DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study is testing whether a gentle, non-invasive brain stimulation treatment can help teenagers with depression feel better faster when added to their regular medication. Thirty teens aged 12-18 who are already on stable depression medication will receive either real or fake …

This small pilot study is testing whether a non-invasive brain stimulation device, called transcranial alternating current stimulation (tACS), can help teenagers experiencing their first episode of depression. Thirty participants, aged 12-18 who have never taken antidepressants, …

This study is testing whether a faster, 5-day version of a non-invasive brain stimulation treatment can help reduce symptoms of depression. 264 adults with depression will be randomly assigned to receive either the real treatment or a placebo version. Researchers will measure cha…

This study is testing two different types of non-invasive brain stimulation to see how they affect brain activity and the body's stress response in people who have both post-traumatic stress disorder (PTSD) and major depression. Researchers will measure changes in brain blood flo…

This study aims to understand how a single dose of psilocybin (the active compound in 'magic mushrooms'), given with different types of therapy, might help people with PTSD. It will enroll 30 adults with moderate to severe PTSD to see how their brain activity and symptoms change.…

This study aims to see if adding a selenium supplement to standard depression medication (fluoxetine) helps reduce depression symptoms in teenagers aged 12-18. It will involve 172 participants who will be randomly assigned to receive either the supplement or a placebo (inactive p…

This study is testing a new approach for people with depression that hasn't improved with standard treatments. Researchers want to see if psilocybin, a compound from 'magic mushrooms,' can relieve depression even when its psychedelic effects are blocked by another drug called tra…

This study is testing whether using a person's genetic test results to guide antidepressant prescriptions leads to better depression control. About 220 adults starting or adjusting their antidepressant medication will be randomly assigned to either receive this personalized, phar…

This study aims to see if using a genetic test to guide antidepressant choice works better than standard care for adults with major depression in Morocco. About 570 participants will be randomly assigned to have their treatment chosen either with the help of their genetic test re…

This is a small, early-stage study to test a faster version of a non-invasive brain stimulation treatment for teenagers with depression. Over 10 days, 45 participants will receive either real or sham stimulation to see if the real treatment is safe, acceptable, and shows signs of…

This study is testing whether a non-invasive brain stimulation device worn on the head can reduce symptoms of major depression. It will involve about 214 adults with moderate to severe depression who haven't gotten enough relief from at least one antidepressant medication. Partic…

This study aims to find the best way for people to safely stop taking antidepressant medication when their depression is under control. It will compare two different tapering (gradual dose reduction) methods in 150 adults in Italy who have been stable on antidepressants for at le…

This study is testing a new support package for older adults who have two or more long-term health problems, like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support to help manage their health. Researchers w…

This study is testing whether a computer-based skills training program can help improve thinking, social, and work abilities in people with various mental health conditions like depression, anxiety, or schizophrenia. Participants will first wait 8 weeks, then complete an 8-week p…

This study aims to improve therapy for people with depression. It will test if having therapy sessions twice a week, instead of once a week, leads to faster and better relief from depressive symptoms. Researchers will also study which type of therapy works best for different peop…

This study aims to see if an 8-week mindfulness-based education program can help adults diagnosed with depression. It will measure if the program reduces symptom severity, improves stress tolerance, and helps with emotion regulation. The research will involve 70 participants in G…

This study aims to see if psilocybin, the active compound in 'magic mushrooms,' is safe and can help reduce depression symptoms in veterans with spinal cord injuries. Researchers will test three different doses (low, medium, and high) in 30 participants over about 13 months. The …

This small pilot study is testing whether a gentle, non-invasive electrical stimulation delivered to the scalp during deep sleep can improve that deep sleep in adults with depression. Researchers want to see if boosting deep sleep leads to better memory, thinking speed, and mood.…

This study is testing whether adding a traditional Chinese herbal formula, called Compound Ciwujia Granules, to standard antidepressant medication (SSRIs) can help reduce symptoms of depression more effectively. It will involve 60 adults with a specific pattern of depression desc…

This study is testing a brief, two-session online therapy program designed specifically for Deaf adults. The goal is to see if this therapy can help change negative beliefs about mental health treatment and encourage more people to seek professional help. Researchers will also ch…

This study tests whether very short psychological treatments can help reduce symptoms of anxiety, depression, and physical symptoms related to stress. Researchers will compare four or eight sessions of group or individual therapy against a relaxation control group. The goal is to…

This pilot study is testing whether a self-guided smartphone app can help service members with insomnia sleep better. 144 active-duty military personnel will be randomly assigned to either use the app for five weeks or wait. Researchers will measure changes in sleep quality, dayt…

This study aims to see if using a mental health app for three months can help medical students feel less depressed and more resilient to stress. Researchers will compare 220 students who get full access to the app against a group with limited access. The goal is to find new ways …

This study is testing whether a tailored exercise program can improve how the body's cells produce energy and reduce depression symptoms in menopausal women. It will compare the exercise program to a non-exercise therapy in 52 women receiving psychiatric care. The main goal is to…

This study is testing whether adding a special 8-week talk therapy program to standard brain stimulation treatment helps people with depression. The program teaches skills for finding more meaning in life and improving daily self-care. Researchers will compare two groups: one get…

This study aims to see if watching educational videos can reduce the stigma surrounding depression and encourage teens to seek help. It will involve 500 adolescents in China, aged 8 to 18, who will watch different videos based on whether they have symptoms of depression or not. T…

This study is looking at past data to understand how a 12-week wellness program helps veterans and first responders. The program combines therapy, nutrition, and fitness support. Researchers will analyze health surveys and data from wearable rings to see if the program improved m…

This study aims to find out why some people with depression get better with treatment while others do not. Researchers will collect detailed information from 2,000 participants, including genetic data, blood tests, and surveys about symptoms and life experiences. The goal is to u…

This study aims to find out if special light-sensitive cells in the back of the eye can help predict which patients with hard-to-treat depression will respond well to a non-invasive brain stimulation therapy. Researchers will give 44 participants with treatment-resistant depressi…

This study aims to understand if menopause changes how a woman's body processes the common antidepressant escitalopram. Researchers will observe 94 women aged 40-60, comparing those before and after menopause. The goal is to gather information that could help doctors personalize …

This study aims to measure how common depression is among medical students at Sohag University. It will survey 300 students aged 18 to 25 to understand the scale of this mental health challenge. The goal is to gather information that could help improve support for students in the…