DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study aims to find the best way to treat moderate depression in a general doctor's office. It will compare three approaches: standard care from a doctor, standard therapy from a psychologist, and a structured, step-by-step medication plan managed by a doctor. The goal is to …

This study aims to find the best way to dose three common antidepressants (fluoxetine, sertraline, and escitalopram) for teenagers and adults with depression. Researchers will use blood tests to monitor drug levels and adjust doses for each person, hoping to improve effectiveness…

This study is testing a new drug called CYB003 to see if it helps reduce symptoms of major depression when added to a person's current antidepressant medication. It will involve 330 adults with moderate to severe depression who are already on a stable dose of antidepressants. Par…

This study is testing whether adding a specific type of talk therapy (Acceptance and Commitment Therapy) to ketamine treatment is a practical and helpful approach for people struggling with both alcohol use disorder and depression that hasn't responded to other treatments. It wil…

This study is testing whether a stimulant medication, dexamfetamine, can help adults who have both ADHD and moderate to severe depression. Researchers will compare two different pill formulations (one long-acting, one short-acting) against a placebo (sugar pill) in 105 participan…

This study is testing a new coordinated care program called I-CONNECT for older adults who have depression or bipolar disorder along with at least two chronic physical conditions like diabetes or high blood pressure. Researchers want to see if this program, which provides a perso…

This study is testing whether a three-week virtual reality brain training program, combined with a daily pill (sodium butyrate), can improve thinking skills like memory and focus in middle-aged and older adults who have had depression or bipolar disorder but are currently stable.…

This study is testing a new digital health platform that combines AI-guided therapy with data from a smartwatch to create personalized treatment plans for adults with moderate to severe depression. It aims to see if tracking daily activity, sleep, and stress through a wearable de…

This study is testing a smartphone app designed to help people who are dealing with both depression and frequent cannabis use. The app focuses on increasing positive feelings and motivation. Researchers will compare the app to simple symptom tracking to see if it helps reduce dep…

This study tests whether giving multiple brain stimulation treatments per day works better than one daily treatment for depression in people aged 60+. All participants receive active treatment, but some get multiple sessions daily for a shorter period while others get one session…

This study aims to observe how well the antidepressant trazodone works for older adults who have both moderate-to-severe depression and mild memory problems. Researchers will follow 120 patients in Italy, Poland, and Romania as they receive this medication as part of their standa…

This study aims to find out if a newer, faster form of non-invasive brain stimulation works as well as a standard method for treating depression. It will involve 350 adults in Sweden with depression. Researchers will compare how much each treatment reduces depression symptoms and…

This study is testing a new, non-invasive brain stimulation method using focused ultrasound for people with treatment-resistant depression. Researchers will use MRI scans to personalize the treatment target and monitor brain activity during stimulation. The trial aims to see if t…

This study is testing a new 12-week virtual talk therapy designed for adults whose depression is linked to difficult childhood experiences. Researchers want to see if this therapy helps improve mood and emotional control. They are also checking blood samples to understand how str…

This study is testing whether a simple daily breathing exercise can help reduce dementia risk in older adults. Researchers will compare a high-resistance breathing training to a low-resistance version over 8 weeks. They'll measure effects on blood pressure, thinking skills, mood,…

This study is testing whether a fecal microbiota transplant (FMT) can help people with major depression who don't get better enough after starting a standard antidepressant. About 214 participants will take either FMT capsules or placebo pills for four weeks while continuing thei…

This study is testing whether a new blood test can help doctors better diagnose depression and schizophrenia. Researchers will follow 500 participants with these conditions to see if the blood test can distinguish between different diagnoses and predict who will respond to treatm…

This study is testing whether a simple smartphone app can help people feel less depressed by encouraging them to be more active. For four weeks, some participants will get daily phone notifications suggesting they do physical activities they enjoy, while others will not. Research…

This study is testing a single, one-hour online therapy session for children and teenagers in Hong Kong who are stuck on long waitlists for in-person mental health treatment. The goal is to see if this brief, free session can help reduce symptoms of depression and anxiety while t…

This study is testing whether adding a virtual reality (VR) mindfulness program to standard medication helps people with treatment-resistant depression. Thirty participants will be randomly assigned to receive either their usual medication alone or medication plus eight VR mindfu…

This study is testing whether a telehealth mental health program is practical and helpful for family members of people who survived a serious illness in the intensive care unit (ICU). About 150 family members will be randomly assigned to either use a special online support platfo…

This study is testing whether a digital mental health support program can help people recovering from a serious ICU stay. 150 patients will be randomly assigned to either use a special app with coaching and psychiatric support for 6 months, or receive standard follow-up care. Res…

This study is testing whether using a virtual reality (VR) headset can make a standard depression therapy more helpful for adults aged 65 and older. Participants will work with a therapist to plan enjoyable activities and try some of them in VR, rating their mood before and after…

This study is testing whether a 10-session program combining meditation with neurofeedback technology can help reduce symptoms of depression. Researchers are enrolling 27 adults with moderate depression to try this non-drug approach. The goal is to see if it improves mood, reduce…

This study is testing whether online group cognitive behavioral therapy can help improve mental health for people with cystic fibrosis and their caregivers. It will compare this specific therapy to general online support groups over 13 weekly sessions. The goal is to see which ap…

This early-stage study is testing whether a new AI chatbot, called Therabot-CALM, is easy to use and acceptable for people who have cannabis use disorder along with anxiety or depression. The main goal is to see if people find the app helpful and user-friendly, not to prove it tr…

This pilot study is testing whether a non-invasive brain stimulation therapy, guided by MRI scans, can help reduce depression symptoms in teenagers. Researchers will compare a new, personalized stimulation target to a standard target and a placebo treatment in 45 adolescents with…

This study is testing whether dietary changes are a practical way to help college students with mild to moderate depression. Researchers will see if students can stick to a Mediterranean diet, or that diet combined with eating only within a 10-hour window each day. The main goal …

This study aims to find out if heated yoga, regular sauna use, or a mindfulness app can help reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression and assign them to one of these three activities for 12 weeks. They will measure changes in depr…

This study is testing if a special, custom-made contact lens (called PROSE) can improve mental health in people with severe dry eye disease. The lens is designed to protect the eye, reduce pain, and improve vision. Researchers want to see if relieving these difficult eye symptoms…

This early-stage study from Yale University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people whose daily lives are impacted by symptoms of depression, anxiety, trauma, or addiction. The study will enroll 50…

This study aims to understand why people with schizophrenia or depression have trouble with memory and managing emotions. Researchers will use brain scans (fMRI) on 90 participants to see how the brain works during thinking tasks. The goal is to learn more about the brain mechani…

This University of Oxford study aims to understand how the antidepressant fluoxetine (Prozac) affects how healthy young people process anger. 80 participants aged 18-24 will take either a 20mg fluoxetine pill or a placebo daily for one week and complete tasks designed to measure …

This study aims to understand how problems with memory, focus, and thinking (cognitive functioning) are related to taking sick leave from work for people with depression and anxiety. Researchers will follow 200 people at risk of sick leave who are receiving a specific therapy (me…

This study aims to understand how the brain processes emotions and thoughts in both healthy people and those with depression. Researchers will use brain scans and gentle magnetic stimulation while participants do computer tasks. The goal is to gather information that could lead t…

This study aims to better understand the link between mental health and blood sugar control in people with diabetes. Researchers will follow about 1,800 participants for several years, collecting data on their mood, stress, and glucose levels to create 'digital twin' computer mod…