DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This study tests a personalized program combining lifestyle changes (exercise, diet, sleep, social activities), a weight-loss medication (semaglutide) for those who are overweight, and optional brain stimulation for depression. The goal is to improve mental functioning in 140 adu…

This study is testing a smartphone app that analyzes your voice to screen for depression and anxiety. Researchers will ask 80 university students to complete speaking tasks and compare the app's results with standard questionnaires. The goal is to see if speech patterns can help …

This study will see if an artificial intelligence (AI) tool can analyze speech recordings to help identify people with memory problems who need specialist dementia care. Researchers will record 440 Danish-speaking adults over 50 as they perform cognitive tests and speaking tasks.…

This study tests a two-session, Zoom-based cognitive behavioral therapy program designed for Deaf adults who use American Sign Language. The goal is to change negative beliefs about mental health treatment and encourage participants to seek professional help. Researchers will als…

This study looks at how well the antidepressant escitalopram works in 200 adults who are having their first episode of major depression and have never taken medication for it. Participants will take escitalopram for 8 weeks, and researchers will track their symptoms, thinking ski…

This pilot study tests whether a headband that plays soft sounds in sync with brain waves can improve sleep for 25 adults with both depression and insomnia. Participants wear the device at home for four weeks, alternating between active and sham stimulation, while tracking sleep …

This study tests whether using a person's genetic test results to guide medication decisions, delivered by community pharmacists, can improve depression symptoms. About 220 adults with mild or worse depression who need to start or change an antidepressant will be randomly assigne…

This study tests a type of brain stimulation called theta burst stimulation (TBS) in 120 people with depression that hasn't improved with medication. Participants will receive either real or fake stimulation first, then everyone gets the real treatment. The goal is to see if TBS …

This study tests whether a self-guided mobile app for cognitive behavioral therapy for insomnia (CBTI) can improve sleep and related issues like depression and PTSD in 144 active-duty service members. Participants use the app for five weeks, and researchers measure changes in sle…

This study tests whether using a person's genetic information can help doctors choose the most effective antidepressant for major depression. About 570 adults in Morocco will be randomly assigned to either standard care or care guided by a genetic test. The goal is to see if gene…

This study tests whether a mental health app can reduce depression and improve resilience in medical students. About 220 students will be split into two groups: one gets full access to the app, the other gets basic access. Researchers will measure changes in mood, anxiety, and se…

This study tests whether a rapid form of brain stimulation called accelerated iTBS can reduce depression symptoms in adults. Over 5 days, participants receive 50 sessions of either real or sham (placebo) stimulation. Researchers also use brain scans, blood tests, and a mobile app…

This study tests a non-invasive brain stimulation method called tACS in 30 teens aged 12-18 who have first-episode depression and have never taken antidepressants. The goal is to see if tACS can safely reduce depression symptoms and improve emotional and thinking skills. Particip…

This study looks at whether selenium supplements can reduce depression symptoms in children and teenagers aged 12 to 18 who have major depressive disorder. Researchers will measure changes in depression scores over time. The goal is to find a new, simple way to help young people …

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help reduce depression symptoms in adolescents aged 12-18 who are already on stable medication. The treatment involves wearing a cap that delivers a mild electrical current to the brain duri…

This study tests whether an 8-week psychoeducation program, based on Acceptance and Commitment Therapy, can help people with depression feel more meaning in life and improve their self-care. About 46 adults receiving TMS treatment for depression will be randomly assigned to eithe…

This study compares two strategies for safely stopping antidepressants in adults whose depression is in remission. Participants will be randomly assigned to either a standard gradual dose reduction or a more precise hyperbolic tapering method. The goal is to see which approach he…

This small pilot study tests whether a non-invasive device that gently stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep leads to improvements in memory, thinking, and mood. Twelve participants will w…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with mindfulness-based therapy can help ease symptoms of posttraumatic stress disorder (PTSD). Thirty adults with PTSD will receive psilocybin along with either standard suppo…

This early-stage study tests whether a non-invasive brain stimulation technique called rTMS is safe and can help ease depression and fatigue in adults with multiple sclerosis (MS). About 20 participants with MS and moderate-to-severe depression will receive daily rTMS sessions fo…

