat-based acti…

This study tests whether using a virtual reality headset can make behavioral activation therapy more effective for older adults (65+) with major depression. Thirty participants will try VR-enhanced therapy over several sessions. The goal is to see if this approach is practical, w…

This study tests whether giving multiple brain stimulation sessions per day (accelerated) works better than one session per day (conventional) for treating depression in people aged 60 and older. All 280 participants will receive active treatment, but some get the faster schedule…

This study tests whether a new drug, CYB003, can safely and effectively reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 330 participants will receive either one of two doses of CYB003 or a placebo, added to their current antidepressan…

This study tests an online group therapy program (cognitive behavioral therapy) for people with cystic fibrosis and their caregivers. The goal is to see if it helps reduce symptoms of depression, anxiety, and other mental health challenges. About 52 participants will be randomly …

This study looks at whether adding a type of talk therapy called Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for people who have both alcohol use disorder and depression that hasn't improved with standard medications. The study will enroll 30 partic…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can improve the ability to feel pleasure (anhedonia) in people with major depression. 85 participants, including healthy volunteers, will take psilocybin in two sessions—once with a drug that blocks th…

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app helps reduce depressive feelings and cannabis use, and if p…

This study tests a free, online single-session therapy for teens aged 12-17 in Hong Kong who are waiting for mental health care. The goal is to quickly reduce symptoms of depression and anxiety, and help teens feel more ready for future in-person therapy. About 124 participants w…

This study tests a non-invasive brain stimulation technique called rTMS, guided by MRI, to treat depression in 45 teenagers aged 12-18. The goal is to see if it's safe, acceptable, and helps reduce depressive symptoms. Results will help design larger future studies.

This study tests whether a 4-week digital program that sends activity prompts can increase physical activity and reduce depression, anxiety, and stress in adults with moderate depressive symptoms. About 50 participants will be randomly assigned to receive the program or just have…

This study tests a new psychological therapy designed for adults whose depression stems from difficult childhood experiences. The therapy aims to improve mood, emotional control, and distressing thoughts. Researchers will also take blood samples to see if the therapy causes biolo…

This study tests whether a three-week program combining a daily supplement (sodium butyrate) with virtual reality-based cognitive training can improve memory, attention, and other thinking skills in 160 middle-aged and older adults who have had depression or bipolar disorder but …

This early-stage trial tests a generative AI chatbot called Therabot-CALM to see if it is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen adults will use the app for 4 weeks and give feedback through interviews and surveys.…

This study tests three ways to treat moderate depression in adults aged 18 to 65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step medication plan from a doctor. The goal is to see which approach works best. Participants will be followed …

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study compares two types of brain stimulation for depression: right-sided 1-Hz rTMS and left-sided iTBS. The goal is to see if the right-sided method works as well as the left-sided one. About 350 adults with unipolar or bipolar depression will receive one of the two treatme…

This study looks at whether a Mediterranean diet and time-restricted eating can help college students with mild to moderate depression. Thirty students will track their food, sleep, and mood, and receive diet counseling. The goal is to see if these diet changes are practical and …

This study tests a meditation-based brain-training method to help people with moderate depression. 27 adults will learn to control their brain activity using real-time feedback while meditating. The goal is to see if this approach can reduce depression symptoms without medication…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from a healthy donor — can help adults with major depression who don't respond quickly to antidepressants. About 214 participants will receive either FMT or a placebo, and researchers will…

This study tests whether an artificial intelligence (AI)-guided therapy program can help adults with mild depression or anxiety. Participants will either receive the AI-guided therapy or standard care over 10 weeks. The goal is to see if the AI approach reduces symptoms and impro…

This study tests a brief group therapy program (ACT-i) for adults with chronic insomnia who also have mild depression or anxiety. About 76 people will be randomly assigned to either the therapy or a control group. Researchers will check sleep quality, mood, and thinking before tr…

This study tests a new online, self-guided course based on dialectical behavior therapy (DBT) for adults with mild-to-moderate depression or anxiety. Up to 40 participants in Ontario will use the 8-week program and complete surveys to see if it is easy to use and helpful. The goa…

This study tests whether the medication pramipexole can improve symptoms of depression by acting on specific brain circuits. Researchers will use brain scans to see if people with different circuit patterns respond differently. About 60 adults with recent depression symptoms will…

This study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.

This study is testing a new blood test to see if it can help doctors tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will collect blood samples and mental health surveys from 500 adults over three visits. Th…

This study aims to identify subgroups of people with diabetes who share similar patterns in how their blood sugar and mental health (like distress, anxiety, or eating disorders) are linked. Over 1,800 participants will use smartphone surveys and continuous glucose monitors for tw…

This study looks at how the antidepressant fluoxetine changes the way healthy young people (ages 18-24) process anger. Participants take either fluoxetine or a placebo daily for 7 days and complete tasks involving angry faces, words, and frustrating situations. The goal is to und…

This study looks at how memory, attention, and other thinking skills relate to work performance and sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. The goal is to understand if i…

This study uses brain imaging (fMRI) to explore why people with schizophrenia or depression often struggle with memory and managing emotions. Researchers will compare brain activity in 90 adults who have one of these conditions. The goal is to better understand the brain mechanis…

This observational study in Seoul, Korea, follows 180 adults aged 60 and older to see how everyday emotional stress impacts memory and thinking. Participants use a smartphone app and a smartwatch for two weeks, then return for check-ups at 6 months and 1 year. The goal is to find…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. About 67 adults with depression will receive different doses of stimulation or a sham (fake) treatment to see which do…

This study is watching how the drug trazodone works in everyday medical practice for people aged 55 and older who have both major depression and mild cognitive impairment (slight memory or thinking problems). Researchers will track changes in depression symptoms using a standard …

This study looks at how the brain works during tasks involving emotions, attention, and memory in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to measure activity. The goal is to gather information that could lead to…