This study tests whether combining psilocybin (the active ingredient in magic mushrooms) with the antidepressant trazodone can improve depression symptoms without causing intense psychedelic experiences. About 112 adults with treatment-resistant depression will receive either psi…

This study will test whether psilocybin (the active ingredient in magic mushrooms) combined with cognitive behavioral therapy in a group setting is acceptable and feasible for people with major depression. Thirty adults aged 21-60 with current depressive symptoms will participate…

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with grief after losing a loved one. Participants will be split into three groups: one using AI-guided writing, one using writing without feedback, and one doing fre…

This study will test whether an 8-week mindfulness-based psychoeducation program can reduce depression symptoms, improve stress tolerance, and help with emotion regulation in adults diagnosed with major depression. About 70 outpatients in Gaziantep, Turkey, who have been treated …

This study tests a fast-acting brain stimulation method called a-iTBS in 45 teens aged 12-18 with major depression. The goal is to see if it is safe, acceptable, and helps reduce depressive symptoms. Participants will receive either real or fake stimulation to compare effects.

This study tests a computer-based training program called action-based cognitive remediation (ABCR) to see if it can improve thinking, social, and work skills in people with various psychiatric conditions like depression, schizophrenia, and PTSD. 160 participants will first wait …

This study tests a non-invasive device that uses gentle electrical currents to the brain to reduce symptoms of major depression. It involves 214 adults who have not gotten enough relief from antidepressants. The goal is to see if this closed-loop stimulation can safely improve mo…

This study aims to find out if very short psychological treatments can effectively reduce symptoms of anxiety, depression, and stress-related physical symptoms. Researchers will compare four different approaches: group therapy lasting eight sessions, group therapy lasting four se…

This study aims to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with major depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The study will involve 64 adults …

This study looks at whether watching a short educational video can reduce the stigma teenagers feel about depression. Researchers will recruit 500 teens aged 8-18, some with depression and some without. Teens will watch either a video about depression stigma or a neutral video ab…

This study aims to find out how common depression is among medical students at Sohag University. About 300 students aged 18 to 25 will be surveyed. The goal is to better understand the mental health challenges faced by medical students, who are under high stress from academics an…

This study looks at whether a tailored exercise program can help muscle cells recover oxygen faster after activity in menopausal women with major depression. Researchers will measure muscle oxygen levels using a light-based device before and after an 8-week program. The goal is t…

This study looks at how two different types of noninvasive brain stimulation change brain activity and the body's stress response in people with both PTSD and major depression. Fifty adults will receive both active and sham (fake) stimulation in a random order, with brain and hea…

This study looks at whether special cells in the eye can help predict who will respond to a brain stimulation treatment called TMS for severe depression. Researchers will measure eye responses in 44 people before and after TMS, and check if those measurements match improvements i…

This study looks at how natural hormone changes during the menstrual cycle impact brain areas linked to mood and irritability in teenage girls at risk of suicide. Fifty girls aged 12-16 will take either a birth control pill to stabilize hormones or a placebo for 8 weeks each, whi…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will compare drug levels in premenopausal and postmenopausal women aged 40-60 who take the medication for depression or anxiety. The goal is to help doctors per…

This study looks back at data from 80 veterans and first responders who completed a 12-week wellness program that combined therapy, exercise, and nutrition. Researchers will use wearable rings to track sleep and activity, along with surveys and interviews, to see how the program …

This study looks at ways to make talk therapy work better for people with major depression. Researchers will compare once-weekly versus twice-weekly sessions of two common therapies (CBT and psychodynamic therapy) to see if more frequent visits lead to faster and longer-lasting r…

This study uses brain scans to understand why some young people (ages 14-24) have suicidal thoughts or attempt suicide. Researchers will compare brain activity in three groups: those who recently attempted suicide, those with ongoing suicidal thoughts, and healthy controls. High-…

This study will enroll 2000 adults with major depressive disorder or bipolar depression to understand why some people respond to treatment and others do not. Researchers will analyze clinical symptoms, genetics, metabolism, and immune markers. Participants may also be contacted f…

This study looks at how medication, talk therapy, or both together change the way depression symptoms connect and influence each other over time. Researchers will track 90 adults with mild to moderate depression using smartphone surveys to see which treatment leads to better symp…